Predictive Value of Red Blood Cell Distribution Width, Mean Platelet Volume and Platelet Distribution Width in Children with Acute Appendicitis

Antić, Jelena; Jokić, Radoica; Bukarica, Svetlana; Lukic, Ivana; Dobrijević, Dejan; Rakić, Goran; Pajic, Milos; Trajković, Veličko; Milenković, Marina

doi:10.3390/children8111041

Cited by 7 publications

(13 citation statements)

References 31 publications

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“…While reduced values of this parameter have no major clinical significance, elevated values may indicate destruction and, at the same time, production of new, smaller platelets, because the acute phase inflammatory reactants lead to megakaryopoiesis. 19 , 24 Our research confirmed statistically significantly higher values of this parameter compared to the control group. Shankaralingappa et al reported that PDW was significantly higher in those with COVID‐19 than non‐COVID‐19 controls, and could be used as an additional inflammatory marker.…”

Section: Discussionsupporting

confidence: 80%

“…PDW is a platelet index that indicates their size distribution in percentage. While reduced values of this parameter have no major clinical significance, elevated values may indicate destruction and, at the same time, production of new, smaller platelets, because the acute phase inflammatory reactants lead to megakaryopoiesis 19,24 . Our research confirmed statistically significantly higher values of this parameter compared to the control group.…”

Section: Discussionsupporting

confidence: 73%

“…MPV indicates the average size of an individual platelet, but it can also be used as a marker of inflammation, because platelets are reactively enlarged as part of an inflammatory response, especially in children 19 . According to our research, children with SARS‐CoV‐2 infection had statistically significantly higher platelets compared to children with other respiratory infections, which may indicate a strong activation of platelets caused by proinflammatory cytokines, regardless of the mild clinical picture.…”

Section: Discussionmentioning

confidence: 58%

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Could platelet indices have diagnostic properties in children with COVID‐19?

Dobrijević

Antić

Rakić

et al. 2022

Clinical Laboratory Analysis

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Introduction Viral infections are often accompanied by reactive thrombocytosis, that is, increased activity of platelets, which is especially common in infants and children. Objective This study aimed to test the diagnostic properties of platelet indices, plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW), in children with beta corona virus 2 (SARS‐CoV‐2) infection. Methods The study included 232 patients below the age of 18 admitted to the coronavirus disease (COVID‐19) isolation wards at the Institute for Child and Youth Health Care of Vojvodina. PCT, MPV and PDW values on the day of admission were recorded. In total, 245 controls were selected from those treated for SARS‐CoV‐2 negative respiratory infections. Descriptive and inferential statistical analyses were performed. Results MPV and PDW were found important as independent predictors for COVID‐19 in children. Furthermore, the joint effect of MPV and PDW for predicting COVID‐19 was confirmed. The parameters showed better sensitivity than specificity. Conclusion Our study showed that PCT is not clinically significant, while MPV and PDW have diagnostic value in predicting COVID‐19 in children. In perspective, these parameters could be implemented in the various learning algorithms in order to achieve earlier diagnosis and treatment.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 58%

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Could platelet indices have diagnostic properties in children with COVID‐19?

Dobrijević

Antić

Rakić

et al. 2022

Clinical Laboratory Analysis

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“…One of the most commonly used laboratory parameters when considering the diagnosis of acute appendicitis is the number of leukocytes. Some authors state that the number of neutrophils is a far more sensitive parameter and that neutrophil to lymphocyte ratio can be a useful predictor of complicated appendicitis forms [15,16]. A significant percentage of our subjects (83.64-95.24%) had leukocyte values greater than 10 × 10 9 /L, which is consistent with the diagnosis.…”

Section: Discussionsupporting

confidence: 78%

Comparison of conservative and operative treatment of uncomplicated appendicitis in the pediatric population

et al. 2023

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Introduction/Objective. Studies about possibilities of conservative, i.e. non-operative management of acute uncomplicated appendicitis in adult and pediatric population have been published lately, considering benefits of preserving appendix and potential complications related to appendectomy. Methods. In this retrospective study medical data of 76 patients treated at the Institute for Child and Youth Health Care of Vojvodina in Novi Sad for acute uncomplicated appendicitis in 2015 and 2016 have been analysed, comparing length of stay, antibiotic therapy use, complications occurement, as well as the financial burden depending of the type of therapy applied. Results. During this period, 76 patients (55 operated and 21 treated conservatively) were treated for acute uncomplicated appendicitis. Conservatively treated children spent statistically significantly shorter period of time at the hospital compared to the operated ones (4.24 vs. 5.76 days; p < 0.001). Early surgical complications occurred in 10.91% operated and 9.52% non-operated children, which wasn?t statistically significant difference (p = 0.863). The total cost of hospital stay was significantly lower in those who underwent non-operative management (10,340 RSD vs. 54,281 RSD; p = 0). The difference was significant even when analyzing costs related to rehospitalization and operative treatment of children initially treated conservatively (p < 0.001). Conclusion. Non-operative i.e. conservative treatment of acute uncomplicated appendicitis in the pediatric population is safe and effective compared to the operative one, and it is not associated with more frequent occurrence of early surgical complications. Total costs for the non-operative treatment are significantly lower, even considering costs related to re-hospitalization of children initially treated conservatively.

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“…Some studies have shown that high RDW levels can be seen in various pathological conditions. However, in studies on the differential diagnosis of AA and determining the severity of appendicitis in children, a superiority of RDW over other parameters has not been demonstrated [17,18]. In studies conducted on adults, RDW was not found to be significant in the differential diagnosis between AA and ureteral Stones [8,9].…”

Section: Discussionmentioning

confidence: 99%

Can Neutrophil-Lymphocyte Ratio in Complete Blood Count Help in the Differential Diagnosis Between Acute Appendicitis and Right Ureteral Stones in Pediatric Age Groups?

Kocaman

Yağmur

Günendi

et al. 2022

Cureus

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Background and objectiveAbdominal pain is one of the most common problems in children presenting to the pediatric emergency departments and is often a diagnostic challenge for the physician. Clinical studies have been carried out on adult patients to differentiate between ureteral stones and acute appendicitis (AA) in which neutrophillymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were analyzed in the complete blood count, and it was found that NLR and PLR could help in the differential diagnosis. In this study, we investigated whether complete blood count parameters in pediatric patients could be helpful in the differential diagnosis between AA and right ureteral stones. MethodsThe files of pediatric patients who were followed up and treated for AA and right ureteral stones between January 2019 and March 2021 were reviewed retrospectively. The demographic characteristics of the patients and their WBC, NLR, PLR, and red cell distribution width (RDW) values were evaluated to determine whether there was a difference between the two groups. ResultsIn this study, 77 patients with AA and 48 patients with right ureteral stones were included. Univariate regression analysis revealed that age, gender, WBC, PLR, and NLR were factors likely responsible for AA. As per multivariate linear regression analysis, NLR level (odds ratio: 0.407; 95% CI: 0.293-0.566; p<0.001) was an independent predictor of AA. ConclusionBased on our findings, NLR can help in establishing the diagnosis in pediatric patients who present to the emergency department with right lower quadrant pain, and in whom physical examination, routine laboratory tests, and imaging methods cannot help distinguish between AA and ureteral stones.

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Predictive Value of Red Blood Cell Distribution Width, Mean Platelet Volume and Platelet Distribution Width in Children with Acute Appendicitis

Cited by 7 publications

References 31 publications

Could platelet indices have diagnostic properties in children with COVID‐19?

Could platelet indices have diagnostic properties in children with COVID‐19?

Comparison of conservative and operative treatment of uncomplicated appendicitis in the pediatric population

Can Neutrophil-Lymphocyte Ratio in Complete Blood Count Help in the Differential Diagnosis Between Acute Appendicitis and Right Ureteral Stones in Pediatric Age Groups?

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