Evaluation of the nutraceutical, antioxidant and cytoprotective properties of ripe pistachio ( Pistacia vera L., variety Bronte) hulls

Barreca, Davide; Laganà, Giuseppina; Leuzzi, Ugo; Smeriglio, Antonella; Trombetta, Domenico; Bellocco, Ersilia

doi:10.1016/j.foodchem.2015.09.077

Cited by 152 publications

(117 citation statements)

References 42 publications

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“…The amount of carotenoids, anthocyanins, and glutathione, and also a high ascorbic acid content with respect to the dehydroascorbic acid concentration (Table 2), indicate how the plant has developed its antioxidative defense system in the acclimation process for controlling ROS homeostasis. Plant phenolics constitute one of major groups of compounds acting as primary antioxidant or free radical terminators [32,36,37,38,39,40,41,42,43,44,45,46]. The leaf extracts of Jatropha curcas L. are also rich in phenolic compounds and tartaric acid ester derivatives (Table 2), which further contribute to the health promoting properties of this plant.…”

Section: Resultsmentioning

confidence: 99%

“…Hemolysates were prepared according to Barreca et al [38] and lipid peroxidation was analyzed by thiobarbituric acid reactive substance (TBARS) assay [74]. …”

Section: Methodsmentioning

confidence: 99%

“…Moreover, in all experiments blanks, without t-BOOH, were performed [38,75]. The cell viability, after finishing the incubation period were established with trypan blue staining.…”

Section: Methodsmentioning

confidence: 99%

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Assessment of Antioxidant and Cytoprotective Potential of Jatropha (Jatropha curcas) Grown in Southern Italy

Papalia

Barreca

Panuccio

2017

IJMS

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Jatropha (Jatropha curcas L.) is a plant native of Central and South America, but widely distributed in the wild or semi-cultivated areas in Africa, India, and South East Asia. Although studies are available in literature on the polyphenolic content and bioactivity of Jatropha curcas L., no information is currently available on plants grown in pedoclimatic and soil conditions different from the autochthon regions. The aim of the present work was to characterize the antioxidant system developed by the plant under a new growing condition and to evaluate the polyphenol amount in a methanolic extract of leaves. Along with these analyses we have also tested the antioxidant and cytoprotective activities on lymphocytes. RP-HPLC-DAD analysis of flavonoids revealed a chromatographic profile dominated by the presence of flavone C-glucosydes. Vitexin is the most abundant identified compound followed by vicenin-2, stellarin-2, rhoifolin, and traces of isovitexin and isorhoifolin. Methanolic extract had high scavenging activity in all antioxidant assays tested and cytoprotective activity on lymphocytes exposed to tertz-buthylhydroperoxide. The results highlighted a well-defined mechanism of adaptation of the plant and a significant content of secondary metabolites with antioxidant properties, which are of interest for their potential uses, especially as a rich source of biologically active products.

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Section: Resultsmentioning

confidence: 99%

“…Hemolysates were prepared according to Barreca et al [38] and lipid peroxidation was analyzed by thiobarbituric acid reactive substance (TBARS) assay [74]. …”

Section: Methodsmentioning

confidence: 99%

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Assessment of Antioxidant and Cytoprotective Potential of Jatropha (Jatropha curcas) Grown in Southern Italy

Papalia

Barreca

Panuccio

2017

IJMS

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“…The same was found for cytoprotective activity on lymphocytes, lipid peroxidation and protein degradation. Their findings highlight the strong antioxidant and cytoprotective activity of the extract components [21], the methanol extract having a 1.7-fold higher phenolic content than that of ethanol. In our results ethyl acetate extracts have more cytotoxic effect and maybe the anticancer mechanism is more related to antiangiogenesis than antioxidant effects.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Effects and Anti-Angiogenesis Potential of Pistachio (Pistacia vera L.) Hulls against MCF-7 Human Breast Cancer Cells

et al. 2018

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Pistachio (Pistacia vera L.) hulls (PVLH) represents a significant by-product of industrial pistachio processing that contains high amounta of phenolic and flavonoid compounds known to act as antioxidants. The current study was designed to evaluate the anti-tumor and anti-angiogenic potentials of PVLH extracts. The cytotoxic effects of hexane, ethyl acetate, methanol, and water PVLH extracts toward human colon cancer (HT-29 and HCT-116), breast adenocarcinoma (MCF-7), lung adenocarcinoma (H23), liver hepatocellular carcinoma (HepG2), cervical cancer (Ca Ski), and normal fibroblast (BJ-5ta) cells were assessed using a MTT cell viability assay. Apoptosis induction was evaluated through the different nuclear staining assays and confirmed by flow cytometry analysis. Anti-angiogenic activities were also determined using chorioallantoic membrane (CAM) assay. PVLH ethyl acetate extracts (PVLH-EAE) demonstrated a suppressive effect with an IC50 value of 21.20 ± 1.35, 23.00 ± 1.2 and 25.15 ± 1.85 µg/mL against MCF-7, HT-29 and HCT-116, respectively, after 72 h of treatment. Morphological assessment and flow cytometry analysis showed the potential of PVLH-EAE to induce apoptosis. PVLH-EAE at the highest concentration demonstrated significant inhibition of angiogenesis as comparing with control group. Also the expression of Bax increased and the expression of Bcl-2 decreased in treated MCF-7 cells. Thus, the apoptosis induction and angiogenesis potential of PVLH-EAE make it to be the most suitable for further cancer research study to deal with selective antitumor active substances to human cancers especially breast cancer.

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“…Different compounds including procyanidin, neoflavone, penta- and tetra-cyclic triterpens, α-β pinene, oleanonic acid, lanostane, and flavonoids have been found in pistachio (10). Flavonoids are phytoestrogens in plants like pistachio especially in its hull (11) had been the focus of intense research for their biological activities.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic-like effect of hydroalcoholic extract of ripe pistachio hulls in adult female Wistar rats and its possible mechanisms

et al. 2016

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The present study was designed to study the preventive effect of hydroalcoholic extract of ripe pistachio hulls (RPH) in the elevated plus maze model of anxiety. One hundred twenty female wistar rats in their estrous cycle were divided into 15 groups of 8 each and received various concentrations of hydroalcoholic extract of RPH except the control groups. Elevated plus maze was used to measure the level of anxiety. Percentage of time spent in the open arms (%OAT), percentage of the number of entries into the open arms (%OAE), locomotor activity, and time spent in the closed arms (CAT), and the number of entries in to the closed arms (CAE) were measured and compared. Dose-response experiments showed that only 10 mg/kg dose of RPH extract significantly increased %OAT (P < 0.001) and %OAE (P < 0.05) compared to the control group, indicating anti-anxiety effects of the extract. Also, pentylenetetrazol and an estrogen receptor antagonist (ERA) tamoxifen could block anti-anxiety effects of the extract (P < 0.001). It was also noticed that tamoxifen was able to significantly reduce locomotor activity. As the RPH extract showed a preventive effect in experimental model of anxiety, it might be concomitantly administered with other anxiolytic medications.

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Evaluation of the nutraceutical, antioxidant and cytoprotective properties of ripe pistachio ( Pistacia vera L., variety Bronte) hulls

Cited by 152 publications

References 42 publications

Assessment of Antioxidant and Cytoprotective Potential of Jatropha (Jatropha curcas) Grown in Southern Italy

Assessment of Antioxidant and Cytoprotective Potential of Jatropha (Jatropha curcas) Grown in Southern Italy

Cytotoxic Effects and Anti-Angiogenesis Potential of Pistachio (Pistacia vera L.) Hulls against MCF-7 Human Breast Cancer Cells

Anxiolytic-like effect of hydroalcoholic extract of ripe pistachio hulls in adult female Wistar rats and its possible mechanisms

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