Evaluation of the effect of dose-dependent platelet-rich fibrin membrane on treatment of gingival recession: a randomized, controlled clinical trial

Abstract

Miller's class I gingival recessions (GR) have been treated using coronally advanced flap (CAF) with platelet-rich fibrin membrane (PRF membrane) or connective tissue graft (CTG).Objective:The aim of this study was to evaluate the effect of different multiple layers of PRF membranes for the treatment of GR compared with the CTG procedure.Material and Methods:Sixty-three Miller class I GR were treated in this study. Twenty-one GR selected randomly were treated with two layers of PRF membranes+CAF in 2PRF+CAF (test group-1), four layers of PRF membranes+CAF in 4PRF+CAF (test group-2), and CTG+CAF in the control group. The plaque index (PI), gingival index (GI), probing depth (PD), keratinized tissue thickness (KTT), clinical attachment level (CAL), recession depth (RD), recession width (RW), and keratinized tissue height (KTH) measurements were performed at baseline and 1, 3, and 6 months after surgery. The post-operative discomfort of patients, assessed with the visual analog scale (VAS) and healing index (HI), was recorded after surgery.Results:PI, GI, and PD scores were similar for all patients at all times. RD and RW scores were similar for each patient at 1 month, but these values were significantly increased in the subsequent periods in test group-1. The increase in KTT was significantly higher in the control group compared with the test groups. Similar root coverage scores were obtained in the test group-2 and control groups, and these scores were significantly higher compared with test group-1.Conclusions:The PRF membrane+CAF technique may be an alternative to the CTG+CAF technique for postoperative patient comfort. However, PRF membranes should use as many layers as possible.

Comparison of Connective Tissue Graft and Platelet Rich Fibrin as Matrices in A Novel Papillary Augmentation Access: A Randomized Controlled Clinical Trial

“…Although the amount of PRF were reported to influence the treatment outcome, quantification of PRF was not done in the present study. 31…”

Miller Class III root coverage with coronary tissue repositioning associate with conjunctive graft

“…After six months, the group of patients who received connective tissue grafts had better total root coverage results when compared to the other group analyzed in this clinical study. However, the group of individuals submitted to graft flap advancement also presented longer surgical time, greater postoperative morbidity and greater need for analgesic medication 15 .…”

Utilização da fibrina rica em plaquetas como opção de tratamento de recessões gengivais – uma análise integrativa da literatura

“…A matriz de fibrina rica em plaquetas (PRF) tem a capacidade de proteger feridas abertas (MARTINS et al, 2017), e, principalmente, de acelerar a cicatrização tecidual (LEBARBENCHON et al, 2019), por meio do controle do processo inflamatório, da liberação gradativa de citocinas e de fatores de crescimento, do estimulo da síntese de fibroblastos e de colágeno, e também da estimulação da angiogênese e da migração epitelial (MARTINS, 2017;MACEDO, 2019;CULHAOGLU, 2018).…”

“…À vista disso, com o intuito de aumentar o conforto do paciente no pós-operatório (CULHAOGLU et al, 2018), a aceitação do mesmo pelo procedimento cirúrgico (REINO et al, 2011) e a eficácia da cobertura de raiz, estão sendo propostas diversas abordagens terapêuticas adicionais para o recobrimento radicular (ROSADO et al, 2015). Pode-se citar o uso da matriz dérmica acelular, da matriz colágena suína, de proteínas derivadas da matriz do esmalte (REINO, 2011;ROSADO, 2015) e, dentre as técnicas mais atuais, há a utilização de derivados plaquetários, principalmente a Fibrina Rica em Plaquetas (PRF) (LEBARBENCHON, 2019;CULHAOGLU, 2018;AROCA, 2009;EREN, 2014).…”

“…Considerando as propriedades da membrana de PRF, vários autores (CHOUKROUN, 2006;MARTINS, 2017;MACEDO, 2019;MALLMANN, 2013) relatam as diversas aplicações intraorais e extraorais desse biomaterial. Entre as aplicações extraorais se destaca as cirurgias plásticas faciais e entre as intraorais, o levantamento de seio maxilar, o preenchimento de alvéolos pós exodontias, em cirurgias para instalação de implantes, em procedimentos de endodontia em dentes jovens e atualmente em recobrimentos radiculares (CULHAOGLU, 2018;AROCA, 2019).…”