Evaluation of the hemocompatibility of hydrated biodegradable aliphatic carbonyl polymers with a subtle difference in the backbone structure based on the intermediate water concept and surface hydration

Fukushima, Kazuki; Tsai, Meng Yu; Ota, Takayuki; Haga, Yuta; Matsuzaki, Kodai; Inoue, Yoshihisa; Tanaka, Masaru

doi:10.1038/pj.2015.22

Cited by 18 publications

(22 citation statements)

References 20 publications

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“…Thus, we have investigated platelet adhesion and hydration properties of the aliphatic carbonyl polymers using PTMC, PCL, poly(δ-valerolactone) (PVL), and poly(p-dioxanone) (PPDO) as commercially available biodegradable polymers with no side group (Figure 16(a)). 151 As described above, these polymers are not sufficiently blood compatible regarding platelet adhesion. However, the platelet adhesion level of these polymers is lower than that of an aromatic polyester PET (Figure 16(b)), even though water contact angles of the polymers are similar, indicating that types and structure of the hydrated water at the polymer interface are different.…”

Section: Hydration Of Aliphatic Polyesters and Polycarbonates And Itsmentioning

confidence: 99%

Design of Polymeric Biomaterials: The “Intermediate Water Concept”

Tanaka

Kobayashi

Murakami

et al. 2019

Bulletin of the Chemical Society of Japan

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During this period, he received a fellowship from the Japan Society for the Promotion of Science (JSPS Postdoctoral Fellowships). He worked as a researcher at Japan Science and Technology Agency (JAT) ERATO Project and Kyushu Synchrotron Light Research Center. He moved to Kyushu University as an Assistant Professor in 2015. His current research activities are concerned with the analysis of structure, properties, and hydration state of biomaterial interfaces.

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Section: Hydration Of Aliphatic Polyesters and Polycarbonates And Itsmentioning

confidence: 99%

Design of Polymeric Biomaterials: The “Intermediate Water Concept”

Tanaka

Kobayashi

Murakami

et al. 2019

Bulletin of the Chemical Society of Japan

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“…Tanaka and collaborators [ 62 ] studied PDO, PCL and PTMC (see Nomenclature Section) in addition to poly(δ-valerolactone) (PVL) ( Figure 13 ) in order to elucidate the differences in their backbone structure on hydration and hemocompatibility. They found that a higher amount of intermediate water in PDO is related to its good hemocompatibility and the presence of ether bonds in the main chain of PDO are involved in the hydration and formation of intermediate water.…”

Section: Studies On the States Of Water On Polymers And Their Effementioning

confidence: 99%

“…At first glance at Figure 14 , one could conclude that there is an inverse relationship between the number of platelets and the amount of intermediate water. However, the actual amount of intermediate water on PTMC might be overestimated because the author hypothesized that this water is not in the hydration layer formed by the polymeric chains and water, but spreads over this layer [ 62 ]. Therefore, the data of PTMC in Figure 14 should be closer to the Y-axis next to PCL and PVL, and the inverse relation is not conclusive anymore.…”

Section: Studies On the States Of Water On Polymers And Their Effementioning

confidence: 99%

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Impact of the Hydration States of Polymers on Their Hemocompatibility for Medical Applications: A Review

Bag

Valenzuela

2017

IJMS

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Water has a key role in the functioning of all biological systems, it mediates many biochemical reactions, as well as other biological activities such as material biocompatibility. Water is often considered as an inert solvent, however at the molecular level, it shows different behavior when sorbed onto surfaces like polymeric implants. Three states of water have been recognized: non-freezable water, which does not freeze even at −100 °C; intermediate water, which freezes below 0 °C; and, free water, which freezes at 0 °C like bulk water. This review describes the different states of water and the techniques for their identification and quantification, and analyzes their relationship with hemocompatibility in polymer surfaces. Intermediate water content higher than 3 wt % is related to better hemocompatibility for poly(ethylene glycol), poly(meth)acrylates, aliphatic carbonyls, and poly(lactic-co-glycolic acid) surfaces. Therefore, characterizing water states in addition to water content is key for polymer selection and material design for medical applications.

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“…As the PTMC International possesses more hydroxyl termini, it is liable to absorb water and is not as subject to enzymatic degradation. 32,33 Overall, the release of VCM/TMC NP-PTMC may be better for the prolonged administration of antibiotics. 34 Protein adsorption was enhanced in the VCM/TMC NP-PTMC, mainly due to 1) the presence of NPs that increase the total surface area and binding sites for proteins or 2) an electrostatic interaction between the material surface and proteins.…”

mentioning

confidence: 99%

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

Zhang¹,

Liang²,

Xu³

et al. 2017

IJN

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Surgery and the local placement of an antibiotic are the predominant therapies to treat chronic osteomyelitis. Vancomycin-loaded N -trimethyl chitosan nanoparticles (VCM/TMC NPs) as a potential drug delivery system have high intracellular penetration and effective intracellular antibacterial activity. This study investigated the effects of a biocompatible material, poly(trimethylene carbonate) (PTMC), to increase the sustained effectiveness of an intracellular antibiotic and its potential application in antibiotic delivery. VCM/TMC NP-PTMC was characterized using scanning electron microscopy and Fourier transform infrared spectroscopy to determine the morphology, stability and chemical interaction of the drug with the polymer. Further, the biodegradation, antibacterial activity, protein adsorption, cell proliferation and drug release characteristics were evaluated. In addition, a Staphylococcus aureus -induced osteomyelitis rabbit model was used to investigate the antibiotic activity and bone repair capability of VCM/TMC NP-PTMC. The results showed that the composite beads of VCM/TMC NPs followed a sustained and slow release pattern and had excellent antibacterial activity and a higher protein adsorption and cell proliferation rate than the VCM-PTMC in vitro. Furthermore, VCM/TMC NP-PTMC inhibits bacteria and promotes bone repair in vivo. Thus, VCM/TMC NP-PTMC might be beneficial in periodontal management to reduce the bacterial load at the infection site and promote bone repair.

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Evaluation of the hemocompatibility of hydrated biodegradable aliphatic carbonyl polymers with a subtle difference in the backbone structure based on the intermediate water concept and surface hydration

Cited by 18 publications

References 20 publications

Design of Polymeric Biomaterials: The “Intermediate Water Concept”

Design of Polymeric Biomaterials: The “Intermediate Water Concept”

Impact of the Hydration States of Polymers on Their Hemocompatibility for Medical Applications: A Review

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

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