Evaluation of the mean platelet volume in children with familial Mediterranean fever

Arıca, Seçil; Özer, Cahit; Arıca, Vefik; Karakuş, Ali; Çelik, Tanju; Güneşaçar, Ramazan

doi:10.1007/s00296-011-2251-x

Cited by 40 publications

(29 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Usefulness of MPV in assessment of atherosclerotic risk in cases with FMF was also investigated. In accordance with our results, most of the studies found significantly higher MPV values in FMF patients and stated that FMF is associated with increased risk of atherosclerosis [6,9,10]. MPV values were found higher even in attack-free FMF cases.…”

Section: Discussionsupporting

confidence: 92%

“…Mean platelet volume (MPV) and epicardial adipose tissue (EAT) thickness are novel parameters used in prediction of the risk of atherosclerosis [3,6-8]. Albeit contradictory results have been reported, there are some studies investigating the usefulness of MPV in assessment of atherosclerotic risk in cases with FMF [6,9,10]. However, no study evaluating EAT thicknesses of FMF patients was reported so far.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

et al. 2015

View full text Add to dashboard Cite

BackgroundFamilial Mediterranean fever (FMF) is an inflammatory disease, which is suggested to be associated with increased risk of atherosclerosis. Epicardial adipose tissue (EAT) thickness and the mean platelet volume (MPV) are parameters used in prediction of atherosclerotic risk in various conditions. These parameters were evaluated in children with FMF and compared with healthy controls.MethodsForty-five patients with FMF and 54 age- and gender-matched healthy controls were assessed. Duration of symptoms, age at diagnosis, duration of delay in diagnosis, frequency and duration of FMF attacks, disease severity scores, response to colchicine therapy, MEditerraneanFeVer (MEFV) gene mutations, and MPV values were recorded. EAT thicknesses were measured by echocardiography.ResultsEpicardial adipose tissue thicknesses of the children with FMF were found to be significantly greater than that of controls (5.1 ± 1.4 vs. 4.5 ± 0.9 mm, p = 0.036). FMF patients had significantly higher MPV values compared with the controls (7.8 ± 1.1 vs. 7.3 ± 1.4 fl, p = 0.044). Age at diagnosis, duration of delay in diagnosis, and MPV values were found to be correlated with EAT thickness in the patient group (r = 0.49, p = 0.001 for the former parameters and r = 0.32, p = 0.04 for MPV).ConclusionEpicardial adipose tissue thickness and MPV values seem to be increased in children with FMF. These findings may indicate an increased risk of atherosclerosis in FMF patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Outcomes of clinical and subclinical inflammation are unclear during FMF attack and in the attack-free period. As in other clinical entities accompanied by inflammation, FMF patients are at an increased risk of atherosclerosis development [6,12,13]. …”

Section: Discussionmentioning

confidence: 99%

Usefulness of Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio for Evaluation of Children with Familial Mediterranean Fever

et al. 2014

View full text Add to dashboard Cite

BackgroundFamilial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of serositis, fever, and rash. Clinical and subclinical inflammatory processes may contribute to atherosclerosis in FMF patients, with mean platelet volume (MPV) as a potential indicator for atherosclerosis risk and neutrophil-to-lymphocyte ratio (NLR) as a marker for subclinical inflammation in these patients. In this study, we investigated whether MPV can be used as an indicator for atherosclerosis risk and if NLR is a marker for subclinical inflammation in FMF patients.Material/MethodsThe study consisted of 75 FMF patients in attack, 157 attack-free patients, and 77 healthy controls. White blood cell count neutrophil-to-lymphocyte ratio, platelet count, MPV, PDW C-reactive protein levels, and erythrocyte sedimentation rate were recorded.ResultsThere were no significant differences between attack, attack-free, and control groups in terms of mean MPV and PDW value. NLR value was higher in the attack group. NLR value was similar in attack-free and control groups.ConclusionsWe found that MPV and PDW values are similar in FMF patients and healthy controls. NLR was higher in FMF patients in the attack period. Therefore, our results suggest that MPV and PDW values do not predict atherosclerosis risk in pediatric FMF patients, and NLR may be an indicator for attack period but not attack-free period.

show abstract

“…22,23 Moreover, NLR and MPV had higher levels at the attack periods in familial Mediterranean fever patients. 24,25 High levels of MPV and NLR have been found as a predictor for gastrointestinal bleeding in the Henoch-Schonlein purpura. 26,27 Decreased MPV and NLR have been shown with the treatment of rheumatoid arthritis and ankylosing spondylitis.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

et al. 2017

View full text Add to dashboard Cite

Objectives: This study aims to evaluate the role of neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) as activation and inflammatory markers in systemic lupus erythematosus (SLE) patients with nephritis. Patients and methods: A total of 108 SLE patients (8 males, 100 females; mean age 35.3±10.2 years; range 16 to 64 years) including 78 patients with renal involvement (8 males, 70 females; mean age 33.9±10.6 years; range 16 to 64 years) (SLEn+ group) and 30 patients without renal involvement (30 females; mean age 39.1±8.2 years; range 22 to 55 years) (SLEn-group) were included in this retrospective study. All patients' clinical characteristics and laboratory data which include erythrocyte sedimentation rate, C-reactive protein, white blood counts, neutrophil counts, lymphocyte counts, platelet counts, and MPV levels were obtained from medical records. The laboratory data at the highest proteinuria periods of the patients with renal involvement were recorded. Results: Mean MPV (SLEn+ =9.1±2.2, SLEn-=7.9±1.2, p=0.001) and NLR (SLEn+ =5.9±5.9, SLEn-=2.6±2.5, p<0.001) values were significantly higher in lupus nephritis group. Besides, a positive correlation between NLR and C-reactive protein was found in lupus nephritis group (r=1.97, p=0.045). Based on receiver operating characteristic curve with area under the curve of 0.76, cutoff NLR value of 1.93 had 83% sensitivity and 54% specificity [95% confidence interval, 0.66-0.85] in differentiating SLE patients with or without nephritis. Conclusion: Neutrophil to lymphocyte ratio and MPV may be discriminative for lupus nephritis. Also, NLR may be a predictor of lupus nephritis. Both MPV and NLR values may be affected by a great number of factors; therefore, further prospective studies are needed to evaluate the use of these parameters in SLE.

show abstract

Evaluation of the mean platelet volume in children with familial Mediterranean fever

Cited by 40 publications

References 22 publications

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

Assessment of epicardial adipose tissue thickness and the mean platelet volume in children with familial Mediterranean fever

Usefulness of Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio for Evaluation of Children with Familial Mediterranean Fever

Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

Contact Info

Product

Resources

About