Evaluation of the in vivo cosmetic efficacy of the MF3 blue cell serum gel. One‐ and two‐month test results

Tulina, Dina; Béguin, Alain; Pong, Henry; Cabarbas, Maria Del Mar; Klokol, Dmitry; Chan, Mike Ks; Wong, Michelle Bf

doi:10.1111/jocd.12363

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…The formulations containing anti‐aging and whitening agents and UV‐filters separated and in combination (CA, CF, and CM treatments) significantly increased skin brightness on both populations under the study conditions. According to previous studies, an increase in this property means greater radiance of the skin, greater homogeneity of the skin color and its surface . Thus, it suggests that the presence of the whitening agents and UV‐filters was responsible for this improvement.…”

Section: Discussionmentioning

confidence: 82%

“…According to previous studies, an increase in this property means greater radiance of the skin, greater homogeneity of the skin color and its surface. 22,35 Thus, it suggests that the presence of the whitening agents and UV-filters was responsible for this improvement. This information corroborates with the results of decreased TEWL and increased skin hydration, indicating the filmforming effect on the skin.…”

Section: Efficacy Of Treatmentsmentioning

confidence: 98%

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Skin characterization and immediate effects of different dermocosmetic treatments in French and Brazilian skin

Calixto

Picard

Savary

et al. 2019

J of Cosmetic Dermatology

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Choosing the right treatment for each type of skin is a challenge faced every day by prescribers and formulators. It is necessary that the treatments be efficient in the diverse types of skin.Many differences can be found in the skin of people from different continents. [1][2][3] Physical distance brings changes in environmental and socioeconomic factors, climate and behavior of populations, which is reflected in their skin. But not going that far, studies show that it is possible to find differences in the skin of people from the same continent 4-7 and even within the population of the same country. 8,9 Countries like Brazil and France are multi-ethnic, that is, to say, they present in their population people with different progeny that have different skin. 10,11 That is why studies focusing on the skins of these populations are important to know the structural composition of their skin, as well as their response to different treatments.Observations across countries are important because they bring extensive knowledge about each region and cross the information to obtain important conclusions for several countries. Differences in skin structure and function can be marked. Skin colors, stratum corneum pH gradient, lipid organization, and composition of stratum corneum sheets are characteristics that can be studied, as well

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Section: Discussionmentioning

confidence: 82%

Section: Efficacy Of Treatmentsmentioning

confidence: 98%

Skin characterization and immediate effects of different dermocosmetic treatments in French and Brazilian skin

Calixto

Picard

Savary

et al. 2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…18 According to dermis imaging analyses, it is possible to observe that both treatments were effective in the improvement of the dermis echogenicity, but the effects with the oral treatment were more pronounced, as it acts on the skin from deeper layers, which are the mechanism to the improvement of dermis. 19 In summary, the topical application of peptides acted in the clinical efficacy with significant results on the hydration, skin elasticity, and wrinkles reduction parameters, with short-term effects.…”

Section: Discussionmentioning

confidence: 98%

“…This result is related to the dermis morphology, presenting an increase in fibroblast density, greater formation of collagen fibrils, and repair of the present damages, helping in the chronological aging and photoaging process, improving the skin density . According to dermis imaging analyses, it is possible to observe that both treatments were effective in the improvement of the dermis echogenicity, but the effects with the oral treatment were more pronounced, as it acts on the skin from deeper layers, which are the mechanism to the improvement of dermis …”

Section: Discussionmentioning

confidence: 99%

Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density

Campos

Melo

César

2019

J of Cosmetic Dermatology

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Summary Background The combination of oral supplementation and topical formulations to the improvement of skin conditions has been proposed as an innovative approach to obtain effective treatments. However, studies comparing the effectiveness of each type of treatments are still in lack. This way, the objective of this work was to evaluate the clinical efficacy of a dermocosmetic formulation with di‐ and tripeptides, as well the effects of an oral supplementation based on hydrolyzed collagen through biophysical and skin imaging techniques. Methods Sixty healthy female subjects, aged between 40 and 50 years, were enrolled, being separated in 3 groups: topical formulation, oral supplementation, and oral placebo. The stratum corneum water content, skin viscoelasticity, dermis echogenicity, and skin pores parameters were evaluated. Results The group with the topical formulation showed a significant increase in the stratum corneum water content and skin elasticity after 28‐day period and also acted in the dermis echogenicity after 90 days with the formulation with peptides. The oral supplementation acted on skin elasticity and presented a more pronounced effect on dermis echogenicity, reducing skin pores after 90‐day period. Conclusion The obtained results with oral supplementation and topical application of hydrolyzed proteins were considered complementary in the improvement of general skin conditions, acting in different mechanisms.

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“…The color of the skin was assessed at various timepoints: before the application of the model dirt (baseline), and before and after cleansing with the model dirt in the three groups. The assessment was performed using the Visioscan ® VC 20plus and colorimeter CL 400, as detailed in references [47,48]. To evaluate the efficacy of dirt removal, the color of the porcine skin after cleansing was compared to its color before and after the application of the model dirt at the same sites.…”

Section: Preparation Of Porcine Skin and Application Of Model Dirtmentioning

confidence: 99%

Development of Effervescent Cleansing Tablets Containing Asiatic-Acid-Loaded Solid Lipid Microparticles

Mang Sung Thluai,

Titapiwatanakun,

Ruksiriwanich

et al. 2023

Cosmetics

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The objective of this study was to develop effervescent cleansing tablets that can be dissolved and turned into liquid soap, which can be used for bathing or soaking the body. The asiatic-acid-loaded solid lipid microparticles (AASLMs) were prepared via the hot emulsification method followed by cold re-solidification and then freeze-dried to obtained dry powder. The physicochemical properties such as morphology and % entrapment efficiency (%EE) were evaluated. The results revealed that AASLMs have an irregular shape, and the %EE for the resulting AASLMs was 92.04 ± 3.43%. The tablets were manufactured via the direct compression technique. The compatibility test was conducted to ensure that the excipients are compatible with the active ingredient. The angle of repose, Carr’s index, and Hausner’s ratio were studied to evaluate the flowability of the powder blend before compression. The weight of each tablet was set to 1000 mg, and physicochemical characteristics, in vitro dissolution, ex vivo cleansing efficacy, and stability were evaluated. The results showed that the active ingredient was compatible with other excipients, as the results obtained from FTIR spectra indicated the absence of potential chemical interaction between the active ingredient and excipients used in this study. Additionally, all formulations had good flow properties. The effervescence times of selected formulations, F2 and F3, were <5 min, with favorable pH and hardness values. The friability values of all formulations exceeded 1% because the excipients used in effervescent tablets are very fragile. The release of asiatic acid (AA) from the tablets was dependent on the concentration of SLS. In an ex vivo test, it was discovered that the developed products F2 and F3 showed much more effective cleansing efficacy than water. Nevertheless, brown spots appeared in the tablets and the AA content was significantly decreased in both tested formulations after 3 months’ storage at 40 ± 2 °C/75% RH ± 5% RH. The stability study revealed that the developed products were not stable at high temperature and humidity. Therefore, it is recommended that the developed effervescent tablets are not stored at a high temperature.

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Evaluation of the in vivo cosmetic efficacy of the MF3 blue cell serum gel. One‐ and two‐month test results

Abstract: Twice daily application of MF3 Blue Cell Serum Gel led to significant improvement in skin hydration, firmness, dermal density, sebum regulation, roughness reduction, decrease or disappearance of fine lines and wrinkles.

Cited by 7 publications

References 16 publications

Skin characterization and immediate effects of different dermocosmetic treatments in French and Brazilian skin

Skin characterization and immediate effects of different dermocosmetic treatments in French and Brazilian skin

Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density

Development of Effervescent Cleansing Tablets Containing Asiatic-Acid-Loaded Solid Lipid Microparticles

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