Evaluation of the mutagenic and genotoxic effects of the ALC67 thiazolidine compound in Salmonella strains and human lymphocytes in vitro

Abstract

<jats:p> ALC67 is an N-acylated thiazolidine compound with promising anticancer activity that led to the recent discovery of a series of 3-propionyl thiazolidine-4-carboxylic acid ethyl esters as a family of novel antiproliferative agents. Since the mutagenic and genotoxic properties of marketed anticancer molecules constitute a main issue to be addressed, this study focused on the analysis of the mutagenicity, antimutagenecity, and genotoxicity of this molecule. The mutagenicity and antimutagenicity of ALC67 were evaluated by Ames test performed on Salmonella TA98 and TA100 strains. The genotoxicity of this molecule was investigated in the chromosomal aberration assay on human lymphocytes. All results revealed that the analyzed structure is not mutagenic in the two Salmonella strains tested and was not genotoxic in human lymphocytes in vitro. On the other hand, it showed a weak antimutagenic effect in these two bacterial strains. The above results indicate that after performing some more mutagenicity assays using the other recommended strains, this compound can be safely used for the development of new structures exhibiting anticancer activities. </jats:p>

Piperazin halkası taşıyan benzotiyazol türevlerinin toksikolojik değerlendirilmesi

“…Many of the cytotoxic agents commonly used to treat cancer patients cause high levels of DNA damage which initiate cell cycle checkpoints, leading to cell cycle arrest and/or cell death (3). As designed for inducing considerable damage to genetic material in cancer cells, anticancer drugs have to be studied for their genotoxic effects on normal cells in order to estimate their relative potencies to promote the growth of secondary malignancies (4).…”

Modulating the antibacterial activity of gold nanoparticles by balancing their monodispersity and aggregation

“…Thus, new strategies that can simultaneously optimize the particle function and maintain an ideal monodispersity of the nanomaterials are highly desirable, particularly for biomedical applications. [14][15][16][17] L-thioproline (T) is not only an anti-tumor drug 18,19 but also a starting material for synthesizing pidotimod, an immunomodulator. [20][21][22][23][24] Thus, thioproline is an ideal candidate for activating gold nanomaterials since an essential requirement of antibiotics is that they are nontoxic to human cells.…”

“…L-thioproline (T) is not only an anti-tumor drug 18,19 but also a starting material for synthesizing pidotimod, an immunomodulator. 20–24 Thus, thioproline is an ideal candidate for activating gold nanomaterials since an essential requirement of antibiotics is that they are nontoxic to human cells.…”