Evaluation of the Haematinic Activities of Extracts of Justicia secunda Vahl Leaves in Red Blood Cells of Laboratory Rats

Yamoah, Ahimsa; Adosraku, Reimmel Kwame; Amenu, Justice D; Baah, Michael Kwesi; Abaye, Daniel A

doi:10.37247/pabsc.1.2020.19

Cited by 6 publications

(9 citation statements)

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“…Administration of phenylhydrazine caused a moderate and significant drop in hemoglobin, red blood cell count and hematocrit. The results obtained are similar to those of Ryu and Yook [35] and Yamoah et al [29] who observed a decrease in these hematological parameters of 50% and 55% respectively, with an administration of 40 mg/kg/d of phenylhydrazine in Sprague Drawley rats.…”

Section: Discussionsupporting

confidence: 90%

“…It should therefore be noted that the most common chemical groups in coloring plants traditionally used for their anti-anaemic effects are polyphenols (tannins, anthocyanins, flavonoids), alkaloids, reducing compounds and saponosides. These results are comparable to those obtained by Kambou et al [25] to those of Yamoah et al [29], and Gbénou et al [30] who also noted the presence of these chemical groups in J. secunda plant and spirulina algae extracts tested for their anti-anaemic activity.…”

Section: Phytochemical Screeningsupporting

confidence: 91%

“…These results are comparable to those of Gbénou et al [30] who proved extracts of J. secunda lead to resorption of up to 100.28% on day D15 of treatment. They are also close to those Yamoah et al [29] on the quite remarkable resorption power of Justicia secunda against anemia.…”

Section: Evolution Of the Red Blood Cell Countsupporting

confidence: 91%

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Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa and Justicia secunda

Fagbohoun¹,

Nonvidé²,

Orou³

et al. 2022

AJPS

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Justicia secunda, Sorghum bicolor, Gossypiun barbadense and Hibiscus sabdariffa are dye plants traditionally used in Benin for the treatment of anemia. This work is part of the therapeutic valorization of dyes from these plants. Its objective is to characterize their composition in chemical groups and evaluate their harmlessness and their anti-anaemic property in laboratory rats. Anemia was induced in Wistar rats by phenylhydrazine hydrochloride followed by treatment by gavage with hydroethanolic extracts of the plants studied. Phytochemical screening of these extracts made it possible to characterize the major chemical groups, in particular alkaloids, polyphenols including tannins, flavonoids and leucoanthocyanins, as well as reducing compounds and saponosides in the plants studied. Cytotoxic analysis of these extracts on Artemia salina shrimp larvae revealed globally high LC 50 values of between 3.14 and 4.64 mg/mL, which testify a priori to the harmlessness of these extracts. The administration of the hydroethanolic extract of each plant to anaemic rats at doses of 2000 mg/kg/d promoted, after 15 days, an increase in hemoglobin levels, the number of red blood cells and hematocrit, going to more than 90% recovery of the hematological parameters involved. The highest rate, 99.06% being that of the species Justicia secunda followed closely by Sorghum

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Section: Discussionsupporting

confidence: 90%

Section: Phytochemical Screeningsupporting

confidence: 91%

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Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa and Justicia secunda

Fagbohoun¹,

Nonvidé²,

Orou³

et al. 2022

AJPS

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“…[8] 2.5. Animal treatment and experimental design: [9,10] A total of 30 albino rats were used for this experiment. Six rats were kept as normal control group (Group 1), while 24 rats were made anemic by oral administration of Phenylhydrazine (10mg/kg of body weight) daily for 8 days.…”

Section: Procurement and Rearing Of Experimental Animalsmentioning

confidence: 99%

Evaluation of haematinic activity of Kumara Veeriya Kaantha Chendhuram in phenyl hydrazine induced Anemia in experimental rats

T¹,

S²

2023

World J. Bio. Pharm. Health Sci.

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The science of medicine is one of the fundamental requirements to well being of humans and their survival. Siddha system is one of the traditional systems of medicine. According to WHO, anaemia is one of the leading causes of death in worldwide. Anaemia is the most common blood disorder, affecting about one third of the global population. In classical Siddha literature, Kumara Veeriya Kaantha Chendhuram is one of the formulation mentioned in Anupoga Vaithiya Navaneetham – part I helps in overcoming iron deficiency anaemia. The ingredients of the formulation include Kaantham (magnetic oxide of iron) and Thara (Mollugo oppositifolia).The present study aims to evaluate haematinic activity by Phenyl hydrazine induced anaemia in animal models. The evaluation was carried out in Wistar albino rats. The effect of standard drug was comparable to those of the test drug. The blood parameters in animals treated with the test drug exhibited a highly statistical significant elevation when compared to control group.

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“…Concoctions of the aerial and whole plant are claimed to have anti‐diabetic properties (Mahabir & Gulliford, 1997). The plant also possesses anti‐inflammatory, antinociceptive, antioxidant (Onoja et al, 2017), and anti‐hypertensive properties (Abo, Kouakou, & Yapo, 2016; Manda et al, 2011; Yamoah, Adosraku, Amenu, Baah, & Abaye, 2020). The leaf decoction of this plant is used to control anemia in Cameroon (Fongod, Modjenpa, & Veranso, 2013), parts of Nigeria, Congo, parts of Cote d'Ivoire (Fongod et al, 2013) and Madagascar (Moswa et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous extraction and pasteurization of a drink from “Blood Root” (Justicia secunda) leaves stabilized with a natural preservative: Optimization and storage

Neba

Ngwabie

Bup

2021

J Food Process Engineering

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Simultaneous extraction and pasteurization (SEPA) has recently been presented as an appealing process in juice processing because of significant reduction in time, energy consumptions, and production cost resulting from the combination of unit operations. However, the optimum SEPA operating conditions and their effects on the quality and shelf-life of juice are still unmastered. The Doehlert experimental design was used to optimize the SEPA process of juice from Justicia secunda leaves. Optimum conditions for vitamin C retention were temperature (80 C), quantity of ginger (2.6 g/100 ml) and time (20 min) which gave a vitamin C concentration of 4.61 mg/100 ml. The second part of the study evaluated the stability of juice using ginger powder as a natural stabilizer. Results showed that juice produced with and without ginger (WOG) retained 81.27 and 51.18% of their initial vitamin C contents on Day 9 of storage, respectively. Vitamin C content, pH, and acidity showed that addition of ginger preserved the quality of the juice better than that WOG throughout the storage period. Ginger is a natural source of preservative that contributes to the vitamin C content of the juice and extends its shelf-life from 3 to 9 days for storage at room temperature. Practical applications This work describes simple procedures that can be used to extract and pasteurize juice from plant material with simple equipment simultaneously. The optimum conditions that retain more than 90% of the initial vitamin C content of the juice are defined and the use of ginger as a natural preservative that prolongs the shelf-life of the drink at room temperature makes the process very appealing. The process can be easily adapted and used at both laboratory, local and industrial levels to produce juice of good quality. 1 | INTRODUCTION Today, the consumption of juice worldwide is on the rise because of the increasing believe that juices can introduce several nutrients to boost the overall health of an individual. This is because most vegetables and fruits; the major feedstocks for juice extraction are rich in vitamins and minerals. Juice can beef up the human immune system because of its anti-inflammatory properties (Onoja, Ezeja, Omeh, & Onwukwe, 2017). Extraction and pasteurization are some of the critical steps in juice process engineering because a carefully

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Evaluation of the Haematinic Activities of Extracts of Justicia secunda Vahl Leaves in Red Blood Cells of Laboratory Rats

Cited by 6 publications

References 0 publications

Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: <i>Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa</i> and <i>Justicia secunda</i>

Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: <i>Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa</i> and <i>Justicia secunda</i>

Evaluation of haematinic activity of Kumara Veeriya Kaantha Chendhuram in phenyl hydrazine induced Anemia in experimental rats

Simultaneous extraction and pasteurization of a drink from “Blood Root” (Justicia secunda) leaves stabilized with a natural preservative: Optimization and storage

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Evaluation of the Haematinic Activities of Extracts of Justicia secunda Vahl Leaves in Red Blood Cells of Laboratory Rats

Cited by 6 publications

References 0 publications

Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: &lt;i&gt;Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa&lt;/i&gt; and &lt;i&gt;Justicia secunda&lt;/i&gt;

Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: &lt;i&gt;Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa&lt;/i&gt; and &lt;i&gt;Justicia secunda&lt;/i&gt;

Evaluation of haematinic activity of Kumara Veeriya Kaantha Chendhuram in phenyl hydrazine induced Anemia in experimental rats

Simultaneous extraction and pasteurization of a drink from “Blood Root” (Justicia secunda) leaves stabilized with a natural preservative: Optimization and storage

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Product

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Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: <i>Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa</i> and <i>Justicia secunda</i>

Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: <i>Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa</i> and <i>Justicia secunda</i>