Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction—A prospective, randomized, double-blind, placebo-controlled clinical trial

Kamenov, Zdravko; Fileva, Svetlana; Kalinov, Krassimir; Jannini, Emmanuele A.

doi:10.1016/j.maturitas.2017.01.011

Cited by 77 publications

(48 citation statements)

References 11 publications

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“…Ischemia and reperfusion have been reported to induce inflammatory reactions (28). Inflammatory reactions are characterized by the expression of local inflammatory cytokines, including TNF-α and IL-1β, the release of chemotactic factors and upregulation of cell adhesion molecules (29). The results of the present study revealed that miR-132 overexpression significantly reduced OGD-induced TNF-α, IL-1β, IL-6 and IL-8 levels in OGD-injured PC12 cells.…”

Section: Discussionsupporting

confidence: 49%

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MicroRNA-132 modifies angiogenesis in patients with ischemic cerebrovascular disease by suppressing the NF‑κB and VEGF pathway

Che

Zhang

et al. 2017

Mol Med Report

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In the present study, the expression of microRNA (miR)‑132 and the mechanism by which it modifies angiogenesis in patients with ischemic cerebrovascular disease (ICD) was investigated. RNA isolation and reverse transcription‑quantitative polymerase chain reaction were used to measure miR‑132 expression in patients with ICD. Inflammatory factors were measured using ELISA kits and western blotting measured B‑cell lymphoma‑2 (Bcl‑2)‑associated X/Bcl‑2 ratio (Bax/Bcl‑2 ratio), nuclear factor (NF)‑κB p65, matrix metalloproteinase‑9 (MMP‑9), vascular cell adhesion molecule‑1 (VCAM‑1) and protein expression of inducible nitric oxide synthase (iNOS), and vascular endothelial growth factor (VEGF) protein expression. miR‑132 expression in patients with ICD was lower compared with healthy volunteers. PC12 cells were used to create an oxygen glucose deprivation (OGD) model. miR‑132 overexpression in an in vitro model was able to reduce tumor necrosis factor‑a, interleukin (IL)‑1β, IL‑6, IL‑8, cyclooxygenase‑2, caspase‑3 and caspase‑9 levels, suppress Bax/Bcl‑2 ratio, NF‑κB p65, MMP‑9, VCAM‑1, iNOS, VEGF protein expression. The results suggested that miR‑132 may modify angiogenesis in patients with ICD by suppressing the NF‑κB pathway and promoting the VEGF pathway, and may develop into a therapy for ICD in future research.

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Section: Discussionsupporting

confidence: 49%

“…NF-κB is involved in body defense functions and inflammatory response-associated gene expression. It is an important transcription factor that binds to the promoters of inflammatory genes, including TNF-α, Cox-2, IL-1β, IL-6, IL-8, VCAM-1 and iNOS (29). NF-κB is bound to inhibiting factors in its inactive state (36).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-132 modifies angiogenesis in patients with ischemic cerebrovascular disease by suppressing the NF‑κB and VEGF pathway

Che

Zhang

et al. 2017

Mol Med Report

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“…After 8 weeks of treatment, our patients reported improvements by 5% of walked distance, so far. After correction for confounding factors, that is, age, cigarette smoking, and drugs use, this improvement persisted, suggesting a possible synergism between arginine/citrulline and TT in stimulating GH/IGF1 axis and testosterone production, respectively (Kamenov, Fileva, Kalinov, & Jannini, ).…”

Section: Resultsmentioning

confidence: 99%

Effects of nutraceuticals on sexual satisfaction and lower urinary tract symptoms in a cohort of young–old men

Perri

Ilacqua

Valenti

et al. 2017

Phytotherapy Research

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The aim of this study was to evaluate the effects of nutraceuticals containing multiple supplemental facts (Virherbe®/Rekupros®) on sexual satisfaction and lower urinary tract symptoms (LUTS) in young-old men. In an open-label trial, 40 males (mean age 66 ± 13) with sexual disturbances and mild LUTS but without cognitive/motor impairment and clinical hypogonadism were enrolled. Sexual desire (SD; IIEF-SD domain) and satisfaction (Global Assessment Question; GAQ), the capacity to perform daily activities (evaluated by 6-min walking test [6MWT]), and International Prostate Symptoms Scores (IPSS) were evaluated before and after oral administration of 2 capsules/day of each supplement for 8 weeks. The difference from baseline for SD was +2.6 (p < .05) and -4.2 points for IPSS (p < .05), with significance in subscales of urinary streaming/nocturia (p < .01), respectively; 6MWT increased from 507 ± 44 versus 527 ± 58 meters (p < .001). GAQ scale-responses showed overall improvement in overall 75% population, with a significant improvement in QoL (p < .01). These changes returned to baseline at 1-month withdrawal follow-up. No adverse events were reported. These supplemental facts improved sexual desire, satisfaction with sex life, physical performance, and LUTS in young-old men, suggesting that they may be effective in patients in whom standard treatments are not suitable.

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“…Tribestan is recommended for treatment of some infertility cases in men and women, for male impotence, for the relief of neurovegetative and neuropsychic symptoms in women with climacteric and post-castration syndrome, and for improving lipid metabolism. 123 For a period of 12 weeks, Kamenov et al 120 tested men with erectile dysfunction and hypoactive sexuality and reported similar results. Tribestan improved sexual function, and the treatment was easy and safe for patients.…”

Section: Sexual Problems Impotence and Hormonal Disbalancementioning

confidence: 91%

Chemical Constituents, Biological Properties, and Uses of Tribulus terrestris: A Review

Semerdjieva

Zheljazkov

2019

Natural Product Communications

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Tribulus terrestris L. (TT) (puncturevine) is a common weed that grows in many countries worldwide and in some places is considered as a noxious weed. The plant has been used in traditional Chinese and Indian medicines and is now considered as one of the most popular aphrodisiacs. It is known for its healing properties for sexual difficulties, impotence, and human and animal hormonal imbalance. It is also used as a sexual booster. Because of the plant’s active substances that can be used for curing sexual and other disorders, interest in it is increasing, and it is currently one of the most studied medicinal plants. The products and preparations manufactured from the aboveground plant parts are especially popular among athletes and people with health issues and diseases such as hormonal imbalance, sexual problems, heart problems, and various kidney and skin diseases. The aim of this review is a comprehensive and critical assessment of the scientific publications involving TT, with special reference to its chemical constituents and biological properties that may facilitate current understanding and future studies of this fascinating plant species. The objectives of this review were (1) to find knowledge gaps, (2) to discuss critically relevant publications and issues with materials and methods that may be prerequisites for contradictory results, and (3) to identify research and development areas. It was found that some of the studies on TT extracts as aphrodisiacs are controversial. A significant number of research publications claim that TT extracts and nutritional supplements containing TT improve muscle tone, have a common biostimulating effect, and improve spermogenesis. However, there are a growing number of publications that dispute these claims, as there are no empirical data on commonly accepted mechanisms of action. The main biologically active substances in TT are steroidal saponins, flavonoids, alkaloids, and lignan amides, the most studied being the steroidal saponins. Multiyear data on the metabolic profile of the species are generally lacking. There are a variety of methods used for extracting plant material, differences in methodologies and saponin analyses, and scientific instruments that were used. Lack of common standards could be a reason for differences in the pharmacological activity and composition of the TT preparations. Development of standard procedures and methods for collection of plant material and analyses are recommended. Selection and breeding efforts and agronomic studies of promising clones of TT would need to be conducted in order to develop TT as a new crop. This will provide consistency of supply and quality of the feedstock for the pharmaceutical industry and could provide a new cash crop for growers.

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Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction—A prospective, randomized, double-blind, placebo-controlled clinical trial

Cited by 77 publications

References 11 publications

MicroRNA-132 modifies angiogenesis in patients with ischemic cerebrovascular disease by suppressing the NF‑κB and VEGF pathway

MicroRNA-132 modifies angiogenesis in patients with ischemic cerebrovascular disease by suppressing the NF‑κB and VEGF pathway

Effects of nutraceuticals on sexual satisfaction and lower urinary tract symptoms in a cohort of young–old men

Chemical Constituents, Biological Properties, and Uses of Tribulus terrestris: A Review

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