Evaluation of the effect of acupuncture on pain of patients with refractory trigeminal neuralgia

Lavaee, Fatemeh; Rafiee, Farideh; Tabassom, Zahra; Ranjbar, Zahra

doi:10.1007/s11726-021-1273-5

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…The attacks can occur repeatedly and last for a few seconds. The attacks may begin when the trigger zone is stimulated, which can be placed within the trigeminal nerve pathway (Lavaee et al, 2021; Love & Brain, 2001). TN has different etiologies, causing demyelination in the trigeminal zone.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population

Lavaee,

Didar,

Afshari

2023

Clinical & Exp Dental Res

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ObjectivesThe goal of this study is to measure and compare the hormonal serum levels (estrogen, progesterone, testosterone, prolactin, dihydrotestosterone [DHT]) in trigeminal neuroglia (TN) menopausal women and healthy women.Materials and MethodsThis cross‐sectional and case‐control study was performed in 2018 and 2019. For this study, menopausal women with confirmed TN were enrolled. Twenty‐two healthy women in the control group and 19 in the case group participated. Blood samples were taken from participants for assessment of hormonal serum levels (estrogen, progesterone, testosterone, prolactin, DHT). Data were analyzed by SPSS version 18. Mann−Whitney, T‐test, kormography test, nonmetric, χ2 test, and odds ratios have been used.ResultsIn patients with TN, the serum level of testosterone was significantly higher (p = .036), and the serum level of prolactin (p = .016) was significantly lower. Other evaluated hormones' serum level was identical in the two groups. Patients with abnormal estrogen levels were more in the TN group in comparison with the healthy group. The abnormality of progesterone in TN patients was more in comparison to the healthy control group.ConclusionsEstrogen and progesterone serum levels in TN patients are higher in comparison with the healthy group, while prolactin and testosterone serum levels are lower in the control group. Moreover, the DHE serum level is similar in both groups.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population

Lavaee,

Didar,

Afshari

2023

Clinical & Exp Dental Res

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Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial

Li,

Sun,

Luo

et al. 2024

J Neurol

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Background Trigeminal neuralgia (TN) is difficult to treat due to its severe pain intensity and recurring episodes, which significantly impact quality of life. Objectives We aimed to assess the effectiveness of electroacupuncture (EA) in alleviating the pain intensity in TN, and to determine whether EA combined with low-dosage carbamazepine (CBZ) has a synergistic effect. Methods A multi-centre, randomized, 2 × 2 factorial trial was conducted. Participants who met the inclusion criteria received active EA or sham EA for 60 min, three times a week for four weeks; CBZ (300 mg per day) or placebo for four weeks. The primary outcome was the change in visual analog scale (VAS) score from baseline to weeks 2, 4, 16, and 28. Secondary outcomes included quality of life and adverse events. Results A total of 120 participants (75 females and 45 males; mean (SD) age, 58.5 (15.3) years) were included. The main effects of EA and CBZ were significant (P < 0.001), and there was a significant interaction was identified between the interventions (P = 0.041). Participants who received EA (mean difference [MD], −0.3 [95% CI, −0.40 to −0.20] at week 2; −1.6 [−1.70 to −1.50] at week 4; −1.1 [−1.31 to −0.89] at week 16; −0.8 [−1.01 to −0.59] at week 28), CBZ (MD, −0.6 [95% CI, −0.70 to −0.50] at week 2; −0.9 [−1.03 to −0.77] at week 4, −0.2 [−0.41 to 0.01] at week 16, 0.2 [−0.01 to 0.41] at week 28), and the combination of both (MD, −1.8 [95% CI, −1.90 to −1.70] at week 2; −3.7 [−3.83 to −3.57] at week 4, −3.4 [−3.61 to −3.19] at week 16, −2.9 [−3.11 to −2.69] at week 28) had a greater reduction in VAS score over the treatment phase than their respective control groups (sham EA, placebo, and sham EA plus placebo). EA-related adverse events (6/59, 10.17%) were lower than that of CBZ (15/59, 25.42%) during the whole phases. Conclusions EA or CBZ alone are effective treatments for TN, while the combination of EA and low-dosage CBZ exerts a greater benefit. These findings in this trial demonstrate that the combination of EA and low-dosage CBZ may be clinically effective under certain circumstances. Trial registration NCT03580317.

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Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis

Ang

Kim

Heo

et al. 2023

Complementary Therapies in Clinical Practice

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Evaluation of the effect of acupuncture on pain of patients with refractory trigeminal neuralgia

Cited by 4 publications

References 24 publications

Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population

Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population

Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial

Acupuncture for the treatment of trigeminal neuralgia: A systematic review and meta-analysis

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