Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus following lower third molar removal: A randomized controlled clinical trial

Torul, Damla; Ömezli, Mehmet Melih; Kahveci, Kadircan

doi:10.1016/j.jormas.2020.02.004

Cited by 34 publications

(24 citation statements)

References 28 publications

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“…Similar result was also reported by Al-Hamed et al and Marenzi et al (19,20) . On the other hand, results of the current study is in disagreement with Torul et al and Gülşen et al , They found that PRF seem to have no positive effects pain after surgery (18,21) .…”

Section: Discussioncontrasting

confidence: 99%

“…Regarding postoperative edema, our result is in agreement with Muñoz et al using PRF in Combination with traditional bone grafts potentially accelerates wound healing and reduces post-surgical inflammation (16) . Similar result was also reported by Ozgul et al (17) .On the other hand, it is in controversy with Torul D who found that PRF seem to have no positive effects edema after third molar surgery (18) .…”

Section: Discussionsupporting

confidence: 77%

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Evaluation of Mineralized Plasmatic Matrix as a grafting material around immediate dental implant in mandibular posterior teeth

Mansour

Khalil

Shuman

2021

Al-Azhar Journal of Dental Science

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Objective: the present study was performed to evaluate Mineralized Plasmatic Matrix (MPM) as a grafting material around immediate dental implant in mandibular posterior teeth. Subjects and Methods: Eight patients were selected for immediate dental implant in mandibular posterior teeth and use MPM as a grafting material around the implant. After surgery each patient were evaluated clinically at the following interval immediate, one week, two weeks, and three months postoperatively for:: Presence of infection, Edema, Graft exposure and/or loss, Soft tissue dehiscence, Pain, Nerve injury and Implant stability, and radiographically immediate and three months postoperatively interval by CBCT for: Bone density around the dental implant and Horizontal bone loss around the dental implant. Results: All patients hadn't any infection, nerve injury, Graft exposure and /or loss, soft tissue dehiscence and facial edema throughout the study till three months. Osstel at 3 months (81.0±7.68) was higher than immediately (63.40±4.16). Bone density at 3 months (447.0± 28.64) was higher than immediately (243.0±17.18). Patients experienced mild to moderate pain after surgery, at the surgical sites which decrease gradually during four days postoperatively then disappeared completely at the 7 th day. Conclusion: The use of MPM with immediate implant reduces postoperative infection, edema, pain, graft exposure and/or loss and soft tissue dehiscence. Use of MPM with immediate implant enhances the implant stability, improves bone density around it and decrease marginal bone loss around the immediate implant.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 77%

Evaluation of Mineralized Plasmatic Matrix as a grafting material around immediate dental implant in mandibular posterior teeth

Mansour

Khalil

Shuman

2021

Al-Azhar Journal of Dental Science

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“…In a recent three-arm randomized trial on lower third molar surgery, Torul et al compared CGF, advanced PRF (A-PRF), and natural healing [44]. They evaluated VAS score, analgesics, edema, trismus in the first post-operative week, and found no significant benefits of CGF or A-PRF over control in any of the variables assessed.…”

Section: Discussionmentioning

confidence: 99%

Concentrated Growth Factors vs. Leukocyte-and-Platelet-Rich Fibrin for Enhancing Postextraction Socket Healing. A Longitudinal Comparative Study

et al. 2020

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Platelet concentrates (PCs) have been used for over 20 years in dentistry, as an adjunct to oral surgery procedures, to improve hard and soft tissue healing and control postoperative symptoms. Among various PCs, Leukocyte and Platelet-Rich Fibrin (L-PRF) has become very popular due to its excellent cost-effectiveness ratio, and to the simple preparation protocol, but comparative clinical studies with other PCs are lacking. The aim of this split-mouth cohort study was to evaluate the effect of Concentrated Growth Factors (CGF), a recently introduced PC, as compared to L-PRF for enhancing post-extraction socket healing. Methods: Patients in need of bilateral tooth extractions were included. Each side was treated with either CGF or L-PRF. Pain, socket closure and healing index were the main outcomes. Results: Forty-five patients (24 women), aged 60.52 ± 11.75 years (range 37–87 years) were treated. No significant difference in outcomes was found, except for Pain at day 1 (p < 0.001) and socket closure in the vestibulo-palatal/lingual dimension at day 7 post-extraction (p = 0.04), both in favor of CGF. Conclusions: based on the present results, CGF proved to be as effective and safe as L-PRF, representing a valid alternative option for improving alveolar socket healing and reducing postoperative discomfort.

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“…In some articles, there was an efficient control with PRF for the items pain, edema, trismus, and bone repair accelerator (Zahid & Nadershah, 2019;Yüce & Kömerik, 2019;Kapse et al, 2019;Daugela et al, 2018;Kumar et al, 2015). However, some studies reported no significant effect in controlling pain, edema, and postoperative trismos (Torul et al, 2020;Ritto et al, 2019;Asutay et al, 2017) although the acceleration of tissue repair in the region is evident. The study with the largest number of patients ( 75) is part of this list (Torul et al, 2020).…”

Section: Platelet-rich Fibrin/platelet Rich Plasmamentioning

confidence: 99%

“…However, some studies reported no significant effect in controlling pain, edema, and postoperative trismos (Torul et al, 2020;Ritto et al, 2019;Asutay et al, 2017) although the acceleration of tissue repair in the region is evident. The study with the largest number of patients ( 75) is part of this list (Torul et al, 2020). There is also a report of edema improvement with no effectiveness in reducing trismus and pain (Afat et al, 2018;Ozgul et al, 2015).…”

Section: Platelet-rich Fibrin/platelet Rich Plasmamentioning

confidence: 99%

Non-conventional therapies for analgesia

Pellizoni

Faccio

Jodas

et al. 2021

RSD

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Purpose: Third molar surgery is a quite common procedure. Some patients experience pain associated with this situation. The aim of this article aims to discuss non-conventional therapies for the management of postoperative pain associated with third molar surgery. Methods: An extensive literature search was conducted with the keywords “third molar” + “pain” and all articles that excluded already established drugs as analgesics, anti-inflammatories, or therapies such as laser therapy and ozone therapy whereas non-conventional drugs and therapies were retained. Results: The article rated bromelain, honey, hyaluronic acid, nicotine patches, Kinesio tape, TENS, anticonvulsants, curcumin, and melatonin. Some therapies are efficient and safe, while others have not shown promising results. Conclusions: Bromelain and Kinesio tape are considered the most effective non-conventional therapies for controlling postoperative pain, and even with few studies on them, they are therapies with promising results.

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Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus following lower third molar removal: A randomized controlled clinical trial

Cited by 34 publications

References 28 publications

Evaluation of Mineralized Plasmatic Matrix as a grafting material around immediate dental implant in mandibular posterior teeth

Evaluation of Mineralized Plasmatic Matrix as a grafting material around immediate dental implant in mandibular posterior teeth

Concentrated Growth Factors vs. Leukocyte-and-Platelet-Rich Fibrin for Enhancing Postextraction Socket Healing. A Longitudinal Comparative Study

Non-conventional therapies for analgesia

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