Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative

Sumanont, Yaowared; Murakami, Yukihisa; Tohda, Michihisa; Vajragupta, Opa; Matsumoto, Kinzo; Watanabe, Hiroshi

doi:10.1248/bpb.27.170

Cited by 129 publications

(95 citation statements)

References 22 publications

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“…Nitric oxide has many physiological functions including vasodilatation or synaptic plasticity in the central nervous system. On the other hand, the nitric oxide radical is implicated in pathogenesis of several diseases (Sumanont et al 2004). Nitric oxide belongs to reactive oxygen species (ROS) including free radicals such as superoxide anion (O 2 -) and hydroxyl radical species (OH•) (Wang et al 2009).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit

Rop¹,

Řezníček²,

Mlček³

et al. 2011

Hortic. Sci.

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Rop O., Řezníček V., Mlček J., Juríková T., Balík J., Sochor J., Kramářová D., 2011. Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit. Hort. Sci. (Prague), 38: 63-70.The fruit of blue honeysuckle (Lonicera caerulea L. var. kamtchatica (Sevast.) Pojark.) belongs to the fruit of great value because of itsunique chemical composition. The aim of our measurement of this fruit species was to select the cultivars which could be the most suitable food supplement in relation to strengthening human immunity system. The comparison of the fruit of 12 cultivars was made. The highest contents of polyphenolic substances were recorded in the cultivar Zolushka with the value of 9.03 g of gallic acid/kg fresh mass. In particular cultivars the DPPH (2,2-diphenyl-1-picrylhydrazyl) test was performed to determine antioxidant activity which ranged from 6.59-10.17 g of ascorbic acid equivalent/kg fresh mass. For comparison, scavenging activity of reactive oxygen species (superoxide anion, hydroxyl radical, and nitric oxide) was determined by using a 25% methanolic extract of fruit of particular cultivars. Antioxidant potential was also assessed using the rat liver slice model. The highest values of scavenging activity were found in the cultivars Zolushka, Goluboe vreteno, and Gerda. The cultivars Zolushka, Goluboe vreteno, and Gerda had also high values of flavonoids. The presented results may be used when popularizing this fruit species and also when studying the properties of new food and genetic resources.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit

Rop¹,

Řezníček²,

Mlček³

et al. 2011

Hortic. Sci.

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“…This NO can be oxidized quickly to produce a nitrite ion that can be detected with the Griess reagent [21] . The SNP powder was dissolved in phosphatebuffered saline (PBS), pH 7.4, to a concentration of 100 mmol/L.…”

Section: Nitric Oxide (No) Determinationmentioning

confidence: 99%

Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophages

Pang

Liu

2009

Acta Pharmacol Sin

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Aim:The aim of this study was to investigate the effect of the squamosamide derivative FLZ (N-2-(4-hydroxy-phenyl)-ethyl-2-(2,5-dimethoxy-phenyl)-3-(3-methoxy-4-hydroxy-phenyl)-acrylamide) on lipopolysaccharide (LPS)-induced inflammatory mediator production and the underlying mechanism in RAW264.7 macrophages. Methods: RAW264.7 cells were preincubated with non-toxic concentrations of compound FLZ (1, 5, and 10 µmol/L) for 30 min and then stimulated with 10 μg/L LPS. The production of nitric oxide (NO), the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), and the activation of nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways were examined. Results: FLZ significantly inhibited the LPS-induced production of NO, as well as the expression of iNOS and COX-2 at both the RNA and the protein levels in RAW264.7 cells. The LPS-induced increase in the DNA binding activity of NF-κB and activator protein 1 (AP-1), the nuclear translocation of NF-κB p65, the degradation of the inhibitory κBα protein (IκBα) and the phosphorylation of IκBα, IκB kinase (IKK) α/β, c-Jun NH 2 -terminal kinase (JNK) and p38 MAPKs were all suppressed by FLZ. However, the phosphorylation of extracellular signal-regulated kinase (ERK) was not affected. Further study revealed that FLZ inhibited the phosphorylation of transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1), which is an upstream signaling molecule required for IKKα/β, JNK and p38 activation. Conclusion: FLZ inhibited the LPS-induced production of inflammatory mediators at least partly through the downregulation of the TAK-IKK and TAK-JNK/p38MAPK pathways.

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“…The inhibition of cancer cell invasion by bDMC highlights its enhanced A c c e p t e d M a n u s c r i p t 4 antimetastasis potency [26]. The synthetic derivative DAC shows higher antibacterial activity against multiresistant bacteria [27] and a stronger nitric oxide (NO) and O 2 •-anion scavenging activity [28,29], although it has slightly lower apoptotic activity on AK-5 rat histiocytoma cells [30].…”

Section: Introductionmentioning

confidence: 99%

Curcumin derivatives: Molecular basis of their anti-cancer activity

Basile

Ferrari

Lazzari

et al. 2009

Biochemical Pharmacology

169

129

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Curcumin, a phenolic compound from the plant Curcuma longa L., has shown a wide-spectrum of chemopreventive, anti-oxidant and anti-tumor properties. Although its promising chemotherapeutic activity, preclinical and clinical studies highlight Curcumin limited therapeutic application due to its instability in physiological conditions. To improve its stability and activity, many derivatives have been synthesized and studied, among which bis-DemethoxyCurcumin (bDMC) and diAcetylCurcumin (DAC). In this report, we show that both bDMC and DAC are more stable than Curcumin in physiological medium. To explore the mechanism of their chemotherapeutic effect, we studied their role in proliferation in the HCT116 human colon cancer cells. We correlated kinetic stability and cellular uptake data to their biological effects. Both bDMC and DAC impair correct spindles formation and induce a p53-and p21 CIP1/WAF1 -independent mitotic arrest, which is more stable and long-lasting for bDMC. A subsequent p53/p21 CIP1/WAF1 -dependent inhibition of G1 to S transition is triggered by Curcumin and DAC as a consequence of the mitotic slippage, preventing postmitotic cells from re-entering the cell cycle. Conversely, the G1/S arrest induced by bDMC is a direct effect of the drug and concomitant to the mitotic block. Finally, we demonstrate that bDMC induces rapid DNA double-strand breaks, moving for its possible development in anti-cancer clinical applications.

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Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative

Cited by 129 publications

References 22 publications

Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit

Antioxidant and radical oxygen species scavenging activities of 12 cultivars of blue honeysuckle fruit

Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophages

Curcumin derivatives: Molecular basis of their anti-cancer activity

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