Evaluation of the diagnostic value of plasma copper levels in cattle

Minatel, Leonardo; Carfagnini, J. C.

doi:10.1016/s0167-5877(01)00277-x

Cited by 17 publications

(12 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results were in concern with those reported by Ghanem and Abd-El Raof, (2006). These results could be attributed to Copper is a cofactor of several metalloenzymes and other metalloproteins (such as ceruloplasmin, superoxide dismutase, cytochrome oxidase, lysyl oxidase, and metallothionein) Minatel and Carfagnini (2002). Also these data was in agreement with (Sadiek el al., 1994and Borghese, 2005and Gressley, 2009 who conclude that deficiency of copper results in poor growth, Unthriftiness and coat and skin abnormality .…”

Section: Discussionsupporting

confidence: 88%

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Ismael¹,

El-Sayed²,

Metwally³

et al. 2015

AJVS

View full text Add to dashboard Cite

The goal of the present study was to evaluate some trace element concentrations and the activity of antioxidant systems in ill-thrift calves. A total number of (52) buffalo-calf was subjected to study. Out of them, (37) buffalo-calves had poor coat, poor general body condition score which constituted the ill-thrift group. The remained animals (15) were clinically healthy and kept as control group. Complete blood picture, trace elements profile, serum calcium, phosphorus & magnesium , blood urea nitrogen (BUN) , creatinine, some liver function parameters and total antioxidants capacity were evaluated. Results showed a significant reduction in the blood serum concentration of copper, cobalt, iron, selenium and zinc associated with normocytic normochromic anemia. Also a significant reduction in the activity of total antioxidants value was evident in ill-thrift calves. While levels of serum calcium, phosphorus and magnesium , blood urea nitrogen, creatinine and liver function parameters showed non-significant changes. In conclusion, a state of sub-optimal growth (ill-thrift) in buffalo-calves was largely attributed to trace element deficiency, in particular copper, cobalt, iron, selenium and zinc deficiency that may cause reduction in the total antioxidant capacity, with a lower ability to reduce oxidative compounds.

show abstract

Section: Discussionsupporting

confidence: 88%

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Ismael¹,

El-Sayed²,

Metwally³

et al. 2015

AJVS

View full text Add to dashboard Cite

show abstract

“…In present results, serum trace minerals level was not included in the final logistic regression model, but their implication in univariate analysis may reflect their importance in calf health. Generally, trace minerals are a cofactor of several metalloenzymes and other metalloproteins and antioxidant enzymes [31] . In addition, deficiency of some trace elements not only cause clinical disease, but also affect on absorption of other elements [1] .…”

Section: Discussionmentioning

confidence: 99%

Potential risk factors associated with ill-thrift in buffalo calves (Bubalus bubalis) raised at smallholder farms in Egypt

Ali

El-Khodery

El-said

2015

Journal of Advanced Research

View full text Add to dashboard Cite

Failure to grow (ill-thrift) in calves has a negative effect on animal production and health. The present study was carried out from November, 2009 to May, 2013 to investigate the risk factors of ill-thrift in buffalo calves. A total of 344 calves at 78 smallholder farms were selected randomly. A questionnaire was designed to include managemental, nutritional and disease risk factors. Serum selenium, copper, zinc, iron, calcium, phosphorus and magnesium were measured. Data were subjected to logistic regression analysis and results were expressed as p value, odds ratio (OR) and confidence interval (CI). Fifty-five calves (15.9%) showed ill-thrift. On animal level, the final multivariate logistic regression model showed a significant association between ill-thrift and early weaning (p < 0.01; OR: 45.755; CI: 4.35–480.25), diarrhea (p < 0.05; OR: 41.315; CI: 1.710–998.0), indoor management (p < 0.05; OR: 63.56; CI: 2.701–14.96) and low serum phosphorus (p < 0.01; 292.0; CI: 5.256–16.23). On farm level, inadequate mineral supplementation (p < 0.001; OR: 18.62; CI: 3.89–88.9) and irregular use of anthelmintics (p < 0.05; OR: 7.95; CI: 1.53–41.23) were the potential factors. Clinically, ill-thrift calves were more likely to have alopecia (p < 0.01), recumbency (p < 0.01), emaciation (p < 0.001), hypothermia (p < 0.01), inappetance (p < 0.001), lacrimation (p < 0.001), hypomotile rumen (p < 0.001), and pale mucous membrane (p < 0.001). The results of the present study indicate that ill-thrift in buffalo calves could occur as a result of interaction between management errors and disease factors. Identification of the risk factors associated with ill-thrift may provide useful information, which assist to construct the suitable preventive measures.

show abstract

“…14 Sensitivity, specificity, accuracy, and positive and negative predictive values were calculated to obtain the best discrimination value to determine the relationship between hepatic enzymatic activity and Cu accumulation. 10,15 The correlations between the GGT serum activities and hepatic Cu concentrations observed in cattle and buffalo are illustrated in Figures 1 and 2, respectively. For cattle, a potential regression found that the coefficient of determination (R 2 ) 5 0.5838, while for buffalo, the exponential regression was R 2 5 0.5786.…”

mentioning

confidence: 99%

Predictive Values of Aspartate Aminotransferase and Gamma-Glutamyl Transferase for the Hepatic Accumulation of Copper in Cattle and Buffalo

et al. 2008

View full text Add to dashboard Cite

Abstract. Ten cattle and 10 buffalo were divided into 2 groups (control [n 5 8] and experimental [n 5 12]) that received daily administration of copper. Three hepatic biopsies and blood samples were performed on days 0, 45, and 105. The concentration of hepatic copper was determined by spectrophotometric atomic absorption, and the activities of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) were analyzed. Regression analyses were done to verify the possible existing relationship between enzymatic activity and concentration of hepatic copper. Sensitivity, specificity, accuracy, and positive and negative predictive values were determined. The serum activities of AST and GGT had coefficients of determination that were excellent predictive indicators of hepatic copper accumulation in cattle, while only GGT serum activity was predictive of hepatic copper accumulation in buffalo. Elevated serum GGT activity may be indicative of increased concentrations of hepatic copper even in cattle and buffalo that appear to be clinically healthy. Thus, prophylactic measures can be implemented to prevent the onset of a hemolytic crisis that is characteristic of copper intoxication.

show abstract

Evaluation of the diagnostic value of plasma copper levels in cattle

Cited by 17 publications

References 11 publications

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Trace Elements Status and Antioxidants Profile in Ill-thrift Buffalo Calves

Potential risk factors associated with ill-thrift in buffalo calves (Bubalus bubalis) raised at smallholder farms in Egypt

Predictive Values of Aspartate Aminotransferase and Gamma-Glutamyl Transferase for the Hepatic Accumulation of Copper in Cattle and Buffalo

Contact Info

Product

Resources

About