Evaluation of the Expression of HER2 and c-KIT Proteins as Prognostic Markers in Superficial Bladder Urothelial Carcinoma

Hassan, Wael Abdo; Shalaby, Essam; Abo-Hashesh, Mona; Ali, Rehab Ibrahim

doi:10.2147/rru.s296974

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…In our study Her2/neu was expressed in 43.3 % of our studied cases with a significant link with tumor grade and size. Near results were reported by Abdou Hassan et al [28] in their study who observed HER2 expressions in 49% of their studied cases of NMIBC. Her2/neu was positively expressed with a significant association with concomitant carcinoma in situ and smokers in our study.…”

Section: Clinical and Pathological Characters Among Studied Nmibc Pat...mentioning

confidence: 57%

Prognostic role of CHEK2, FASN and Her2/neu Expression in Stage Ta-T1 Non-Muscle-Invasive Bladder Cancer (NMIBC)

Elaidy¹,

Abdelbary²,

Qasem³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Though linked with a favorable overall survival rate, the heterogeneity of NMIBC (non-muscle invasive bladder cancer) has an effect on patients' rates of recurrence. The decision making is depended on the established pathological and clinical parameters for each individual. Therefore, to improve clinical outcome, life quality and survival rates of oncological patients, more parameters are needed to support the decision.Objectives: Analysis the prognostic potential of CHEK2, FASN and Her2/neu immunohistochemical expression in fifty cases of non-muscle invasive bladder cancer who underwent TURBT as well as adjuvant intravesical BCG with a focus on prognostication of recurrence as well as progression among NMIBC. Materials and Methods: Our study included fifty cases who had primary papillary superficial (noninvasive) TCC " transitional cell carcinoma"(Stage Ta-T1; with or without CIS of the bladder. Only the tumors containing proper detrusor muscle in biopsy were involved in this study. Between January 2016 and December 2019, the Urology department performed surgical resection. Results: Decrease or loss of CHE2 expression was reported among (56%) of the patients, which was significantly linked with tumor size, smoking, grade, multifocality and concomitant Cis. High FASN expression was demonstrated among (68%) NMIBC cases, expression was significantly linked with tumor size, smoking, grade, multifocality as well concomitant Cis. Positive Her2/neu was found in of (42%) the cases, and the expression was significantly linked with tumor size, smoking, grade, multifocality and concomitant carcinoma in situ. The overall disease-free survival was significantly correlated with low expression of CHEK2 and positive Her2neu. Conclusion: Loss of CHEK2, high FASN and positive Her2/neu in the biopsies of noninvasive ''superficial'' urothelial carcinomas is an independent predictor of tumor progression.

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Section: Clinical and Pathological Characters Among Studied Nmibc Pat...mentioning

confidence: 57%

Prognostic role of CHEK2, FASN and Her2/neu Expression in Stage Ta-T1 Non-Muscle-Invasive Bladder Cancer (NMIBC)

Elaidy¹,

Abdelbary²,

Qasem³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…Bladder cancer (BCa) is one of the most common malignancies, and it counts for about 165,000 deaths/year worldwide [1][2][3]. Overall, 75% of newly diagnosed BCas are non-muscle-invasive (NMIBC), which is a disease burdened by recurrence in more than 60% of cases and progression in more than 10% [4,5].…”

Section: Introductionmentioning

confidence: 99%

Intravesical Therapy for Non-Muscle-Invasive Bladder Cancer: What Is the Real Impact of Squamous Cell Carcinoma Variant on Oncological Outcomes?

et al. 2022

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Background and Objectives: To evaluate the oncological impact of squamous cell carcinoma (SCC) variant in patients submitted to intravesical therapy for non-muscle-invasive bladder cancer (NMIBC). Materials and Methods: Between January 2015 and January 2020, patients with conventional urothelial NMIBC (TCC) or urothelial NMIBC with SCC variant (TCC + SCC) and submitted to adjuvant intravesical therapies were collected. Kaplan–Meier analyses targeted disease recurrence and progression. Uni- and multivariable Cox regression analyses were used to test the role of SCC on disease recurrence and/or progression. Results: A total of 32 patients out of 353 had SCC at diagnosis. Recurrence was observed in 42% of TCC and 44% of TCC + SCC patients (p = 0.88), while progression was observed in 12% of both TCC and TCC + SCC patients (p = 0.78). At multivariable Cox regression analyses, the presence of SCC variant was not associated with higher rates of neither recurrence (p = 0.663) nor progression (p = 0.582). Conclusions: We presented data from the largest series on patients with TCC and concomitant SCC histological variant managed with intravesical therapy (BCG or MMC). No significant differences were found in term of recurrence and progression between TCC and TCC + SCC. Despite the limited sample size, this study paves the way for a possible implementation of the use of intravesical BCG and MMC in NMIBC with histological variants.

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“…Moreover, NMIUC progresses to MIUC in approximately 43% of patients [ 6 ]. Thus, despite advancements in the management of bladder carcinomas, the outcomes have remained largely unchanged over several decades [ 7 ], highlighting the need to identify additional pathological parameters and biomarkers that could affect carcinogenesis and help improve management procedures [ 8 ].…”

mentioning

confidence: 99%

Significance of tumor-associated neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinoma

Hassan

ElBanna

Noufal

et al. 2023

JPTM

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Background: Tumor-infiltrating neutrophils and lymphocytes play essential roles in promoting or combating various neoplasms. This study aimed to investigate the association between tumor-infiltrating neutrophils and lymphocytes and the neutrophil-to-lymphocyte ratio in the progression of urothelial carcinoma. Methods: A total of 106 patients diagnosed with urothelial carcinoma were was. Pathological examination for tumor grade and stage and for tumor-infiltrating neutrophils, both CD4 and CD8+ T lymphocytes, as well as the neutrophil- to-lymphocyte ratio were evaluated. Results: The presence of neutrophils and the neutrophil-to-lymphocyte ratio correlated with high-grade urothelial neoplasms. In both low- and high-grade tumors, the lymphocytes increased during progression from a non-invasive neoplasm to an early-invasive neoplasm. CD8+ T lymphocytes increased in low-grade non–muscle-invasive tumors compared to non-invasive tumors. Additionally, there was a significant decrease in CD8+ T lymphocytes during progression to muscle-invasive tumors. Conclusions: Our results suggest that tumor-infiltrating neutrophils and CD8+ T lymphocytes have a significant effect on tumor grade and progression.

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Evaluation of the Expression of HER2 and c-KIT Proteins as Prognostic Markers in Superficial Bladder Urothelial Carcinoma

Cited by 3 publications

References 26 publications

Prognostic role of CHEK2, FASN and Her2/neu Expression in Stage Ta-T1 Non-Muscle-Invasive Bladder Cancer (NMIBC)

Prognostic role of CHEK2, FASN and Her2/neu Expression in Stage Ta-T1 Non-Muscle-Invasive Bladder Cancer (NMIBC)

Intravesical Therapy for Non-Muscle-Invasive Bladder Cancer: What Is the Real Impact of Squamous Cell Carcinoma Variant on Oncological Outcomes?

Significance of tumor-associated neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinoma

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