Evaluation of the Dose Range of Etoricoxib in an Acute Pain Setting Using the Postoperative Dental Pain Model

Abstract

Etoricoxib (90 and 120 mg) showed similar efficacy in the postoperative dental pain model, which was noninferior to ibuprofen and superior to A/C. A higher number of tooth extractions or a higher mean impaction score may have led to a greater separation in efficacy between the 2 etoricoxib doses.

A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120mg on inflammatory events following removal of unerupted mandibular third molars

“…14 Although some adverse effects related to the use of NSAIDs such as gastrointestinal bleeding, renal function disturbances, a reduction in platelet function, shortness of breath, and profound hypotension have been described in the literature, 5,13 the oral intake of NSAIDs has been recommended by some authors as an efficient pre-emptive therapeutic regimen. 6,15,16 A recent study has demonstrated etoricoxib to be an efficient drug for the management of acute pain secondary to primary dysmenorrhoea and oral and orthopaedic surgeries, 17 and etoricoxib at 120 mg has shown efficacy in several non-dental clinical trials as a pre-medication to control acute postoperative pain. [18][19][20][21][22] Two recently published Cochrane reviews evaluated the analgesic efficacy of a single postoperative dose of etoricoxib in a dental pain model.…”

“…23,24 However, evidence of the efficacy of pre-emptive analgesia after third molar surgery remains scarce, and to date, there has been only one non-placebo controlled study that has evaluated the pre-emptive analgesic effect of this drug in third molar surgery. 12 Etoricoxib is a potent and selective cyclo-oxygenase 2 (COX-2) inhibitor with few gastrointestinal side effects 17 and with favourable pharmacological properties, and may thus be considered a promising drug for pre-emptive analgesia.…”

The effectiveness and safety of nonsteroidal anti-inflammatory drugs

“…Показано, что применение этих препаратов перед травматичными вмешательствами открывает возможность не только подавлять уже возникшую боль, но и проводить ак-тивную профи лактику ее развития, повышает ак-тивность препаратов, используемых для местной и общей анестезии, значительно снижает в тканях уровень медиаторов воспаления, уменьшая выра-женность послеоперационной воспалительной ре-акции и интенсивность последующих болевых ощу-щений, что позволяет снизить потребность в опио-идных анальгетиках [5,16,17,21,24,28,30,32,39,44,45,62].…”

Eficácia analgésica da associação de 30mg do fosfato de codeína com 500mg do paracetamol após exodontias de terceiros molares inferiores impactados

“…A maioria dos estudos adota o sistema de avaliação da EVA em diferentes momentos, sendo estas avaliações concentradas nas primeiras 24 horas de pós-operatório (Jung et al, 2004;Chang et al, 2005;Daniels et al, 2011;Gatoulis et al, 2012 opções mais utilizadas para a prevenção do edema é a administração pré-operatória dos costicosteróides, seja via oral, submucosa, intravenosa ou muscular (Alexander;Throndson, 2000;Antunes et al, 2011;Klongnoi et al, 2012;Bauer et al, 2013;Herrera-Briones et al, 2013;Darawade et al, 2014).…”

“…Alguns estudos já compararam a eficácia analgésica da codeína associada ao paracetamol com outros fármacos após exodontias de terceiros molares impactados (Jung et al, 2004;Chang et al, 2005;Daniels et al, 2011;Gatoulis et al, 2012;Brown et al, 2013). No entanto, é importante analisar a eficácia analgésica dessas substâncias quando se encontram associadas, e também a intensidade dos efeitos colaterais, em busca de doses e dosagens que estejam de acordo com as necessidades do paciente.…”