Evaluation of the Groningen Frailty Indicator and the G8 questionnaire as screening tools for frailty in older patients with cancer

Baitar, Abdelbari; Fraeyenhove, Frank Van; Vandebroek, A.; Droogh, E. De; Galdermans, D.; Mebis, Jeroen; Schrijvers, Dirk

doi:10.1016/j.jgo.2012.08.001

Cited by 117 publications

(98 citation statements)

References 31 publications

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“…The baseline characteristics of the remaining 63 patients are displayed in Table 1 and results of the GFI in Supplementary Table 2. Median age of included patients was 75 years (range 66-92) and 35% were women; 65% of patients were married, 27% was widower and 8% was unmarried. Median Charlson comorbidity index was 1 (range 0-6) and patients used a median of eight types of prescription medications (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Median eGFR at inclusion was 16 mL/min (range 5-34).…”

Section: Resultsmentioning

confidence: 99%

“…13,14 In geriatric oncology, several frailty screening tools are used to help identifying vulnerable patients, 15 including the GFI. 16,17 As patients with advanced renal failure experience a symptom burden and impairment of quality of life similar to that of patients with terminal malignancy, such tools could perhaps also be used to screen for potentially frail elderly among geriatric ESRD patients. 18 In this study, we aimed to assess whether the GFI can be used to distinguish fit older ESRD patients, likely able to tolerate and benefit from dialysis, from frail older patients who need further evaluation with a geriatrician's comprehensive assessment in a daily nephrology outpatient setting.…”

Section: Introductionmentioning

confidence: 99%

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Groningen frailty indicator in older patients with end-stage renal disease

et al. 2015

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Background: Currently over 55% of end-stage renal disease (ESRD) patients are aged 60 years and patients 475 years represent the fastest growing segment of the dialysis population. We aimed to assess whether the Groningen frailty indicator (GFI) can be used to distinguish fit older ESRD patients, likely able to tolerate and benefit from dialysis, from frail older patients who need further evaluation with a geriatrician's comprehensive assessment. Methods: All patients aged 65 years visiting the pre-dialysis unit at the Gelre hospital between 2007 and 2013 were included and underwent the GFI (n ¼ 65). Patients with GFI 4 (frail) were referred for geriatric consultation (n ¼ 13). Results of the GFI and nephrologists' evaluation were compared with geriatrician's assessment. Survival rates and outcomes after one year of follow up were recorded. Results: Twenty patients (32%) were identified as frail. Of the problems identified by the geriatrician in 13 patients, 55% were not reported in the nephrologists' notes. The first year after inclusion, 30% of patients with a GFI 4 died, compared to 9% of fit patients (p ¼ 0.04). Moreover, 90% of frail patients had been hospitalized one or more times, compared to 53% in the fit group (p ¼ 0.005). Conclusion: Although the GFI can be a useful instrument to identify ESRD patients at risk, both the GFI and the nephrologists' assessment failed to identify specific geriatric impairments. Further research is needed to develop a specific frailty indicator for ESRD patients and to determine the value and effect of a comprehensive geriatric assessment in ESRD patients.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Groningen frailty indicator in older patients with end-stage renal disease

et al. 2015

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“…There is no consensus on the type, measurement, and cut-off of specific domains to be included in a GA [29,30,31]. Most studies aiming to conduct a GA differ in the actual construct being measured [9].…”

Section: Methodsmentioning

confidence: 99%

“…If no such score was available (polypharmacy, falls, diagnosis of cognitive impairment such as dementia), a positive record in the patient's file was set as identifying a dimension as being frail. There is no consensus on how many dimensions of a GA should be impaired for classifying a patient as frail; studies use several different criteria [29,30,31]. Frailty was defined as 2 or more of the dimensions included in our GA being identified as ‘impaired' [9], in order to specify a cut-off value to prevent patients being casually classified as frail and to avoid ceiling effects.…”

Section: Methodsmentioning

confidence: 99%

A Questionnaire Study to Assess the Value of the Vulnerable Elders Survey, G8, and Predictors of Toxicity as Screening Tools for Frailty and Toxicity in Geriatric Cancer Patients

et al. 2016

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Background: The aim of this study was to identify an appropriate screening instrument for the identification of frail elderly patients in a tertiary cancer center. In order to improve cancer care for older patients, the use of a geriatric assessment (GA) has been proposed to identify frail patients or those who are at a higher risk for chemotherapy-related toxicities. In busy clinical routine, an appropriate screening instrument could be used to spare time- and resource-consuming application of GA. Patients and Methods: We administered the Vulnerable Elders Survey (VES-13), G8 questionnaire, and Predictors of Toxicity (POT) as well as a GA at the first visit of 84 consecutive patients at a single Comprehensive Cancer Center. Analysis for patients' characteristics as well as sensitivity, specificity, and positive and negative predictive value (npv) was conducted. Results: The median age of the patients was 73 years (range 63-93 years), 61.9% were male, most (63%) suffered from gastrointestinal tumors, 39.3% had a multiple cancer diagnosis, and 53.6% had metastasis. 30 (35.7%) individuals were classified as ‘frail' by the GA. Sensitivity of G8 was 38.3%, and the npv was 63.8%. Sensitivity for VES-13 was 57.1%, and npv was 76.3%. Sensitivity of POT was 72.7%, and the npv was 80.6%. Conclusion: For the first time, the VES-13, G8, and POT are compared in a sample of older German patients. The POT seems to be a sufficient screening tool to identify frail patients in a tertiary referral cancer center and helps to save time and resources compared with a complete GA.

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“…However, given the busy clinical environment, it is practically difficult and time consuming to evaluate all CGA items. Therefore, diverse CGA-related screening methods focusing on ease of applicability and aiming to accurately assess frailty (e.g., Vulnerable Elders Survey-13 [VES-13], Geriatric 8 [G8], and Groningen Frailty Index [GFI]) have been introduced and their predictive values have been reviewed [4,5].…”

Section: Introductionmentioning

confidence: 99%

An Introduction to a Head and Neck Cancer-Specific Frailty Index and Its Clinical Implications in Elderly Patients: A Prospective Observational Study Focusing on Respiratory and Swallowing Functions

et al. 2016

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Introduction. Frailty refers to a decreased physiologic reserve in geriatric patients and its importance in terms of treatment planning and outcome prediction has been emphasized in oncologic practices for older patients with cancer. We investigated the clinical implications of a head and neck cancer (HNC)-specific frailty index suggested by prospective clinical and functional evaluations of HNC patients. Materials and Methods. We analyzed data on 165 elderly patients with HNC who were prospectively enrolled in our hospital from 2010 to 2013. Pretreatment functional evaluations were performed according to all comprehensive geriatric assessment (CGA) domains. We additionally evaluated the patients' respiratory and swallowing functions using pulmonary function tests, voice handicap index (VHI), MD Anderson Dysphagia Inventory (MDADI), and other associated tests. Factors affecting the 2-year morbidity and mortality were also analyzed.

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Evaluation of the Groningen Frailty Indicator and the G8 questionnaire as screening tools for frailty in older patients with cancer

Cited by 117 publications

References 31 publications

Groningen frailty indicator in older patients with end-stage renal disease

Groningen frailty indicator in older patients with end-stage renal disease

A Questionnaire Study to Assess the Value of the Vulnerable Elders Survey, G8, and Predictors of Toxicity as Screening Tools for Frailty and Toxicity in Geriatric Cancer Patients

An Introduction to a Head and Neck Cancer-Specific Frailty Index and Its Clinical Implications in Elderly Patients: A Prospective Observational Study Focusing on Respiratory and Swallowing Functions

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