2016
DOI: 10.1590/s1984-82502016000400021
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Evaluation of the impact of orally administered carbohydrates on postprandial blood glucose levels in different pre-clinical models

Abstract: We developed a pre-clinical model in which to evaluate the impact of orally administered carbohydrates on postprandial blood glucose levels. For this purpose, we compared the effects of different carbohydrates with well-established glycemic indexes. We orally administered (gavage) increasing amounts (0.2, 0.4, 0.6, 0.8, and 1.0 g/kg) of sucrose and lactose to rats which had been fasted for 6 h or 15 h, respectively. In part of the experiments we administered frutose (gavagem). Three different models were compa… Show more

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Cited by 4 publications
(1 citation statement)
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“…Mice were divided into 8 groups (n = 3-4 per group) which were given increasing ip doses of insulin: (0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, or 10.0 U/kg). Blood samples were collected from the tail at 0, 30, 60, 90, and 120 min after insulin injection, as previously described (Marques et al, 2016). Glycemia (mmol/L) was evaluated with a home glucometer (Optium Xceed®, Abbott Laboratories, Chicago, IL, USA), which is known to show good accuracy compared with the gold standard method used to measure plasma glucose (Robinson, Sharp, 2012).…”
Section: Dose Response Curve and Seizuresmentioning
confidence: 99%
“…Mice were divided into 8 groups (n = 3-4 per group) which were given increasing ip doses of insulin: (0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0, or 10.0 U/kg). Blood samples were collected from the tail at 0, 30, 60, 90, and 120 min after insulin injection, as previously described (Marques et al, 2016). Glycemia (mmol/L) was evaluated with a home glucometer (Optium Xceed®, Abbott Laboratories, Chicago, IL, USA), which is known to show good accuracy compared with the gold standard method used to measure plasma glucose (Robinson, Sharp, 2012).…”
Section: Dose Response Curve and Seizuresmentioning
confidence: 99%