Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice

Zia, Tayyaba; Hasnain, S. N.; Hasan, Syed Kazim

doi:10.1016/s0378-8741(01)00186-6

Cited by 143 publications

(77 citation statements)

References 17 publications

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“…The whole powder of fenugreek seeds and its methanol extract showed a significant hypoglycemic activity, when fed simultaneously with glucose to rats (Ali et al, 1995). The seed fiber of fenugreek reduces the rate of glucose absorption from gastro-intestinal tract and delay gastric emptying; thereby preventing hyperglycemia after meal (Gupta et al, 2001), in addition, aqueous seed extract also showed a significant fall in blood glucose in normoglycaemic mice (Zia et al, 2001). Thus, fenugreek seeds may be useful as a functional food with therapeutic value.…”

Section: Introductionmentioning

confidence: 99%

Hydroalcohol extract ofTrigonella foenum-graecumseed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats

Joshi¹,

Patil²,

Naik³

2014

Pharmaceutical Biology

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Context and objective: The herb fenugreek, Trigonella foenum-graecum Linn (Fabaceae), seeds have been traditionally used in the treatment of diabetes but its effect on oxidative stress and pro-inflammatory cytokines in the improvement of exocrine function of diabetes has not been studied. The effect of hydroalcoholic extract of Trigonella foenum-graecum seeds (HEF) on alloxan-induced type-II diabetic rat model was investigated. Materials and methods: Effect of HEF (500, 1000, and 2000 mg/kg), glimepiride (4 mg/kg), and combination of HEF (500 mg/kg) + glimepiride (2 mg/kg), on alloxan-induced diabetic rats was evaluated by assaying (blood glucose, serum protein, glycosylated hemoglobin, muscle and liver glycogen, glucose uptake by diaphragm, liver glucose transport, serum pancreatic enzymes (a-amylase, lipase), pro-inflammatory cytokines (TNF-a, IL-6), antioxidant enzymes [glutathione (GSH), superoxide dismutase (SOD)], lipid peroxides (liver and pancreas), and histoarchitecture (liver, pancreas). Results: Treatment with HEF (at different doses), glimepiride, and HEF + glimepiride increased body weight and glucose uptake, reduced plasma glucose, glycosylated hemoglobin, liver glucose transport, pro-inflammatory cytokines, pancreatic enzymes and restored depleted glycogen (muscle, liver) and total protein significantly (p50.01) and dose dependently, including prevention of lipid peroxidation and restoration of GSH and SOD (liver and pancreas). Treatment with HEF + glimepiride potentiated hypoglycemic activity of glimepiride. Histoarchitecture of liver and pancreas showed marked improvement. Conclusion: Present experimental findings suggest that HEF possesses promising hypoglycemic activity, presumably by amelioration of oxidative stress and pro-inflammatory cytokines. HEF may be useful as an adjuvant with clinically effective antidiabetic drugs in the management of type-II diabetes.

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Section: Introductionmentioning

confidence: 99%

Hydroalcohol extract ofTrigonella foenum-graecumseed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats

Joshi¹,

Patil²,

Naik³

2014

Pharmaceutical Biology

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“…Fenugreek (Trigonella foenum-graecum L., Leguminosae), one of the oldest medicinal plants, is of Mediterranean origin and cultivated worldwide. Aqueous extracts of seeds and leaves of fenugreek have been shown to possess hypoglycaemic activity and are nontoxic (Abdel-Barry et al, 1997;Zia et al, 2001;Vats et al, 2002;Basch et al, 2003), but no detailed study to elucidate the mechanism of action of these extracts at the cellular and molecular level has been performed. Hence, in the present study, a dialysed aqueous extract of fenugreek seeds was investigated in vivo for hypoglycaemic potential and its effects on insulin signalling pathways in the primary targets of insulin, adipocytes and liver cells, were examined in vitro, by the use of mechanism-based innovative contemporary strategies.…”

Section: Introductionmentioning

confidence: 99%

The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway

Vijayakumar

Singh

Chhipa

et al. 2005

British J Pharmacology

134

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1 The in vivo hypoglycaemic activity of a dialysed fenugreek seed extract (FSE) was studied in alloxan (AXN)-induced diabetic mice and found to be comparable to that of insulin (1.5 U kg À1). FSE also improved intraperitoneal glucose tolerance in normal mice. 2 The mechanism by which FSE attenuated hyperglycaemia was investigated in vitro. FSE stimulated glucose uptake in CHO-HIRc-mycGLUT4eGFP cells in a dose-dependent manner. This effect was shown to be mediated by the translocation of glucose transporter 4 (GLUT4) from the intracellular space to the plasma membrane. 3 These effects of FSE on GLUT4 translocation and glucose uptake were inhibited by wortmannin, a phosphatidylinositol 3-kinase (PI3-K) inhibitor, and bisindolylmaleimide 1, a protein kinase C (PKC)-specific inhibitor. 4 In vitro phosphorylation analysis revealed that, like insulin, FSE also induces tyrosine phosphorylation of a number of proteins including the insulin receptor, insulin receptor substrate 1 and p85 subunit of PI3-K, in both 3T3-L1 adipocytes and human hepatoma cells, HepG2. However, unlike insulin, FSE had no effect on protein kinase B (Akt) activation. 5 These results suggest that in vivo the hypoglycaemic effect of FSE is mediated, at least in part, by the activation of an insulin signalling pathway in adipocytes and liver cells.

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“…Weight gain and hypoglycemia are common side effect of insulin. [32][33][34] Vigorous insulin treatment may also carry an increase in atherogenesis. [33] The average fasting sugar amongst patients is seen to be 8.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Liver Function Test Associated Amongst Diabetes Patients in the Dhaka City of Bangladesh.

Reyad‐ul‐Ferdous¹

2017

WJPR

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Objective: In recent era diabetics becomes most pathological condition worldwide. Maximum populations in both develop and developing countries suffering from diabetic. There are several diseases associated with diabetics like as kidney, liver, heart diseases etc. Methods: In this study, retrospectively study conducted at BUSB.Then data were entered into computer and results were calculated with the help of Microsoft Excel. Results: In the study, it has been found that the percentage of female is found to be 53% with diabetes and the percentage of male is found to be 46%.The level of Serum glutamic pyruvic transaminase (SGPT) also called (Alanin Transaminase) is found to be relatively high amongst the diabetes patient who reflects that the liver problems are prominent amongst diabetes patients. The average value of alanine transaminase which is released from liver is found to be 47.41+2.37 IU/L. Mean level of creatnine is found to be 0.93+0.022 mL/min (Normal range: 0.4to1.2 mL/min). HbA1c is amount of glycated hemoglobin is a form of hemoglobin that is measured primarily to identify the average plasma glucose concentration over prolonged periods of time. The average HbA1c is found to be 10.81865 + 2.126 mmol/mol. Lipid profiles are other important parameter which is play vital role amongst the health of diabetes patients. The

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Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice

Cited by 143 publications

References 17 publications

Hydroalcohol extract ofTrigonella foenum-graecumseed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats

Hydroalcohol extract ofTrigonella foenum-graecumseed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats

The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway

Abnormal Liver Function Test Associated Amongst Diabetes Patients in the Dhaka City of Bangladesh.

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