Evaluation of the impact of Chernobyl on the prevalence of congenital anomalies in 16 regions of Europe. EUROCAT Working Group

Dolk, Helen; Nichols, Richard D.

doi:10.1093/ije/28.5.941

Cited by 54 publications

(42 citation statements)

References 20 publications

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“…188,189 Surveillance data from population-based congenital anomaly registers in 16 regions of Europe (mainly Western Europe) were analyzed to evaluate the impact of the Chernobyl accident on the prevalence of selected congenital anomalies. 190 Chernobyl had no detectable impact on the prevalence of congenital anomalies in Western Europe.…”

Section: Other Environmental Concernsmentioning

confidence: 95%

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Jenkins¹,

Correa²,

Feinstein³

et al. 2007

Circulation

711

336

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Abstract-Prevention of congenital cardiovascular defects has been hampered by a lack of information about modifiable risk factors for abnormalities in cardiac development. Over the past decade, there have been major breakthroughs in the understanding of inherited causes of congenital heart disease, including the identification of specific genetic abnormalities for some types of malformations. Although relatively less information has been available on noninherited modifiable factors that may have an adverse effect on the fetal heart, there is a growing body of epidemiological literature on this topic. This statement summarizes the currently available literature on potential fetal exposures that might alter risk for cardiovascular defects. Information is summarized for periconceptional multivitamin or folic acid intake, which may reduce the risk of cardiac disease in the fetus, and for additional types of potential exposures that may increase the risk, including maternal illnesses, maternal therapeutic and nontherapeutic drug exposures, environmental exposures, and paternal exposures. Information is highlighted regarding definitive risk factors such as maternal rubella; phenylketonuria; pregestational diabetes; exposure to thalidomide, vitamin A cogeners, or retinoids; and indomethacin tocolysis. Caveats regarding interpretation of possible exposure-outcome relationships from case-control studies are given because this type of study has provided most of the available information. Guidelines for prospective parents that could reduce the likelihood that their child will have a major cardiac malformation are given. Issues related to pregnancy monitoring are discussed. Knowledge gaps and future sources of new information on risk factors are described.

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Section: Other Environmental Concernsmentioning

confidence: 95%

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Jenkins¹,

Correa²,

Feinstein³

et al. 2007

Circulation

711

336

View full text Add to dashboard Cite

show abstract

“…Therefore, the impact of the Chernobyl accident on the increased prevalence of Down syndrome in Western Europe during the 1980s merits further investigation (Dolk and Nichols 1999). …”

mentioning

confidence: 99%

QF-PCR Examination of Parental and Meiotic Origin of Trisomy 21 in Central and Eastern Europe

Machatková

Brouckova

Matějčková

et al. 2005

J Histochem Cytochem.

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Study of parental/meiotic origin of free trisomy 21 in nuclear families from Russia (70 cases), Ukraine (32 cases), and 22 from Germany revealed maternal nondisjunction in 77.3% (Germany), 93.8% (Ukraine), and 91.4% (Russia), paternal origin in 13.6%, 6.2%, and 8.6%, respectively. Maternal meiosis I errors were found in 84.4% (Ukraine), 77.1% (Russia), paternal origin in 3.1% (Ukraine), 2.9% (Russia). Maternal meiosis II errors occurred in 9.4% and 14.3% and paternal in 3.1% and 5.7% in Ukraine and Russia, respectively. No significant differences were found in maternal/paternal origin among Ukraine, Russia, Germany, and published data from other European regions.

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“…По результатам исследова-ний не было выявлено ассоциации между воздействием ионизирующей радиации и формированием ВПС, в т. ч. при анализе данных об аварии на Чернобыльской атом-ной электростанции [4,58].…”

Section: воздействия окружающей средыunclassified

Congenital Heart Diseases in Children: Incidence, Risk Factors, Mortality

Саперова¹,

Вахлова²

2017

Vopr. sovr. pediatr.

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Evaluation of the impact of Chernobyl on the prevalence of congenital anomalies in 16 regions of Europe. EUROCAT Working Group

Cited by 54 publications

References 20 publications

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

QF-PCR Examination of Parental and Meiotic Origin of Trisomy 21 in Central and Eastern Europe

Congenital Heart Diseases in Children: Incidence, Risk Factors, Mortality

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