Evaluation of the diagnostic value of platelet indices in pediatric acute appendicitis

Oktay, Mehmet Murat; Boğan, Mustafa; Çolak, Selcan Türker; Sabak, Mustafa; Gümüşboğa, Hasan; Eren, Şevki Hakan

doi:10.1177/0300060520946515

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…The study discovered that kids with AA had significantly lower MPV values (p <0.001) [26] . The current findings are in line with those of Oktay et al [27] who split 207 pediatric patients into three groups (non-AA, uncomplicated AA, and complicated AA). The non-AA group had the greatest mean MPV, and there was a statistical significance in MPV across the groups (p = 0.047).…”

Section: Discussionsupporting

confidence: 92%

Mean Platelet Volume versus Alvarado Score as Predictor of Acute Appendicitis

2023

The Egyptian Journal of Hospital Medicine

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Background: For assisting in the early identification of acute appendicitis (AA) and its prompt therapy, several grading systems have been utilized. Because it takes into account the patient symptoms, findings, and laboratory assessment, the Alvarado score was chosen. Mean platelet volume (MPV) variations could be a sign of production of platelet in addition, a sign of changes in the severity of a number of disorders.Objective: This study aimed to compare MPV and Alvarado score to assess the predictive value for acute appendicitis. Patients and Methods: At the Emergency Hospital Mansoura University, Egypt, a prospective observational cohort research was conducted. 118 participants from both sexes who had right iliac fossa (RIF) pain suggestive of appendicitis participated in this study. Results: when compared to the histological findings, the Alvarado score exhibited a sensitivity and specificity of 67.6% and 61.5% respectively, with an accuracy of 58.5% in diagnosing appendicitis. With an accuracy of 79.7%, ultrasonography demonstrated a sensitivity and specificity of 80.4% and 76.9% in detecting appendicitis respectively. When compared to those without appendicitis, the MPV in cases with AA was statistically considerably smaller. The optimum MPV cutoff point for detecting appendicitis cases was less-than 8.92 with a sensitivity of 78.3%, specificity of 61.5%, and accuracy of 66.2%. Conclusion:While the Alvarado score and the combination of the two exhibited lower accuracy, the MPV had a greater accuracy for diagnosis than the Alvarado score. The sensitivity and accuracy of diagnosing acute appendicitis were significantly improved by combining the Alvarado score with the ultrasound examination.

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Section: Discussionsupporting

confidence: 92%

Mean Platelet Volume versus Alvarado Score as Predictor of Acute Appendicitis

2023

The Egyptian Journal of Hospital Medicine

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“…Uyanik et al confirm that MPV in children with acute appendicitis has no diagnostic value [18]. However, Oktay et al found that low MPV showed importance for the diagnosis of acute appendicitis [31]. Bilici et al also reported a significant reduction in MPV in the group of children with acute appendicitis in comparison with the control group [32].…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Red Blood Cell Distribution Width, Mean Platelet Volume and Platelet Distribution Width in Children with Acute Appendicitis

et al. 2021

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Background and Objectives: Acute appendicitis in pediatric patients is one of the most common surgical emergencies, but the early diagnosis still remains challenging. The aim of this study was to determine the predictive value of Red blood cell distribution width (RDW), Mean platelet volume (MPV) and Platelet distribution width (PDW) in children with acute appendicitis. Materials and Methods: This study was a retrospective assessment of laboratory findings (RDW, MPV, PDW) of patients who underwent surgical treatment for acute appendicitis from January 2019 to December 2020. Result: During this period, 223 appendectomies were performed at our Institute. In 107 (43%) cases appendicitis was uncomplicated, while in 116 (46.6%) it was complicated. WBC and RDW/MPV ratio were significant parameters for the diagnosis of acute appendicitis with cut-off values of 12.86 (susceptibility: 66.3%; specificity: 73.2%) and 1.64 (susceptibility: 59.8%; specificity: 71.9%), respectively. WBC and RDW/RBC ratio were independent variables for the diagnosis of complicated appendicitis. The cut-off values were 15.05 for WBC (sensitivity: 60.5%; specificity: 70.7%) and 2.5 for RDW/RBC ratio (sensitivity: 72%; specificity: 52.8%). Conclusions: WBC is an important predictor of appendicitis and complicated appendicitis. RDW, MPV and PDW alone have no diagnostic value in pediatric acute appendicitis or predicting the degree of appendix inflammation. However, the RDW/MPV ratio can be an important predictor of appendix inflammation, with higher values in patients with more severe appendix inflammation. RDW/RBC ratio may be an important predictor of complicated appendicitis.

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“…This retrospective study was conducted in Turkey. It included 207 pediatric patients who were divided into three groups (non-AA, uncomplicated AA, and complicated AA) [ 20 ]. The mean MPV was highest in the non-AA group, and there was a significant difference in the MPV among the groups ( p = 0.047).…”

Section: Resultsmentioning

confidence: 99%

“…This validated 27-point scale has four domains of assessment with minimum and maximum scores of 0 and 32, respectively. Based on these scores, the risk of bias was graded as low (score > 23), moderate (16)(17)(18)(19)(20)(21)(22)(23), or high (0-15). The kappa statistics were used to identify the level of inter-rater agreement regarding the risk of bias [11].…”

Section: Quality Assessmentmentioning

confidence: 99%

Mean Platelet Volume in the Diagnosis of Acute Appendicitis in the Pediatric Population: A Systematic Review and Meta-Analysis

et al. 2022

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Background: Mean Platelet Volume (MPV) has been suggested as a biomarker for acute appendicitis (AA) in the adult population. The utility of MPV in pediatric AA remains vague. This systematic review and meta-analysis aimed to systematically summarize and compare all relevant data on MPV as a diagnostic biomarker for AA in children. Methods: Databases were systematically searched using keywords ((mean platelet volume) OR mpv) AND (appendicitis). The inclusion criteria were all comparative studies of MPV in children aged less than 18 years and diagnosed with AA. Two authors independently assessed the methodological quality using the Downs and Black scale. Results: We included fourteen studies in the final meta-analysis; most were retrospective. Eight studies compared the MPV values between AA and non-AA; four studies compared the same between AA and healthy controls; two studies compared the MPV values among all three groups. The estimated heterogeneity among the studies for all outcomes was high and statistically significant. The pooling the data showed no statistically significant difference in MPV (weighted mean difference (WMD) = −0.42, 95% CI = (−1.04, 0.20), p = 0.19) between AA and healthy controls or AA and non-AA cases (WMD = 0.01, 95% CI = (−0.15, 0.17), p = 0.90). Conclusion: While MPV levels seem to have some utility in adult AA diagnosis, MPV levels should not dictate treatment options in pediatric AA.

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Evaluation of the diagnostic value of platelet indices in pediatric acute appendicitis

Cited by 7 publications

References 32 publications

Mean Platelet Volume versus Alvarado Score as Predictor of Acute Appendicitis

Mean Platelet Volume versus Alvarado Score as Predictor of Acute Appendicitis

Predictive Value of Red Blood Cell Distribution Width, Mean Platelet Volume and Platelet Distribution Width in Children with Acute Appendicitis

Mean Platelet Volume in the Diagnosis of Acute Appendicitis in the Pediatric Population: A Systematic Review and Meta-Analysis

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