Evaluation of the diagnostic value of the renal resistive index as a marker of the subclinical development of cardiorenal syndrome in MMVD dogs

Szczepankiewicz, Barbara; Pasławska, Urszula; Siwińska, Natalia; Plens, Krzysztof; Pasławski, Robert

doi:10.1177/1470320321995082

Cited by 9 publications

(11 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In women, higher systolic blood pressure and body weight were associated with higher RI values, whereas increases in heart rate were associated with lower RI values 52 . Correlations between sex, body weight, heart rate, and systolic blood pressure were not observed in dogs 39,53 . The influence of sex and body weight on the RI of cats is still not clear and only one study reported a positive correlation between body weight and index for the species 39…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Resistivity and pulsatility indexes in feline kidney disease: a systematic review

Evangelista

Viana

Neves

et al. 2022

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Doppler ultrasonography is used in the evaluation of hemodynamics, and the resistivity (RI) and pulsatility (PI) indexes provide information about resistance to blood flow within a vessel. This systematic review was carried out to evaluate renal RI and PI in clinically healthy and nonsedated cats and as well as their usefulness in the evaluation of kidney disease in cats. An electronic search in the PubMed, Scopus, and Web of Science databases was carried out using the terms "resistive index" or "resistivity index" or "pulsatility index;" "Doppler;" "renal" or "kidney;" and "cat" or "feline" in titles, abstracts, and keywords. Variables of interest related to experimental model features, research methods, and technical resources were extracted from the studies. The methodological quality was assessed with SYRCLE's risk of bias tool. Thus, 14 studies involving healthy and sick cats were selected. Interestingly, the upper limits estimated for both RI and PI varied among studies. The upper limits of renal RI for healthy cats varied between 0.64 and 0.72, while for PI, the values varied from 1.06 to 1.29. A limited number of studies evaluated cats with kidney disease. In most studies, RI values of kidneys with different conditions were significantly different from kidneys of healthy animals, indicating that RI values increase with kidney disease. The parameters body weight, heart rate, and age seem to influence the RI values. Standardized studies regarding its realization and description are still necessary to define normal values and analyze its applicability in the clinical diagnostic routine.

show abstract

Section: Discussionmentioning

confidence: 95%

“…52 Correlations between sex, body weight, heart rate, and systolic blood pressure were not observed in dogs. 39,53 The influence of sex and body weight on the RI of cats is still not clear and only one study reported a positive correlation between body weight and index for the species. 39…”

Section: Discussionmentioning

confidence: 99%

Resistivity and pulsatility indexes in feline kidney disease: a systematic review

Evangelista

Viana

Neves

et al. 2022

Vet Radiology Ultrasound

View full text Add to dashboard Cite

show abstract

“…As the functions of the heart and kidneys are closely related to fluid regulation, and failure of one organ leads to a loss of function of the other, this condition is termed cardiorenal syndrome (CRS) (Ronco et al 2008). In dogs, renal failure secondary to cardiac disease is also known as CRS (Szczepankiewicz et al 2021). Cardiac output is reduced in dogs with myxomatous mitral valve disease, leading to a decreased GFR and exacerbation of azotaemia (Nicolle et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Association between glomerular filtration rate and plasma N‐terminal pro‐atrial natriuretic peptide concentration in dogs

Ogawa

Nohara

Hsu

et al. 2023

J of Small Animal Practice

View full text Add to dashboard Cite

ObjectivesTo investigate the association between plasma N‐terminal pro‐atrial natriuretic peptide concentration and glomerular filtration rate in dogs.Materials and MethodsDogs were classified into four categories by bodyweight. Dogs were divided into four groups (Groups 1 to 4) based on glomerular filtration rate estimates using plasma iohexol clearance per bodyweight category. Generalised linear models were built to explore the relationship between plasma N‐terminal pro‐atrial natriuretic peptide concentration and glomerular filtration rate and the effect of confounders on plasma N‐terminal pro‐atrial natriuretic peptide concentration.ResultsFifty‐three dogs were included (Group 1, 25; Group 2, seven; Group 3, five; and Group 4, 16). The medians (interquartile range) N‐terminal pro‐atrial natriuretic peptide concentrations for Groups 1 to 4 were 7224 pg/mL (4766 to 10,254 mg/dL), 8958 pg/mL (4935 to 11,271 mg/dL), 9280 pg/mL (9195 to 10,384 mg/dL) and 12,683 pg/mL (9133 to 19,217 mg/dL), respectively. Group 4, estimated to have the highest reduction in glomerular filtration rate, had a higher plasma N‐terminal pro‐atrial natriuretic peptide concentration than Groups 1 to 3. Based on the final generalised linear model, influencing factors for plasma N‐terminal pro‐atrial natriuretic peptide concentration were plasma iohexol clearance (−0.136; 95% confidence interval, −0.227 to −0.046) and bodyweight (−0.058; 95% confidence interval, −0.098 to −0.018).Clinical SignificanceN‐terminal pro‐atrial natriuretic peptide concentration is associated with the glomerular filtration rate.

show abstract

“…Szczepankiewicz et al. have reported that RI is useful in detecting kidney injury in dogs with MMVD 14 . However, no study has yet focused on VII and IRVF patterns in dogs.…”

Section: Introductionmentioning

confidence: 99%

The repeatability, reproducibility, and influencing factors of intrarenal Doppler ultrasonography in dogs without heart disease

Terukina

Morita

Yamasaki

2022

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Renal impairment is concurrent with adverse outcomes such as heart disease in humans and dogs. Intrarenal Doppler ultrasonography (IRD) is used to assess intrarenal hemodynamics, and resistance index (RI) and venous impedance index (VII) are used to evaluate intrarenal hemodynamics in humans with heart failure. However, only a few studies have assessed the efficacy of IRD, especially VII, in dogs, and the methods differ between studies. Additionally, repeatability, reproducibility, and factors influencing IRD values have not been validated in dogs. This prospective, analytical study aimed to assess repeatability and reproducibility of IRD, and to clarify influencing factors of IRD in dogs without heart disease. We enrolled 78 dogs without heart disease. The RI and VII were highly reproducible, and the reference intervals for VII were 0.13-0.37. Differences in transducer (sector and convex) and posture (right lateral and supine decubitus position) had no effect on the IRD values. In contrast, RI and VII were higher in the renal vessels than in interlobar vessels. Age affected RI values (r = 0.39, P < 0.001), but there was no correlation between age, body weight, and VII. In conclusion, IRD is a repeatable and reproducible method to assess intrarenal hemodynamics in dogs. The findings also suggest that age should be considered while interpreting RI.

show abstract

Evaluation of the diagnostic value of the renal resistive index as a marker of the subclinical development of cardiorenal syndrome in MMVD dogs

Cited by 9 publications

References 41 publications

Resistivity and pulsatility indexes in feline kidney disease: a systematic review

Resistivity and pulsatility indexes in feline kidney disease: a systematic review

Association between glomerular filtration rate and plasma N‐terminal pro‐atrial natriuretic peptide concentration in dogs

The repeatability, reproducibility, and influencing factors of intrarenal Doppler ultrasonography in dogs without heart disease

Contact Info

Product

Resources

About