In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

Bouaziz, Amel; Khennouf, Seddik; Zarga, Musa Abu; Abdalla, Shtaywy

doi:10.3329/bjp.v14i1.38089

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The obtained results may be due to the presence of polyphenols and flavonoids which have the principal contribution to the antioxidant capacity of fruits extracts. In fact, literature showed that good correlation was found between antioxidant activity and the content of polyphenols and flavonoids contents 19,29 . Albano and Miguel 30 reported that flavonoids and phenolic acids are more effective in scavenging free radicals after extraction with moderate or hydrophilic solvents.…”

Section: Hydroxyl Radical Scavenging Activitymentioning

confidence: 99%

Phenolic content and antioxidant activity of ethanolic extracts from Citrus sinensis L. and Citrus reticulata L. fruits

Bentahar

Bouaziz

Djidel

et al. 2020

J. Drug Delivery Ther.

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Citrus fruits, in particular the genus Citrus, are very rich in antioxidants which have beneficial effects on human health. The objective of this study was to evaluate the phenolic content and the antioxidant activity of the ethanolic extracts from orange (Citrus sinensis L.) and mandarin (Citrus reticulata L.) fruits. The quantitative estimation of the total phenolic content in the two extracts revealed their richness in these compounds. The results obtained showed that the polyphenols content were 159.66 ± 2.62 mg GAE / g of dry extract and 127.33 ± 2.32 mg GAE / g of dry extract for C. sinensis and C. reticulata, respectively.The quantification of flavonoids content showed that the ethanolic extracts of C. sinensis and C. reticulata contained 0.85 ± 0.01 mg QE / g of dry extract and 0.876 ± 0.073 mg QE / g of dry extract, respectively. Whereas, the tannins contents were 46.32 ± 1.02 mg TAE / g of dry extract for C. sinensis and 47.65 ± 1.36 mg TAE / g of dry extract for C. reticulata. In vitro antioxidant activity was evaluated using two tests: the reducing power and the hydroxyl radical scavenger test. The evaluation of the two extracts by the ferric iron reducing power test showed an EC50 value of 0.882 ± 0.037 mg / ml for C. sinensis extract and an EC50 of 1.085 ± 0.068 mg / ml for C. reticulata extract. In addition, C. sinensis and C. reticulata showed good hydroxyl radical scavenging effect with IC50 values of 0.303 ± 0.026 mg /ml and 0.572 ± 0.100 mg / ml for C. sinensis and C. reticulata, respectively. These results suggested that these fruit extracts could be good sources of phenolic compounds and ingredients with high antioxidant potential. Keywords: Citrus sinensis, Citrus reticulata, Polyphenols, Flavonoids, Tannins, Antioxidant activity.

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Section: Hydroxyl Radical Scavenging Activitymentioning

confidence: 99%

Phenolic content and antioxidant activity of ethanolic extracts from Citrus sinensis L. and Citrus reticulata L. fruits

Bentahar

Bouaziz

Djidel

et al. 2020

J. Drug Delivery Ther.

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“…Hydroxyl free radicals have been implicated in the etiology of much pathology and eventually resulted in the cell injury/death. Therefore, the scavenging of hydroxyl radicals by extracts may provide a significant protection to biomolecules against free radicals 25 .…”

Section: Hydroxyl Radical Scavenging Activitymentioning

confidence: 99%

In vitro antioxidant activity and gastroprotective effect of ethanolic extract from Cucumis melo L. var. inodorus fruit on ethanol-induced gastric ulcer in rats

Bouaziz

Bentahar

Djidel

et al. 2020

J. Drug Delivery Ther.

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The aim of this study was to estimate the content of polyphenols, flavonoids and tannins and to evaluate the antioxidant property and the antiulcer activity of the ethanolic extract of melon (Cucumis melo L. var. inodorus) pulp on ethanol-induced gastric ulcers in rats. Ferric reducing power and hydroxyl radical scavenging tests were applied to evaluate the in vitro antioxidant activity. The polyphenolic and flavonoids contents of melon extract were found to be 56.5 ± 2.49 mg GAE/g of dry extract and 0.43 ± 0.09 mg QE/ g of dry extract, respectively. Whereas the tannins content was 48. 30 ± 0. 9 mg ETA/ g of dry extract. Melon pulp extract exhibited a good reducing potential with an EC50 of 4.23 ± 0.08 mg/ml and high hydroxyl radical scavenging activity with IC50 of 1.83± 0.09 mg/ml. Oral administration of the melon pulp extract at doses of 200 and 600 mg/kg to rats reduced gastric mucosal lesions dose-dependently with percentage protection of 56.56 and 93.79% compared to omeprazole (95.92 %) as reference drug. These results showed that the melon pulp extract had a good antioxidant activity and gastroprotective potential suggesting it use as an adjuvant in the treatment of gastric ulcer. Keywords: Cucumis melo var. inodorus, Polyphenols, Flavonoids, Tannins, Ulcer, Rat.

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Role of Plant Bioactive as Diuretics: General Considerations and Mechanism of Diuresis

Manvi

Khan

Badruddeen

et al. 2023

CHYR

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Background: Medicinal plants have been found beneficial in the control and therapy of many ailments as they contain bioactive compounds, and many of them are used as precursors in the biosynthesis of natural medicines. Diuretics are used as a primary treatment in patients with edema associated with liver cirrhosis and kidney diseases, hyperkalemia, hypertension, heart failure, or renal failure. Furthermore, they are also used to increase the excretion of sodium and reduce blood volume. Due to various adverse events associated with synthetic diuretics, there is a need to investigate alternate plant-based bioactive components that have effective diuretic activity with minimal side effects. Objective: This review compiled the reported bioactive compounds from different plant sources along with their mechanisms of diuretic activity. Methods: Different sources were used to collect information regarding herbal plants with therapeutic value as diuretics. These included published peer-reviewed journal articles, scholarly articles from StatPearls, and search engines like Google Scholar, PubMed, Scopus, Springer, ScienceDirect, Wiley, etc. Results: In this review, it was found that flavonoids like rutin, acacetin, naringenin, etc. showed significant diuretic activity in experimental models by various mechanisms, but mostly by blocking the sodium-potassium-chloride co-transporter, while some bioactive compounds showed diuretic actions via other mechanisms as well. Conclusion: Research on clinical trials of these isolated bioactive compounds needs to be further conducted. Thus, this review provides an understanding of the potential diuretic bioactive compounds of plants for further research and pharmaceutical applications.

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In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

Cited by 3 publications

References 23 publications

Phenolic content and antioxidant activity of ethanolic extracts from Citrus sinensis L. and Citrus reticulata L. fruits

Phenolic content and antioxidant activity of ethanolic extracts from Citrus sinensis L. and Citrus reticulata L. fruits

In vitro antioxidant activity and gastroprotective effect of ethanolic extract from Cucumis melo L. var. inodorus fruit on ethanol-induced gastric ulcer in rats

Role of Plant Bioactive as Diuretics: General Considerations and Mechanism of Diuresis

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