Evaluation of the diuretic activity of the ethanolic extract of Geranium seemannii Peyr. in Wistar rats

Montejano-Rodríguez, José Ramón; Almaguer-Vargas, Georgina; Gayosso-de-Lucio, Juan A.; Hernández, María Esther Ocharan; Martínez, Reyna Erika Moreno; Caballero, Marta Elena Hernández; Torres-Valencia, J. Jesús Martín; Ramírez, José Alfredo Sierra

doi:10.1016/j.jopr.2013.07.013

Cited by 9 publications

(12 citation statements)

References 17 publications

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“…, electrolytes) in the urine. These processes may result from suppression of renal tubular reabsorption of water and electrolytes into the blood stream [33]. This study put forth the diuretic potential of N. sativa and N. damascena 70% ethanolic extracts.…”

Section: Resultsmentioning

confidence: 99%

Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds

et al. 2015

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Abstract:This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed using a HPLC-UV/MS method. Hyperoside was the only identified flavonoid glycoside (1.08 ± 0.01 μg·g dw plant material). The antioxidant potential of the two species was tested through several electron transfer assays, which indicated, excepting for the FRAP assay, N. damascena as exhibiting a higher free radical scavenging activity. The diuretic activity of the two extracts was tested using a rat-experimental model on acute diuresis. Administration of the ethanolic extract of N. sativa (100 mg·kg −1 ) resulted in a significant increase in urine volume, although less than found with the reference drug; in OPEN ACCESSMolecules 2015, 20 9561 addition N. damascena extract did not present a diuretic effect. In reference to the elimination of Na + , K + and uric acid, the black cumin extract exhibited a higher natriuretic than kaluretic effect and a similar uricosuric effect with control and N. damascena. For N. damascena, the Na + /K + ratio was sub unitary, but not due to an increasing of the kaluretic effect, but mostly to a decrease of Na + excretion.

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Section: Resultsmentioning

confidence: 99%

Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds

et al. 2015

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“…Phytochemical analysis showed that asafoetida consists of phenolic compounds such as ferulic acid and its esters, coumarins, sesquiterpene coumarins and other terpenoids. [18] Flavonoids have shown a diuretic effect, and several flavonoids have been reported to inhibit Na-K-2Cl co-transporter, as well as an increase in natriuresis and kaluresis. [1920] In an experimental study, hypotensive and vasodilatory effects of F. assa-foetida gum extract has reported.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ferula assa-foetida oleo-gum-resin on renal function in normal Wistar rats

Bagheri¹,

Mohammadsadeghi²,

Dashti-R³

et al. 2016

Indian J Nephrol

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In traditional Iranian medicine, asafoetida, an oleo-gum-resin obtained from the roots of Ferula assa-foetida, has been prescribed as a diuretic. This study was undertaken to investigate the diuretic effect of asafoetida in normal rats. Asafoetida was administered orally at the doses of 25 and 50 mg/kg and furosemide (10 mg/kg, intraperitoneal) was used as positive control. The diuretic effect was evaluated by measuring urine volume and sodium, potassium, urea, and creatinine content in urine and serum. Urine volume, excretion of sodium, and potassium were significantly increased by asafoetida as compared to the control group. A significant increase in creatinine clearance was observed in the groups treated with asafoetida at the doses of 25 and 50 mg/kg (P < 0.05). We conclude that asafoetida induced a diuretic effect comparable to that produced by the reference diuretic furosemide. This study provides a quantitative basis for explaining the folkloric use of asafoetida as a diuretic agent.

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“…Previous studies demonstrated that several secondary metabolites of plants could be responsible for the diuretic effects, such as flavonoids, alkaloids, tannins, saponins, terpenoids or organic acids (Jabeen and Aslam, 2013). Several isoflavonoids have been reported to cause inhibition of the Na + -K + -2Cl -co-transporter, an increase in diuresis, natriuresis, glomerular filtration and and Na + and K + excretion (Montejano-Rodrı´guez et al, 2013). Thus, phenolic and flavonoids compounds evaluated in O. glandulosum may be considered as responsible for this diuretic effect because of its high phenolic content.…”

Section: Discussionmentioning

confidence: 99%

In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

Bouaziz

Khennouf

Zarga

et al. 2019

Bangladesh J Pharmacol

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In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat BJP Thus, much attention has been paid to the study of medicinal plants, including the screening of natural bioactive compounds such as phenolic compounds with the ability to cure, prevent the progression of many diseases (Yadegarinia et al., 2006) and the exploration of traditional medicines may reveal new treatment options to increase the therapeutic arsenal by the discovery of novel medicines and to offer lower cost alternatives in developing countries that increasingly AbstractThe objective of this study was to evaluate the in vitro anti-oxidant, hypotensive and the diuretic activities of Origanum glandulosum leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3methylphenol. Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of O. glansulosum in traditional medicine as hypotensive and diuretic agents. Article Info

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Evaluation of the diuretic activity of the ethanolic extract of Geranium seemannii Peyr. in Wistar rats

Cited by 9 publications

References 17 publications

Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds

Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds

Effect of Ferula assa-foetida oleo-gum-resin on renal function in normal Wistar rats

In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

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