Evaluation of the Effect of Lansoprazole in Suppressing Acid Secretion Using 24-Hour Intragastric pH Monitoring

Takeda, Hiroshi; Hokari, Kaku; Asaka, Masahiro

doi:10.1097/00004836-199506001-00003

Cited by 23 publications

(13 citation statements)

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“…The results obtained in this study are similar to a prior investigation 57 that compared the acid inhibitory acitivity of omeprazole, lansoprazole, and famotidine. Ten healthy volunteers were treated sequentially with lansoprazole, 30 mg once daily in the morning; famotidine, 20 mg twice daily; and omeprazole, 20 mg once daily in the morning.…”

Section: Review Of Selected Intragastric Ph Studiessupporting

confidence: 88%

“…Comparisons between lansoprazole and omeprazole and between both doses of omeprazole revealed no significant difference in median intragastric pH and the time over pH 4.0. 57 Blum et al 42 recently compared 2-dose regimens of lansoprazole to omeprazole and to ranitidine at the recommended dose for the treatment of erosive esophagitis. This was a randomized, double-blind, 4-way crossover study in 29 healthy male volunteers comparing the effects on intragastric pH of lansoprazole, 15 mg once daily, lansoprazole, 30 mg once daily, omeprazole, 20 mg once daily, and ranitidine, 150 mg 4 times daily.…”

Section: Review Of Selected Intragastric Ph Studiesmentioning

confidence: 99%

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Importance of pH Control in the Management of GERD

Hunt¹

1999

Arch Intern Med

179

128

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The degree of esophageal mucosal injury that occurs in patients with gastroesophageal reflux disease depends on duration of exposure and pH of the refluxate. Evidence suggests that an intraesophageal pH of less than 4.0 directly correlates with the degree of mucosal injury. The advent of acid secretory inhibitors such as the histamine2-receptor antagonists (H2RAs) and, more recently, the proton pump inhibitors (PPIs) has revolutionized the treatment of patients with reflux disease. However, the evidence linking the degree of mucosal damage to pH of the refluxate has prompted investigators to reevaluate the effectiveness of these agents. The PPIs are significantly more effective than the H2RAs in achieving and sustaining an intragastric pH above 4.0. The results of clinical trials performed with the PPIs indicate a faster rate of healing of erosive esophagitis and of symptom relief than treatment with H2RAs.

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Section: Review Of Selected Intragastric Ph Studiessupporting

confidence: 88%

Section: Review Of Selected Intragastric Ph Studiesmentioning

confidence: 99%

Importance of pH Control in the Management of GERD

Hunt¹

1999

Arch Intern Med

179

128

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“…Furthermore, the cure rate in Group 1L, in which lansoprazole 30 mg was used instead of OPZ 20 mg, was higher than that of Group 1 although there was no significant difference except APT based cure rate in Table 3. The degree of acid suppression by OPZ 20 mg or lansoprazole 30 mg a day remains controversial [23][24][25]. Yet, the higher cure rate in Group 1L may possibly be due to the greater acid suppressive effect in Japanese subjects [25] and/or the more potent anti-bacterial activity of 30 mg lansoprazole [26] than that of 20 mg OPZ.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Omeprazole‐Amoxicillin‐Clarithromycin (OAC) Therapy for Helicobacter pylori Infection in a Japanese Population

et al. 1998

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“…Proton pump inhibitors suppress acid secretion more strongly than H 2 -receptor antagonists (Savarino et al 1993;Takeda et al 1995), and increase mucosal blood¯ow more than H 2 -receptor antagonists (Holm 1988). Omeprazole, a proton pump inhibitor, and its acid degradation products inhibit cytotoxic activity of human natural killer cells in-vitro (Aybay et al 1995).…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Effect of Proton Pump Inhibitors on Helicobacter pylori-positive Gastric Ulcers

Sasakii

Yokoyama

et al. 1999

Journal of Pharmacy and Pharmacology

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The aim of the present study was to elucidate the risk factors that could delay gastric ulcer healing when either a proton pump inhibitor or an H2-receptor antagonist is used for gastric ulcer treatment. Endoscopically-diagnosed gastric ulcer patients (216 men and 96 women, mean age: 57+/-13 years) were investigated. All patients were consecutively recruited and randomly assigned to receive H2-receptor antagonist (n = 196) or proton pump inhibitor (n = 116) treatment for eight weeks. Chi-squared tests and multivariate analysis to determine factors influencing ulcer healing were used to analyse the patients profiles, endoscopic findings, and Helicobacter pylori-infection status. In the H2-receptor antagonist group, the most important risk factor was a large ulcer size (> 2 cm diam.), followed by a linear shape of the ulcer, undermining tendency of ulcer, previous history of gastric ulcer, and H. pylori infection. In the proton pump inhibitor group, linear shape of the ulcer was the only significant risk factor for slow ulcer healing; other factors, including H. pylori infection, were insignificant. These results indicate that ulcer morphology may be the most important information for predicting ulcer healing, and that H. pylori infection does not delay gastric ulcer healing when proton pump inhibitor treatment is used.

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Evaluation of the Effect of Lansoprazole in Suppressing Acid Secretion Using 24-Hour Intragastric pH Monitoring

Cited by 23 publications

References 0 publications

Importance of pH Control in the Management of GERD

Importance of pH Control in the Management of GERD

Effectiveness of Omeprazole‐Amoxicillin‐Clarithromycin (OAC) Therapy for Helicobacter pylori Infection in a Japanese Population

The Therapeutic Effect of Proton Pump Inhibitors on Helicobacter pylori-positive Gastric Ulcers

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