Evaluation of the inhibitory effect of various drugs / active ingredients on the activity of human diamine oxidase <i>in vitro</i>

Leitner, Roland; Zoernpfenning, Eva; Missbichler, Albert

doi:10.1186/2045-7022-4-s3-p23

Cited by 25 publications

(23 citation statements)

References 3 publications

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“…It has been estimated that approximately 20% of the European population regularly take DAO-inhibiting drugs, which significantly increases the number of people susceptible to the adverse effects of dietary histamine [ 28 ]. In vitro experimental results show a potent inhibitory effect (greater than 90%) of chloroquine, a historical antimalarial active ingredient, and clavulanic acid, a β-lactam antibiotic widely used in combination with amoxicillin [ 80 ]. A significant inhibition of the enzymatic activity has also been observed with the antihypertensive drug verapamil and the histamine H2 receptor antagonist cimetidine, although the clinical use of the latter is currently anecdotal [ 23 , 80 ].…”

Section: Histamine Intolerancementioning

confidence: 99%

“…In vitro experimental results show a potent inhibitory effect (greater than 90%) of chloroquine, a historical antimalarial active ingredient, and clavulanic acid, a β-lactam antibiotic widely used in combination with amoxicillin [ 80 ]. A significant inhibition of the enzymatic activity has also been observed with the antihypertensive drug verapamil and the histamine H2 receptor antagonist cimetidine, although the clinical use of the latter is currently anecdotal [ 23 , 80 ]. Other substances have also shown an inhibitory effect, albeit to a lesser extent ( Table 2 ) [ 23 , 80 , 81 ].…”

Section: Histamine Intolerancementioning

confidence: 99%

“…A significant inhibition of the enzymatic activity has also been observed with the antihypertensive drug verapamil and the histamine H2 receptor antagonist cimetidine, although the clinical use of the latter is currently anecdotal [ 23 , 80 ]. Other substances have also shown an inhibitory effect, albeit to a lesser extent ( Table 2 ) [ 23 , 80 , 81 ]. In most cases, the structural similarity of the cited drugs with histamine could explain their potential to bind to the active site of DAO and reduce its enzymatic activity [ 23 ].…”

Section: Histamine Intolerancementioning

confidence: 99%

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Histamine Intolerance: The Current State of the Art

et al. 2020

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Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the 21st century. Although interest in histamine intolerance has considerably grown in recent years, more scientific evidence is still required to help define, diagnose and clinically manage this condition. This article will provide an updated review on histamine intolerance, mainly focusing on its etiology and the existing diagnostic and treatment strategies. In this work, a glance on histamine intoxication will also be provided, as well as the analysis of some uncertainties historically associated to histamine intoxication outbreaks that may be better explained by the existence of interindividual susceptibility to ingested histamine.

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Section: Histamine Intolerancementioning

confidence: 99%

Section: Histamine Intolerancementioning

confidence: 99%

Section: Histamine Intolerancementioning

confidence: 99%

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Histamine Intolerance: The Current State of the Art

et al. 2020

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“…The genes coding for DAO and HNMT enzymes are polymorphic and 7 diverse SNPs (single nucleotide polymorphisms) for DAO were significantly related with DAO serum activity [2]. The minor allele at rs2052129 was associated with a lower DAO mRNA expression for the homozygous minor allele, lower promoter activity and subsequently the increased risk of a reduced DAO activity [3]. Another mechanism reducing DAO bioavailability might be related to medicines containing active agents against DAO.…”

Section: Introductionmentioning

confidence: 99%

“…Another mechanism reducing DAO bioavailability might be related to medicines containing active agents against DAO. According to Leitner et al , common drugs or active ingredients such as cimetidine, verapamil, chloroquine and clavulanic acid are able to markedly reduce DAO activity by 50–90% [3]. Moderate influence on DAO was caused by isoniazid and metamizole, acetyl cysteine and amitriptyline (> 20%).…”

Section: Introductionmentioning

confidence: 99%

Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients

Wagner¹,

Buczyłko²,

Zielińska‐Bliźniewska³

et al. 2019

pdia

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IntroductionHistamine is the major mediator of IgE- and non-IgE-mediated allergic reactions upon allergen or hapten contact. Reduced histamine degradation capacity was associated with atopic eczema as well as with non-immunological histamine intolerance. Higher blood serum histamine level concomitant with decreased intestinal diamine oxidase activity were observed in patients with food allergy.AimTo evaluate the relationship between patients’ blood diamine oxidase (DAO) activity/histamine status and their reactivity to time-resolved histamine skin prick test in respect to vulnerability to allergic diseases.Material and methodsFifty-three patients were examined with skin prick tests (SPT) and patch tests for suspected presence of either IgE- or non-IgE-mediated allergy. All individuals were skin prick tested with histamine and the resolution of the wheal was monitored for 50 min. Blood DAO activity and histamine concentration were measured with a radio-extraction radioimmunoassay.ResultsTime-resolved histamine skin prick testing revealed presence of wheals which were 35% larger in diameter in 47% of examined subjects at 20 min of the test. These patients exhibited significantly compromised time-course wheal resolution (wheal ≥ 3 mm at 50 min) compared to a group of patients with the normal-rate of wheal resolution (wheal = 0 mm at 50 min). Within a group of subjects exhibiting impaired wheal resolution, 61% of patients were diagnosed allergic compared to 50% in a group of patients with a normal rate of wheal resolution. Finally, allergic patients were characterized by a significantly lower DAO activity and higher histamine content compared to healthy subjects.ConclusionsThe results of this study indicate that patients with IgE- or non-IgE-mediated allergy are likely to have low DAO blood activity and may concomitantly suffer from histamine intolerance. Furthermore, our results suggest that allergic patients are more likely to develop an excessive SPT reaction. Our results emphasize caution in interpretation of the SPT results in allergic patients with diagnosed histamine intolerance or histamine/DAO activity imbalance.

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Nahrungsmittelunverträglichkeiten des Verdauungstraktes – Teil 2: Nahrungsmittelintoleranzen

Bischoff

2022

Internist

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Evaluation of the inhibitory effect of various drugs / active ingredients on the activity of human diamine oxidase in vitro

Cited by 25 publications

References 3 publications

Histamine Intolerance: The Current State of the Art

Histamine Intolerance: The Current State of the Art

Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients

Nahrungsmittelunverträglichkeiten des Verdauungstraktes – Teil 2: Nahrungsmittelintoleranzen

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