Evaluation of the insulin-like growth factors (IGF) IGF-I and IGF binding protein 3 in patients at high risk for breast cancer

Trinconi, Angela Francisca; Filassi, José Roberto; Soares-Júnior, José Maria; Baracat, Edmund C.

doi:10.1016/j.fertnstert.2011.02.014

Cited by 12 publications

(12 citation statements)

References 25 publications

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“…Since the presence of a malignant disease itself might affect the IGF‐I status, assessment of the IGF‐I status from case–control studies might reflect the alteration of the IGF‐I status in BC patients rather than the risk assessment of BC . In this case–control study, we found that levels of both IGF‐I and IGFBP‐3 in the women with BC were not significantly different from those in the controls no matter what the menopausal status was, which was consistent with previous studies . In the present study, the ratios of IGF‐I/IGFBP‐3 were significantly higher in the women with BC than those in the controls regardless of their menopausal statuses.…”

Section: Discussionsupporting

confidence: 91%

“…Although the levels of IGF‐I were positively associated and the levels of IGFBP‐3 were negatively associated with risks of breast cancer , several studies did not support the concepts. The diverse results could be due to the influences of ages and menopausal statuses that were found to have statistically different distribution between BC subtypes of ER, PR, and HER2 on the levels of IGF‐I and IGFBP‐3 .…”

Section: Introductionmentioning

confidence: 99%

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Increased Igf‐I/Igfbp‐3 Ratios in Postmenopausal Taiwanese with Breast Cancer, Irrespective of Er and Pr Statuses and Her2 Expression in a Case–Control Study

Lee

Hou

Tien

et al. 2014

Clinical Laboratory Analysis

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Increased Igf‐I/Igfbp‐3 Ratios in Postmenopausal Taiwanese with Breast Cancer, Irrespective of Er and Pr Statuses and Her2 Expression in a Case–Control Study

Lee

Hou

Tien

et al. 2014

Clinical Laboratory Analysis

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“…Associations of IGF1 and IGF1/IGFBP3 ratio with mortality in women with breast cancer have also been reported (Duggan et al 2012, Izzo et al 2012. However, all these data need to be confirmed in larger breast cancer survivor cohorts, considering that other reports have indicated that serum concentrations of IGF1 and IGFBP3 do not correlate with breast cancer development/risk (Trinconi et al 2011).…”

Section: Ilp Molecules and Cancer Riskmentioning

confidence: 90%

Insulin resistance and cancer: the role of insulin and IGFs

Djiogue¹,

Kamdje²,

Vecchio³

et al. 2012

Endocrine-Related Cancer

232

188

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Insulin, IGF1, and IGF2 are the most studied insulin-like peptides (ILPs). These are evolutionary conserved factors well known as key regulators of energy metabolism and growth, with crucial roles in insulin resistance-related metabolic disorders such as obesity, diseases like type 2 diabetes mellitus, as well as associated immune deregulations. A growing body of evidence suggests that insulin and IGF1 receptors mediate their effects on regulating cell proliferation, differentiation, apoptosis, glucose transport, and energy metabolism by signaling downstream through insulin receptor substrate molecules and thus play a pivotal role in cell fate determination. Despite the emerging evidence from epidemiological studies on the possible relationship between insulin resistance and cancer, our understanding on the cellular and molecular mechanisms that might account for this relationship remains incompletely understood. The involvement of IGFs in carcinogenesis is attributed to their role in linking high energy intake, increased cell proliferation, and suppression of apoptosis to cancer risks, which has been proposed as the key mechanism bridging insulin resistance and cancer. The present review summarizes and discusses evidence highlighting recent advances in our understanding on the role of ILPs as the link between insulin resistance and cancer and between immune deregulation and cancer in obesity, as well as those areas where there remains a paucity of data. It is anticipated that issues discussed in this paper will also recover new therapeutic targets that can assist in diagnostic screening and novel approaches to controlling tumor development.

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“…Serum IGF-1 levels have also been positively associated with increased disease risk among BRCA gene mutation carriers (hereditary BrCa) in an Italian cohort study [ 22 ]. In contrast no correlation was found between IGF-1 levels and breast cancer development in a cohort of Brazilian women [ 23 ] or women during early pregnancy [ 24 ]. Mammographic density is one of the strongest predictors of breast cancer development and may be associated with serum IGF-1 levels in premenopausal women.…”

Section: Introductionmentioning

confidence: 99%

The role of the insulin-like growth factor-1 system in breast cancer

2015

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IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.

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Evaluation of the insulin-like growth factors (IGF) IGF-I and IGF binding protein 3 in patients at high risk for breast cancer

Cited by 12 publications

References 25 publications

Increased Igf‐I/Igfbp‐3 Ratios in Postmenopausal Taiwanese with Breast Cancer, Irrespective of Er and Pr Statuses and Her2 Expression in a Case–Control Study

Increased Igf‐I/Igfbp‐3 Ratios in Postmenopausal Taiwanese with Breast Cancer, Irrespective of Er and Pr Statuses and Her2 Expression in a Case–Control Study

Insulin resistance and cancer: the role of insulin and IGFs

The role of the insulin-like growth factor-1 system in breast cancer

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