Evaluation of the effect of preemptive administration of Rosa damascena extract on post-operative pain in elective cesarean sections

Abstract

Pain is the most common complaint in any kind of disorder. Despite its different nature, place and cause in various cases, pain is the main complaint of about half of the patients that are referred to physicians. Opiates and non-steroidal anti-inflammatory drugs, NSAIDS have been used for pain control many years ago, but these drugs also have some side effects. Regarding the complications and continuous pain in preoperative patients, some safe analgesics with better effects and little adverse effects are needed. Since many years ago in Iran, rose extract products are used in food production as jam and soft drink, and also in traditional medicine. The aim of the current research is to evaluate the effectiveness of preemptive prescription of rose extract in patients with elective cesarean sections (because of its little side effects) and compare its effects with placebo prescription. In a double blind placebo-controlled clinical trial, 92 patients had been studied in 2 equal groups. Group A were given rosehip extracts capsule and Group B were given placebo capsules. After preemptive prescription of Capsules A and B (15 min before anesthesia), the pain score was evaluated with visual analog scale (VAS) in varied hours after surgery in the ward, and then, the findings were analyzed. Analgesic drugs are needed for the palliation of post-operation pain. Total dosage of analgesics and the severity of pain in Group A at any time were lower than in Group B. There are no significant side effects in both groups. The initiation of breast feeding and its effects on newborns were same in both groups. According to our study, rosehip extract can be used in elective surgical patients without any significant side effects in order to improve pain and it is a more effective product when compared with NSAIDS and opiates.

Effects of Topical Application and Oral Intake of Rosa damascena on Acute Pain in Adults: A Systematic Review and Meta-analysis

“…All studies recorded only pain severity, except one which recorded frequency and dosage of administrated analgesics in addition to pain severity. 30 One study suggested an association of mild allergic rhinitis with R damascena therapy [ Table 2 ]. 35 …”

“…Of the seven studies that investigated R damascena in oral form, five administered soft or hard gelatin capsule containing either 200–800 mg extract 25 , 26 , 30 or 2 mL essential oil. 27 , 28 Two remaining studies used 1 mL or 1.5 mL oral drop.…”

“…From the perspective of risk of bias, three out of 11 studies had good quality (low risk of bias for all items), 25 , 27 , 28 while two had poor quality (high risk of bias in one item and unclear risk of bias in more than two items). 30 , 32 The remaining six studies had fair quality (high risk of bias in one item or unclear risk of bias in one item or two items) [ Figures 4 and 5 , Table 4 ]. 24 , 26 , 29 , 31 , 35 , 36 …”

“…In the following, contact was made with the authors via phone call and the required details were obtained. Regarding one study, 30 where the contact number of the author was not available, estimations were made based on our internal discussion and consensus. Secondly, according to pool data using meta-analysis, we compared the changes in baseline and end-of-trial values due to a minor variation in assessment time of pain severity after treatment.…”

A mini review of neuropharmacological effects of Rosa damascena Herrm.

“…47 In another clinical trial, ethanolic extract (400 mg capsules) of R. damascena had analgesic and anti-inflammatory effects and reduced postoperative pain. 48 The effects of R. damascena on pain relief have been presented in Table 5.…”