Evaluation of the mutagenicity and antimutagenicity of forty-two 3-substituted flavones in the Ames test

Beudot, C.; Méo, M.P. De; Dauzonne, Daniel; Élias, Riad; Laget, M.; Guiraud, H.; Balansard, G.; Duménil, Gérard

doi:10.1016/s1383-5718(98)00103-x

Cited by 48 publications

(38 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The use of medicinal plants is a generalized practice in popular medicine for the treatment of different types of disease. However, not all species are harmless to human health, and may present toxic and mutagenic substances in their phytochemical composition Bresolin and Vargas, 1993;Beudot et al, 1998;Sá Ferreira and Vargas, 1999). On the other hand, a protective action of phytochemical compounds on genetic material has been reported, leading to its repair or to preserving its integrity (Imanishi et al, 1991;Chin Yen and Yin Chen, 1996).…”

Section: Introductionmentioning

confidence: 99%

Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa

Fernandes

Vargas

2003

Phytotherapy Research

View full text Add to dashboard Cite

Aqueous extracts of medicinal plants (Mikania laevigata and Campomanesia xanthocarpa) were screened for the presence of mutagenic activity in the Salmonella/microsome assay. The extracts of Campomanesia xanthocarpa showed frameshift (TA97a strain) signs of mutagenic activity without exogenous metabolism (S9 fraction). The infusions of Mikania laevigata, negative for mutagenic activity, showed high percentages of inhibition of mutagenesis induced by mutagens 2AF (2-amino fluorene), in the presence of exogenous metabolism (S9 fraction), for frameshift (TA98) and base pair substitution (TA100) lesions. In addition, these inhibitions were observed against mutagen SAZ (sodium azide) in assays with the TA100 strain, without exogenous metabolism (S9 fraction). A synergistic effect was also observed in frameshift mutagenic events, with direct action in the presence of 4NQO (4-oxide-1-nitroquinoline) and a tendency to a low percentage of action enhancement, in the presence of the 2AF mutagen. The variable responses observed in the extract assays show the potentials for interaction of the different active principles in genetic material.

show abstract

Section: Introductionmentioning

confidence: 99%

Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa

Fernandes

Vargas

2003

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…During this process, the transformation of promutagen into the mutagen takes place primarily by the action of phase I metabolic enzymes, such as the cytochrome P450. The mutagen activation involves N-oxidation by cytochrome P4501A2 followed by the activation by N-acetyltransferase [10]. Some common examples of direct and indirect acting mutagens with their possible mechanism of action have been documented in Tables 1 and 2.…”

Section: Mutagens and Their Typesmentioning

confidence: 99%

Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

View full text Add to dashboard Cite

Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

show abstract

“…The mutagenic and antimutagenic activities of forty-two synthetic flavones were evaluated via the Ames test by Beudot et al [38]. The tested flavones included twenty-three 3-nitroflavones, eighteen 3-aminoflavones and 3-chloroflavone.…”

Section: Applicationmentioning

confidence: 99%

“…It was found that the mutagenicity of the 3-aminoflavones required the presence of the metabolic activation. Meanwhile, the 3-amino derivatives were more mutagenic than the 3-nitro counterparts [38]. Total and fractionated organic extracts from industrial effluents and Labe river water were tested for mutagenicity effect using the Ames test with TA98 strain and its YG derivatives (YG1021, YG1024 and YG1041) and cytogenetic analysis with human peripheral lymphocytes in vitro.…”

Section: Applicationmentioning

confidence: 99%

Biological procedures to detect carcinogenic compounds in domestic wastewater

Malakahmad¹,

Manan²,

Hilmin³

2014

WIT Transactions on Ecology and the Environment

View full text Add to dashboard Cite

Cancer is a leading cause of death worldwide and can be increased further to more than 13.1 million people per year by 2030. Cancer occurs due to the continuous exposure of carcinogenic compounds under certain concentrations. A carcinogen is an agent that can cause mutation, leading to cancer. Therefore, mutations are indications of the presence of carcinogenic compounds. The mutation effects in biological organisms are various. They are chromosomal aberrations, growth inhibition and teratogenic effects. These effects can only be detected through the application of biological approaches. This review gives descriptions on the biological detection and measurement of carcinogens in wastewater and water estuaries. The biological procedures such as the chromosomal aberration (CA), Comet assay, Micronucleus (MN) assay SOS chromotest and organic extraction of XAD with blue rayon is discussed. These bioassays played an important role in the detection of carcinogens from waterborne contaminants in the environment such as pesticides, industrial pollution and heavy metals. The evaluations are based on advantages and disadvantages, accuracy, speed and time factor of methods and experimental procedures. As cancer is often linked to DNA damage, these assays are also time and cost effective to estimate the carcinogenic potential of a compound. Thus, the concept of carcinogenic compounds detection and measurement in wastewater is of great attention due to their toxic and non-biodegradable nature.

show abstract

Evaluation of the mutagenicity and antimutagenicity of forty-two 3-substituted flavones in the Ames test

Cited by 48 publications

References 38 publications

Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa

Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa

Fruits and Vegetables as Dietary Sources of Antimutagens

Biological procedures to detect carcinogenic compounds in domestic wastewater

Contact Info

Product

Resources

About