Skin wounds on stretchable parts of the body including the elbows, knees, wrists, and nape usually undergo delayed and poor healing due to the interference of their frequent motion. Ordinary dressings that are not flexible enough face difficulty to promote wound healing due to the mismatching between the mechanics of the dressing materials and the wounds. In this study, an injectable, biocompatible, self‐healable, and conductive material poly(3,4‐ethylenedioxythiophene): poly(styrenesulfonate)/guar slime (PPGS) is developed for healing wounds with various kinds of movements. As a proof‐of‐principle assay, the healing effect of PPGS is explored on a skin wound model on the nape of rats that often experiences frequent movements. PPGS, which can be prepared within 1 min, successfully accelerates the healing of the wounds. The results suggest that PPGS has great potential in the fields of tissue engineering and biomedicine.
This study uses metal–organic frameworks (MOFs) alone without any added antibacterial ingredients as the nonantibiotic agent for photodynamic therapy (PDT) of chronic wounds infected by multidrug‐resistant (MDR) bacteria. Nanoparticles (NPs) of MOFs (PCN‐224) are incorporated with titanium through a facile cation exchange strategy. The obtained bimetallic PCN‐224(Zr/Ti) shows greatly enhanced photocatalytic performance for the generation of reactive oxygen species under visible light, which is responsible for the effective antibacterial activities. The PCN‐224(Zr/Ti) NPs are loaded onto lactic‐co‐glycolic acid nanofibers to prepare a wound dressing, which shows high biocompatibility and minimal cytotoxicity. The wound dressing is efficient for PDT‐based in vivo healing of the chronic wound infected by MDR bacteria. Most importantly, this work does not involve any additional antibacterial agents, which is facile, low cost, and in particular, greatly explores the potential of MOFs as a powerful nonantibiotic agent in PDT.
With
the widespread use of antibiotics, the number of complex infection
cases caused by unknown pathogens is increasing and novel antibiotics
with tunable antibacterial spectra and low toxicity are highly desirable.
Herein, we report that, by selecting thiol or amine, two groups with
different binding affinities with gold, as anchoring groups, phenylboronic
acid can be decorated on gold nanoparticles (AuNPs) with different
densities, which contributes to Gram-selective antibacterial activities
of the AuNPs. The AuNPs modified with amine- or thiol-tethered phenylboronic
acids specifically bind to lipopolysaccharide (LPS, Gram-negative)
or lipoteichoic acid (LTA, Gram-positive), respectively. By modifying
AuNPs with different ratios of thiol- and amine-tethered phenylboronic
acids, the resulting AuNPs show potent and tunable antibacterial activity.
The AuNP-based antibacterial agents with optional Gram selectivity
are promising for applications in personalized therapy.
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