Evaluation of the efficacy of 2-hydroxy-4-methylselenobutanoic acid on growth performance and tissue selenium retention in growing pigs1

Abstract

The aim of this study was to compare the efficacy of a new organic Se (2-hydroxy-4-methylselenobutanoic acid [HMSeBA]) source (SO) with sodium selenite (SS) and selenized yeast (SY) at various dietary levels for growth performance and tissue Se deposition in growing pigs. A total of 112 crossbred (Pietrain × [Large White × Landrace]) gilts were allotted at an average body weight of 26.73 kg to 7 dietary treatments with 8 replicate pens of 2 pigs per pen. Pigs were fed basal diets unsupplemented or supplemented either with SS, SY, or SO each at 0.1 or 0.3 mg Se/kg of diet for 32 d. Feed intake and BW were recorded during the experimental period. At the end of the experiment, blood, liver, and psoas major muscle of all gilts were collected for total Se and relative bioavailability determination. No differences were observed on final BW, ADG, ADFI, and G:F among dietary treatments. All Se-supplemented groups exhibited greater total Se contents in plasma (P < 0.01) and liver (P < 0.01) compared with unsupplemented control group. However, Se retention in psoas major muscle was improved only when organic Se source (SY or SO) was added to diets (P < 0.01). Regardless the Se level, the Se deposition in muscle was greater (P < 0.01) in pigs supplemented with SO than those supplemented with SY. Slope ratio assay confirmed the greater bioavailability of Se from organic compared with inorganic Se and also revealed that the relative bioavailability of Se from HMSeBA for plasma, liver, and muscle Se response was 170, 141, and 162%, respectively, for SY. This study shows a potential advantage of HMSeBA supplementation in the increase of Se contents in pig tissues, indicating that this new organic Se source could be an alternative source of Se in swine nutrition.

Effects of source on bioavailability of selenium, antioxidant status, and performance in lactating dairy cows during oxidative stress-inducing conditions

“…Previous ruminant reports have similarly demonstrated that Se organic sources outperformed SS in terms of bioavailability at different ages and physiological status (Weiss, 2003;Ceballos et al, 2009). In this regard, HMSeBA supplementation increases eggs and muscle Se enrichment in poultry (Briens et al, 2013;Jlali et al, 2013) and pigs (Jlali et al, 2014). Organic Se supplementation ameliorated the HSinduced imbalances in the oxidant and antioxidant systems.…”

“…However, when feedstuffs are Se deficient or Se requirements are transiently increased, supplemental Se (even at the maximum regulatory allowance) might be insufficient. Utilizing organic minerals is a feasible strategy to improve their bioavailability, as feeding HMSeBA improved Se concentration in blood and milk in lactating dairy cows (Sun et al, 2017) and has been shown to enrich other tissues in different species (Briens et al, 2013;Jlali et al, 2013;Jlali et al, 2014). Thus, we hypothesized the beneficial effects of HMSeBA could be further enhanced during an oxidative stress inducing condition, such as HS (Aréchiga et al, 1994).…”

“…Since its approval by the European Commission as a feed additive in 2013 (EFSA, 2013a), results from poultry (broilers and laying hens) have shown its efficacy at muscle and egg Se enrichment (Briens et al, 2013;Jlali et al, 2013). Similarly, HMSeBA supplementation increased tissue Se deposition in growing pigs (Jlali et al, 2014). In dairy cows, a previous study from our laboratory (utilizing a nonstressed model) confirmed that HMSeBA increases antioxidant capacity parameters in blood and Se concentration in plasma and milk when compared with SS supplementation (Sun et al, 2017).…”

The influence of selenium and selenoproteins on immune responses of poultry and pigs

“…In addition, other minor organic forms derived from plants or yeast metabolisms such as methylselenol, selenohomocysteine, and selenoadiosine have been reported due to the progress in analytical methodology of analysing Se-species (Bierla et al, 2012). More recently, a feed additive as, hydroxy-selenomethionine, (2-hydroxy-4-metylselenobutanoic acid or HMSeBA) was indicated to be more bioavailable than selenite and Se-yeast in monogastrics (Briens et al, 2013;Jlali et al, 2014;Zhao et al, 2017Zhao et al, , 2014.…”

“…A more recent study showed that greater Se accumulation in both natal and foetal tissues was associated with organic Se . In addition, the organic Se source hydroxy-selenomethionine, (2-hydroxy-4methylselenobutanoic acid or HMSeBA) when supplementated to growing pigs showed a higher deposition of Se in muscle compared to selenized yeast (Jlali et al, 2014). Likewise, in laying hens, the provision of HMSeBA increased Se deposition in eggs and breast muscle compared with other Se sources (sodium selenite and selenized yeast) (Jlali et al, 2013).…”