Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion

Topçu, Hasan Onur; İskender, Cantekin; Ceran, Ufuk; Kaymak, Oktay; Tımur, Hakan; Uygur, Dilek; Danışman, Nuri

doi:10.3390/diagnostics5010001

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…There is detailed analysis, which revealed patients with cancer who had elevated D-dimer and elevated F 1 + 2 had the highest risk of developing VTE [37]. The D-dimer levels are not only useful in cancers, but this can also be utilized during pregnancy, where; diagnostic accuracy can be assessed for adnexal torsion (AT) in pregnant women [38]. Sometimes it needs to differentiate between other lesions such as fungal, bacterial and viral infections may also result DIC [39].…”

Section: Discussionmentioning

confidence: 99%

D-dimer as an alarming biomarker in various cancers: a review of literature

Vikey¹

2018

Glob Med Therap

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Today cancer is the major health threat; and lot of efforts are being taken by many researchers; to fight against it. Even after these advancements in technologies, still death rate is gradually increasing, and the reason is late detection, delayed treatments and vascular complications, such as venous thromboembolic events (VTE). To overcome this; there is need of accurate and prompt investigation; which will guide during intervention with its effectiveness and feasibility, recently one of such investigations is to assess levels of D-dimer.The review is compiled through the search of electronic media; mainly Google search, Ebscohost and Pub-med etc. During search relevant key words inserted such as, D-dimer, oral cancer, Fibrinogen, Fibrinogen-degradation product (FDP), Head-neck cancer and VTE etc.Blood plays crucial role in many investigations; and very important in cancers. This is proved that, a degradation component of blood called D-dimer, may play important role during interventions of oral & other cancers.

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Section: Discussionmentioning

confidence: 99%

D-dimer as an alarming biomarker in various cancers: a review of literature

Vikey¹

2018

Glob Med Therap

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“…D‐dimer is a major degradation product of polymerized fibrin after blood coagulation and plasmin processing. Elevated plasma D‐dimer levels usually indicate active fibrinolysis and are observed in several disorders, including arterial and venous thromboembolic disease, disseminated intravascular coagulation, malignancy, and renal and liver disease . Serum D‐dimer has been reported as a useful diagnosis and prognosis parameter for several malignancies including ovarian cancer .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of serum D‐dimer,CA125, and neutrophil‐to‐lymphocyte ratio in differentiating ovarian cancer and endometriosis

Chen

Wang

Shu

et al. 2019

Intl J Gynecology & Obste

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Objective: To assess the utility of hematologic, inflammatory, and immunologic biomarkers for differentiating between ovarian cancer and endometriosis.Methods: Data were retrospectively reviewed from women diagnosed with ovarian cancer and endometriosis after ovarian cyst surgery in Zhejiang, China, 2014 Serologic and hematologic biomarkers, including white blood cell count, lymphocyte count, neutrophil count, red blood cell count, hemoglobin, platelets, and D-dimer, albumin, globulin, cancer antigen 125 (CA125) and CA199 serum levels recorded preoperatively were assessed by ROC curve and logistic regression analysis. Results:Overall, 49 women were diagnosed with ovarian cancer and 192 with endometriosis. For predicting ovarian cancer, the area under the curve (AUC) was 0.96 (95% confidence interval [CI], 0.94-0.99); sensitivity, 93.2%; specificity, 87.5%) for log(Ddimer), 0.95 (95% CI, 0.91-0.98; sensitivity, 81.3%; specificity, 96.3%) for log(CA125), and 0.92 (95% CI, 0.86-0.98; sensitivity, 92.6%; specificity, 79.2%) for neutrophil-tolymphocyte ratio (NLR). The AUC for the combination of D-dimer, NLR, and CA125 was 0.96 (95% CI, 0.94-0.99; sensitivity, 91.6%; specificity, 89.6%).Conclusion: Serum D-dimer, NLR, and CA125 were found to be potential diagnostic factors for ovarian cancer. Combined measurement of D-dimer, NLR, and CA125 might offer a convenient screening method.

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“…A third diagnostic test demonstrated to be valid in the evaluation of a suspected ovarian torsion is the D-dimer quantification. The clinical association between D-dimer values and ovarian torsion has been studied in animal models since 2011 and later retrospective studies have then concluded that this parameter may be used for the early diagnosis of adnexal torsion [6,7].…”

Section: Introductionmentioning

confidence: 99%

Successful Pregnancy Complicated by Adnexal Torsion after IVF in a 45-Year-Old Woman

Cirillo¹,

Zannoni²

2016

Gynecol Obstet Case Rep

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Ovarian torsion accounts for 3% of gynecological emergencies. Its incidence is higher in all those cases of ovarian hypermobility and adnexal masses, such as Ovarian Hyperstimulation Syndrome (OHSS) as a consequence of in vitro fertilization (IVF) treatments. It is an acute condition; its diagnostic work-up is difficult because of its vague clinical presentation. Nonetheless its diagnosis must be as rapid as possible because a prompt surgical detorsion is the only treatment assuring ovarian function recovery. The diagnostic iter includes complete cell blood count, D-dimer, transabdominal ultrasound (US), transvaginal US and magnetic resonance (MRI).Our patient was a 45-year-old woman with good ovarian reserve indexes. She underwent a second level IVF stimulation because of a male infertility factor. Despite her age she developed an OHSS. Furthermore, twenty minutes after the embryo transfer, a right ovarian torsion occurred; the definitive diagnosis was made thanks to TV US and abdominal MRI. The patient was immediately treated with laparoscopic detorsion and after two weeks from the embryo transfer her beta HCG were positive with regular duplication times.The significance of this case stands in the chosen diagnostic iter, which actually underlines the importance of MRI in the prevention of useless surgeries, and in the patient's clinical peculiarity: despite the advanced age she developed an OHSS and, despite the ovarian torsion and the surgery, she successfully got pregnant.

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Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion

Cited by 6 publications

References 22 publications

D-dimer as an alarming biomarker in various cancers: a review of literature

D-dimer as an alarming biomarker in various cancers: a review of literature

Diagnostic value of serum D‐dimer,CA125, and neutrophil‐to‐lymphocyte ratio in differentiating ovarian cancer and endometriosis

Successful Pregnancy Complicated by Adnexal Torsion after IVF in a 45-Year-Old Woman

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