Effects of Topical Application and Oral Intake of Rosa damascena on Acute Pain in Adults: A Systematic Review and Meta-analysis

Abstract

Recent studies have reported conflicting results regarding the pain-alleviating effects of Rosa Damascena in topical and oral administration forms. Therefore, we evaluated the potential effects of topical application and oral intake of this herbal medicine on adults’ acute pain severity in a meta-analysis. A systematic search was performed on the Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science Core Collection, Embase, Cumulative Index to Nursing and Allied Health Literature, SID, and MagIran from inception to March 20, 2021. We included parallel-group and cross-over randomized controlled trials (RCTs) that compared the effects of any products of Rosa Damascena in oral and topical administration forms to placebo, non-treatment, or conventional treatment. Two independent researchers performed study screening and selection, data extraction, and risk of bias assessment. A random-effect model was used to pool the data. Of the 11 studies that met the inclusion criteria, four and seven administered Rosa damascena through topical application and oral intake, respectively. The oral intake of Rosa damascena reduced pain severity nonsignificantly ]standardized mean difference (SMD): -0.55; 95% confidence interval (CI): -1.27, 0.17; P= 0.132[. However, the topical application of this treatment had no painalleviating effect ]SMD: 0.10; 95% CI: -0.75, 0.96; P= 0.814[. Most studies (n= 6) had fair methodological quality, and one reported mild allergic rhinitis as an adverse effect of the treatment. Further robust RCTs are suggested to compare the effects of oral intake and topical application of Rosa damascena on the severity of different types of acute pain in adults.

Effects of aromatherapy with Rosa damascene and lavender on pain and anxiety of burn patients: A systematic review and meta‐analysis

“… 39 Results of one meta‐analysis study indicated that using the oral intake of RD decreased pain in adult patients with different painful problems; however, it was not statistically significant. 68 The topical form of RD also did not show a pain‐alleviating effect. Included studies in the current meta‐analysis only used RD in the form of inhalation and other forms, such as oral and topical, were not used for pain management.…”

“…One of the non‐pharmacological strategies to relieve the pain and anxiety of burn patients is aromatherapy with RD and lavender 39 . Results of one meta‐analysis study indicated that using the oral intake of RD decreased pain in adult patients with different painful problems; however, it was not statistically significant 68 . The topical form of RD also did not show a pain‐alleviating effect.…”

Effects of Inhalation Aromatherapy With Rosa damascena (Damask Rose) on the State Anxiety and Sleep Quality of Operating Room Personnel During the COVID-19 Pandemic: A Randomized Controlled Trial

“…Likewise, it was hypothesized that aromatherapy with damask rose can improve sleep quality by reducing anxiety 29 . Similarly, it seems that damask rose aromatherapy can alleviate sleep disorders by the reduction of pain severity, as two meta-analyses indicated the analgesic effects of this intervention and pain is a risk factor for sleep disorders 55,56 .…”

Rosa Damascena mill for treating adults' anxiety, depression, and stress: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…Although RDM have evaluated in the recent meta-analyses for painalleviating and sleep-enhancing properties (Ghorbani Rami et al, 2021;Koohpayeh, Hosseini, Nasiri, & Rezaei, 2021b;Nasiri et al, 2021), no systematic reviews or meta-analyses have ever summarized the antianxiety, antidepressant, and anti-stress potencies of this herbal medicine to the best of our knowledge. Since systematic to placebo or routine care.…”

“…In most countries, many medicinal herbs are used with inconsistent evidence to support their applications (Williamson, Liu, & Izzo, 2020). Although RDM have evaluated in the recent meta‐analyses for pain‐alleviating and sleep‐enhancing properties (Ghorbani Rami et al, 2021; Koohpayeh, Hosseini, Nasiri, & Rezaei, 2021b; Nasiri et al, 2021), no systematic reviews or meta‐analyses have ever summarized the antianxiety, antidepressant, and anti‐stress potencies of this herbal medicine to the best of our knowledge. Since systematic reviews and meta‐analyses are on top of the clinical evidence hierarchy (Izzo, Hoon‐Kim, Radhakrishnan, & Williamson, 2016), this review was conducted as the first of its kind to summarize the effects of RDM on treatment of anxiety, depression, and stress.…”