Evaluation of the penetration of nanocrystalline silver through various wound dressing mediums: An in vitro study

Potgieter, Magnus D.; Meidany, Parastu

doi:10.1016/j.burns.2017.10.011

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Acticoat is a nanocrystalline silver dressing that acts as an antimicrobial topical, releasing silver into the wound. This nanoformulation has been shown to inhibit in vitro biofilms formation in P. aeruginosa and Acinetobacter baumannii by more than 90% (Potgieter and Meidany, 2017 ). Madigan Army Medical Center is studying the efficacy of a silver NPs gel SilvaSorb (NCT00659204) and currently is in phase III of the clinical trials.…”

Section: Clinical Translationmentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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Infectious diseases remain one of the leading causes of morbidity and mortality worldwide. The WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria. Therefore, the antibiotic resistance crisis is one of the most pressing issues in global public health. Associated with the rise in antibiotic resistance is the lack of new antimicrobials. This has triggered initiatives worldwide to develop novel and more effective antimicrobial compounds as well as to develop novel delivery and targeting strategies. Bacteria have developed many ways by which they become resistant to antimicrobials. Among those are enzyme inactivation, decreased cell permeability, target protection, target overproduction, altered target site/enzyme, increased efflux due to over-expression of efflux pumps, among others. Other more complex phenotypes, such as biofilm formation and quorum sensing do not appear as a result of the exposure of bacteria to antibiotics although, it is known that biofilm formation can be induced by antibiotics. These phenotypes are related to tolerance to antibiotics in bacteria. Different strategies, such as the use of nanostructured materials, are being developed to overcome these and other types of resistance. Nanostructured materials can be used to convey antimicrobials, to assist in the delivery of novel drugs or ultimately, possess antimicrobial activity by themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug resistance mechanisms in bacteria and, associated with their antimicrobial potential, inhibit biofilm formation or other important processes. Other strategies, including the combined use of plant-based antimicrobials and nanoparticles to overcome toxicity issues, are also being investigated. Coupling nanoparticles and natural-based antimicrobials (or other repurposed compounds) to inhibit the activity of bacterial efflux pumps; formation of biofilms; interference of quorum sensing; and possibly plasmid curing, are just some of the strategies to combat multidrug resistant bacteria. However, the use of nanoparticles still presents a challenge to therapy and much more research is needed in order to overcome this. In this review, we will summarize the current research on nanoparticles and other nanomaterials and how these are or can be applied in the future to fight multidrug resistant bacteria.

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Section: Clinical Translationmentioning

confidence: 99%

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

McCusker²,

et al. 2018

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“…When in contact with bodily fluids and intravenous solutions, AgTive® releases silver ions to reduce bloodstreamborne infections. Similarly, Acticoat™ is a nanocrystalline silver wound covering that offers a powerful antimicrobial barrier to a broad spectrum of wound microorganisms [146][147][148]. This nano-formulation has been demonstrated to inhibit biofilm development in A. baumannii (Acinetobacter baumannii) and P. aeruginosa models by more than 90%.…”

Section: Metallic Nanoparticle-based Antimicrobial Strategiesmentioning

confidence: 99%

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

Jiang¹,

Ding²,

Liu³

2023

Theranostics

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Pathogenic bacterial infections represent an ever-growing crisis, now significantly threatening life expectancy across the worldwide population and thus novel approaches to tackle this issue are urgently needed. The application of nanotechnology in recent years has opened up new horizons in the selective or specific delivery of drugs or imaging agents to infectious sites. In particular, the development of nanoparticles for both delivery of active substances and imaging of infection sites is now gathering much interest. Although still in its infancy, the field of antibacterial nanomedicines provides exciting new possibilities to combat multi-resistant bacterial infections and shows great promise for personalized medicine in antibacterial stewardship. This review examines nanoparticle-based formulations used for therapeutic delivery, pathogen tracking in diagnosis, and combined “theranostic” approaches to more effectively treating bacterial infections.

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“…With the development of nanotechnology, many studies have shown that silver nanoparticles exhibit prolonged and controlled release of silver ions; this can improve biological safety and reduce the frequency of clinical dressing replacements required with the use of silver salts [87]. Silver nanoparticles have strong bactericidal properties that have been observed in both in vivo and in vitro experiments [88][89][90][91]. More importantly, silver is a broad-spectrum antibiotic that is active against fungi and bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).…”

Section: Cs-metal Nanocompositesmentioning

confidence: 99%

Recent Advances in Chitosan‐Based Metal Nanocomposites for Wound Healing Applications

Wang

et al. 2020

Advances in Materials Science and Engineering

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Chitosan (CS) has been extensively studied as a natural polymer, in the field of wound repair, due to its useful properties, which include a lack of toxicity and stimulation, excellent biological affinity, degradability, and promotion of collagen deposition. However, inferior mechanical strength and moderate antibacterial properties are the drawbacks restricting its further clinical application. Many researchers have adopted the use of nanotechnology, in particular metallic nanoparticles (MNPs), in order to improve the mechanical strength and specific antibacterial properties of chitosan composites, with promising results. Furthermore, chitosan naturally functions as a reducing agent for MNPs, which can also reduce cytotoxicity. Thus, CS, in combination with MNPs, exhibits antibacterial activity, excellent mechanical strength, and anti-inflammatory properties, and it has great potential to accelerate the process of wound healing. This review discusses the current use of CS and MNPs in wound healing and emphasises the synergy and the advantages for various applications in wound healing.

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Evaluation of the penetration of nanocrystalline silver through various wound dressing mediums: An in vitro study

Cited by 5 publications

References 7 publications

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections

Recent Advances in Chitosan‐Based Metal Nanocomposites for Wound Healing Applications

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