Evaluation of the hypoglycemic and hypolipidemic effects of an ethylacetate fraction of Artocarpus heterophyllus (jak) leaves in streptozotocin-induced diabetic rats

Chackrewarthy, S.; Thabrew, M.I.; Weerasuriya, M K B; Jayasekera, S.

doi:10.4103/0973-1296.66933

Cited by 41 publications

(24 citation statements)

References 16 publications

(17 reference statements)

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“…In STZ-induced diabetic rats, chronic administration of the ethylacetate fraction of A. heterophyllus leaves daily (20 mg/kg) for 5 weeks resulted in a significant lowering of serum glucose (39%), cholesterol (23%) and triglyceride levels (40%) compared to control group. Such results mediated by the extract were comparable with those produced by glibenclamide (0.6 mg/kg) [63]. Pressurized hot water extract of A. heterophyllus seeds was observed to possess a significant antiglycation activity [68].…”

Section: The Renaissance Of Food Plants As Therapeutic Agentsmentioning

confidence: 63%

The Therapeutic Potential of Medicinal Foods

Ramalingum

Mahomoodally

2014

Advances in Pharmacological Sciences

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Pharmaceutical and nutritional sciences have recently witnessed a bloom in the scientific literature geared towards the use of food plants for their diversified health benefits and potential clinical applications. Health professionals now recognize that a synergism of drug therapy and nutrition might confer optimum outcomes in the fight against diseases. The prophylactic benefits of food plants are being investigated for potential use as novel medicinal remedies due to the presence of pharmacologically active compounds. Although the availability of scientific data is rapidly growing, there is still a paucity of updated compilation of data and concerns about the rationale of these health-foods still persist in the literature. This paper attempts to congregate the nutritional value, phytochemical composition, traditional uses, in vitro and in vivo studies of 10 common medicinal food plants used against chronic noncommunicable and infectious diseases. Food plants included were based on the criteria that they are consumed as a common food in a typical diet as either fruit or vegetable for their nutritive value but have also other parts which are in common use in folk medicine. The potential challenges of incorporating these medicinal foods in the diet which offers prospective opportunities for future drug development are also discussed.

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Section: The Renaissance Of Food Plants As Therapeutic Agentsmentioning

confidence: 63%

The Therapeutic Potential of Medicinal Foods

Ramalingum

Mahomoodally

2014

Advances in Pharmacological Sciences

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“…As insulin is the main regulator of glycogenesis, so the decreased levels of glycogen may be due to the lack of insulin in the diabetic state, [33,34] or diabetes-induced oxidative stress may inactivate glycogen synthetase. [35] The hydromethanol extract of the bark of T. grandis treated diabetic animals resulted in a signifi cant recovery in hepatic and skeletal muscular glycogen contents which may be due to increased insulin activation or insulin release or target cell sensitivity to insulin, which is supported by others.…”

Section: Discussionmentioning

confidence: 99%

Effect of the hydro-methanolic (2:3) extract of the bark of Tectona grandis L. on the management of hyperglycemia and oxidative stress in streptozotocin-induced diabetes in rats

De¹,

Ali²,

Ghosh³

et al. 2011

J Nat Pharm

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Background: Natural products are considered to be effective and safe alternative treatment for the management of diabetes. So, the aim of this study was to fi nd out the antihyperglycemic and antioxidative effi cacy of the hydro-methanolic (2:3) extract of the bark of Tectona grandis in experimental diabetic rats. Materials and Methods: All chemicals were purchased from Sigma (USA). Diabetes was induced in rats by a single intramuscular injection of streptozotocin. The hydro-methanolic extract of the bark of T. grandis was prepared according to the standard method. The fasting blood glucose (FBG) level was measured by a glucometer. Activities of carbohydrate metabolic enzymes, antioxidant enzymes, and glycogen levels in liver, kidney, and skeletal muscular tissues were measured biochemically. Activities of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase were assessed spectrophotometrically. Results: The FBG level, activities of carbohydrate metabolic enzymes like glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, hexokinase in liver along with the quantity of glycogen in the liver and skeletal muscles were signifi cantly (P < 0.05) recovered by the extract compared to untreated diabetic rats. A signifi cant recovery (P < 0.05) was observed in the activities of antioxidant enzymes, i.e. catalase, peroxidase as well as the levels of conjugated diene and thiobarbituric acid reactive substances in the liver and kidney of extract-treated diabetic rats compared with untreated diabetic rats. Extract-treated diabetic animals also showed a signifi cant (P < 0.05) correction in the activities of glutamate oxaloacetate transaminase and glutamate pyruvate transaminase in the serum compared to untreated diabetic animals. The antidiabetic effi cacy of the extract was compared with glibenclamide. Conclusion: The results indicated that the hydro-methanolic extract of the bark of T. grandis has remedial effects on hyperglycemia and oxidative stress in diabetic rats.

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“…Lipid peroxide-mediated tissue damage has been observed in the development of type 1 and type II diabetes. [15]…”

Section: Discussionmentioning

confidence: 99%

Effect of the hexane extract of Piper auritum on insulin release from β-cell and oxidative stress in streptozotocin-induced diabetic rat

Gutierrez

2012

Phcog Mag

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Background:The large-leafed perennial plant Piper auritum known as Hoja Santa, is used for its leaves that because of their spicy aromatic scent and flavor have an important presence in Mexican cuisine, and in many regions, this plant is known for its therapeutic properties.Materials and Methods:In the present study, we investigated the effect of hexane, chloroform and methanol extracts from Piper auritum on cell culture system and the effect in streptozotocin-induced type 1 diabetic rats treated by 28 days on the physiological, metabolic parameters and oxidative stress.Results:The hexane extract of P. auritum (HS) treatment significantly reduced the intake of both food, water and body weight loss as well as levels of blood glucose, serum cholesterol, triglycerides and increase HDL-cholesterol. After 4-week administration of HS antioxidant enzyme as SOD, CAT, GSH, GPx in pancreas were determined. These enzyme increased significantly compared with those of the diabetic rats control and normal animals. For all estimated, the results of HS treated groups leading to a restoration of the defense mechanism. The treatment also improves pancreatic TBARS–reactive substance level and serum NO and iNOS. To determine the insulin releasing activity, after extract treatment the serum and pancreatic sections were processed for examination of insulin-releasing activity using an immunocytochemistry kit. The results showed that administration of the hexane extract (200 and 400 mg/kg) exhibited a significant increase in serum and pancreas tissue insulin. Administration of streptozotocin decreased the insulin secretory activity in comparison with intact rats, but treatment with the HS extract increased significantly the activity of the beta cells in comparison with the diabetic control rats. The extract decreased serum glucose in streptozotocin-induced diabetic rats and increased insulin release from the beta cells of the pancreas. In cultured RIN-5F cells, we examined whether hexane extract of P. auritum would protect the pancreas-derived β-cells from oxidative stress. Moreover, HS could protect pancreatic β-cells from advanced glycation end products-induced oxidative stress.Conclusion:From these results, HS is suggested to show anti-diabetic effect by stimulating insulin-dependent and by protecting pancreatic β-cells from advanced glycation end products-induced oxidative stress.

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Evaluation of the hypoglycemic and hypolipidemic effects of an ethylacetate fraction of Artocarpus heterophyllus (jak) leaves in streptozotocin-induced diabetic rats

Cited by 41 publications

References 16 publications

The Therapeutic Potential of Medicinal Foods

The Therapeutic Potential of Medicinal Foods

Effect of the hydro-methanolic (2:3) extract of the bark of Tectona grandis L. on the management of hyperglycemia and oxidative stress in streptozotocin-induced diabetes in rats

Effect of the hexane extract of Piper auritum on insulin release from β-cell and oxidative stress in streptozotocin-induced diabetic rat

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