Evaluation of the Effects of High Intensity Interval Training on Cytokine Levels and Clinical Course in Treatment of Opioid Use Disorder

Dürmüş, Pelin Taş; Vardar, Erdal; Kaya, Oktay; Tayfur, Pınar; Süt, Necdet; Vardar, Selma Arzu

doi:10.5080/u25070

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Increased cortisol levels following exercise were associated with decreased substance craving. Significantly higher insulin-like growth factor1 (IGF-1) levels were also identified for participants in a HIIT group versus the control resulting in increased hippocampal BDNF expression and neuronal differentiation ( 22 ). HIIT provides greater benefits for physical and mental health compared to MIAE ( 23 , 24 ).…”

Section: Introductionmentioning

confidence: 99%

“…HIIT provides greater benefits for physical and mental health compared to MIAE ( 23 , 24 ). Furthermore, patients with SUDs have displayed significant improvements on depression, anxiety, and substance craving scales following a HIIT regimen compared to the control group ( 22 ). Other research has confirmed these findings and highlighted additional health benefits conferred by HIIT in those with SUDs such as decreased cardiovascular disease and premature death risk ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

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High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Tyler,

Podaras,

Richardson

et al. 2023

Front. Public Health

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BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and relapse prevention programs. However, we need to better understand different exercise regimens and determine which would be the most beneficial for SUDs. Recently, high intensity interval training (HIIT) has gained attention in comparison with aerobic and resistance exercise. Little is known regarding the neurobiological mechanisms of HIIT, including its effects on dopamine signaling and receptor levels in the brain. The present study examined the effects of chronic HIIT exercise on dopamine signaling as measured by dopamine type 1-like receptor (D1R)-like, dopamine type 2-like receptor (D2R)-like, and tyrosine hydroxylase (TH) quantification in the brains of male and female rats as measured by [3H] SCH 23390 and [3H] spiperone autoradiography, and TH-immunoreactive optical density values.MethodsRats were separated in two groups: sedentary and HIIT exercise. Exercise was on a treadmill for 30 min daily (10 3 min cycles) for six weeks with progressive speed increased up to 0.8 mph (21.5 m/min).ResultsResults showed for D2R-like binding, a significant effect across the ventral caudate putamen (V CPU) between sexes, such that mean D2R-like binding was 14% greater for males than females. In the nucleus accumbens shell (Nac Shell), the HIIT Exercise rats showed 16% greater D2R-like binding as compared to the sedentary rats. No significant effects of HIIT exercise were found across groups for brain D1R-like binding levels or TH expression.ConclusionThese results suggest that HIIT exercise can modulate dopamine signaling by way of increased D2R. These findings support the premise that HIIT exercise plays an important role in dopamine signaling and, may provide a potential mechanism for how HIIT exercise can impact the brain and behavior.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Tyler,

Podaras,

Richardson

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…The risk of bias assessment yielded 14 preselected studies, out of which four were excluded due to measuring of pain or craving symptoms rather than opioid misuse (Barry et al, 2012;Beitel et al, 2016;Taş Dürmüş et al, 2020;Uebelacker et al, 2019). Five out of the nine remaining preselected studies had consistent scoring among Reviewers 1 (WCG) and 2 (PPMM) and did not require the review of a third author (CC; see Table 3; Dunne et al, 2020;Ford et al, 2018;Goldsmith et al, 2020;Mehl-Madrona et al, 2016;Thorlund et al, 2021).…”

Section: Selection Of Studiesmentioning

confidence: 99%

The association between exercise and prescription opioid misuse: A scoping review.

Córdoba-Grueso,

Mattey-Mora,

Chen

et al. 2024

Experimental and Clinical Psychopharmacology

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Exercise prevents chronic diseases and modulates pain. People experiencing pain often use opioids for relief, increasing the risk of prescription opioid misuse. Nonetheless, exercise may influence prescription opioid misuse through the release of endorphins or induced injury-related pain. We aimed to summarize the existing literature on the association between exercise and prescription opioid misuse. We identified studies published through December 2021 in Cochrane, Embase, Medline, and Pubmed, using search terms like “opioid-related disorders,” “opioid misuse,” “exercise,” and “sports.” Observational and experimental studies with adult samples published in English were included. Exclusion criteria included participants <18 years old, studies including heroin use as the outcome, and studies conducted among pregnant or institutionalized individuals. The risk of bias and quality assessment were conducted independently by two authors using the National Institutes of Health Study Quality Assessment Tools, and decisions were cross-checked with a third author. Our search yielded 10,796 records, of which eight studies were included. These studies were heterogeneous clinically and methodologically. Three were intervention trials, three were cross-sectional, and two were cohort studies. Three studies evaluated yoga, two evaluated exercise, and three evaluated sports. Significant findings showed lower prescription opioid misuse among people who exercise, except for one study that showed greater odds of prescription opioid misuse among college athletes. We conclude that the findings on the association between exercise and prescription opioid misuse vary, even within similar study types and samples. Future researchers should consider large samples, standardized questions, and common outcome measures in research on exercise and prescription opioid misuse.

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“…In individuals suffering from alcohol use disorders, physical activity promoted psychological well-being by improving their emotions, enhancing self-efficacy, and reducing the risk of depression (Sari et al, 2019). The inclusion of physical exercise in the treatment of opioid use disorder significantly reduces depression and anxiety (Durmus et al, 2020). Zhu et al (2018) suggested that long-term Tai Chi exercise has a positive impact on depression and overall health in amphetamine-type stimulant use disorder (ATS) patients.…”

Section: Introductionmentioning

confidence: 99%

Effect of physical exercise on the emotional and cognitive levels of patients with substance use disorder: a meta-analysis

Zheng,

Zhao,

Chen

et al. 2024

Front. Psychol.

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IntroductionThis study investigated the impact of different modes of physical exercise on the emotional and cognitive levels of patients with Substance Use Disorder (SUD). By exploring the most effective intervention types, cycle, frequency, and duration, we aimed to provide evidence-based recommendations for the adjunctive treatment of SUD.MethodsWe conducted a systematic search in five databases, including PubMed, Web of Science, The Cochrane Library, ScienceDirect, and EBSCO, from database inception up to May 2023, and identified 4,255 randomized controlled trials addressing the influence of physical exercise on the emotional and cognitive levels of SUD patients. Data extraction and analysis were performed using Review Manager 5.4 software, focusing on 11 studies that met the inclusion criteria and included 895 participants. Subsequently, a meta-analysis was conducted using Stata 16.0 software, presenting the results in the form of standardized mean differences (SMD) and 95% confidence intervals (CI).ResultsOur findings indicate that physical exercise significantly alleviates anxiety and depression in SUD patients while improving their cognitive function. Specifically, physical exercise was found to reduce anxiety (SMD = −0.726 [−1.349, −0.103], p < 0.05) and depression (SMD = −0.666 [−1.077, −0.255], p < 0.05) and enhance cognitive levels (SMD = −0.523 [−0.887, −0.159], p < 0.05) among patients. Subgroup analysis further revealed that SUD patients benefitted most from physical exercise when engaging in aerobic exercises lasting over 12 weeks, with a frequency exceeding 40 sessions and each session lasting more than 60 min.DiscussionIn conclusion, our study affirms that physical exercise mitigates anxiety and depression while enhancing cognitive function in SUD patients, making it an effective measure for adjunctive clinical treatment.

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Evaluation of the Effects of High Intensity Interval Training on Cytokine Levels and Clinical Course in Treatment of Opioid Use Disorder

Cited by 5 publications

References 11 publications

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

The association between exercise and prescription opioid misuse: A scoping review.

Effect of physical exercise on the emotional and cognitive levels of patients with substance use disorder: a meta-analysis

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