Evaluation of the efficacy of 99mTc-labeled ascorbic acid on common cold–cough drugs in rats

Abstract

Multiple-drug therapy is common in current clinical practice. Because of this, people have been ready to embrace simplistic approaches to cold treatment, such as vitamin C and zinc. Ascorbic acid (vitamin C) is mostly administrated together with cough-cold drugs. The aim of this study was to investigate the effect of cough-cold drugs on the uptake of ascorbic acid using 99m Tc-ascorbic acid ( 99m Tc-AA) in male albino Wistar rats. Ascorbic acid was labeled with Tc-99m and the distribution of 99m Tc-AA was investigated. The uptake of 99m Tc-AA was evaluated when administrated alone (group I), with chlorpheniramine maleate (CPR) (group II), with phenylpropanolamine hydrochloride (PPA) (group III), and with acetaminophen (APAP) (group IV). In some organs (apart from kidneys, intestinal system, and stomach) the uptake of 99m Tc-AA was not significantly affected by the administration of 99m Tc with CPR or 99m Tc with APAP at 120 min. On the other hand, there was significant difference in the uptake of 99m Tc-AA between groups I and III. The administration of 99m Tc-AA with PPA in rats caused an increase of the uptake of 99m Tc-AA at 120 min in the investigated organs compared to the administration of 99m Tc-AA alone. The present data show that vitamin C might be more effective for the treatment of common cold when coadministered with PPA compared to with CPR, with APAP, or alone.