Remand prisoners (RP) are non-sentenced individuals who must be held in prison awaiting sentencing. The international data reported that up to a third of the detainees worldwide are in a pre-trial situation. The present systematic review aims to review the studies that assessed the remand prisoners' mental problems during detention. Following the PICO strategy, the search identified a total of 5427 studies, of which, 79 studies were included in the final analysis. Substance use disorders were the most reported problem, followed by mood disorders, psychotic disorders, and personality and behavior disorders. A smaller number of studies reported anxiety and neurotic disorders, posttraumatic stress disorder and adjustment disorders, intellectual disorders, paraphilias and sexual disorders, attention-deficit hyperactivity disorder, obsessive-compulsive disorder, eating disorders, and somatoform disorders. Our findings contribute to the scientific knowledge about this group of inmates' needs, emphasizing the prevalence of mental problems within this population and supporting both professionals and academics to reform policies and practices.