Evaluation of the Performance Characteristics of Bilayer Tablets: Part II. Impact of Environmental Conditions on the Strength of Bilayer Tablets

Kottala, Niranjan; Abebe, Admassu; Sprockel, Omar; Bergum, James; Nikfar, Faranak; Cuitiño, Alberto M.

doi:10.1208/s12249-012-9846-8

Cited by 13 publications

(5 citation statements)

References 13 publications

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“…Formulations L4, L5, and L6 containing 5, 3, and 2% CC‐Na showed 98.6% drug release within 40, 50, and 60 min, respectively, which may be due to rapid water uptake and strong swelling of disintegrating substance. During the development of bilayer tablets, the formulations containing low percentage of CC‐Na showed an increase in disintegration time . Formulation L4 containing 5% CC‐Na showed 98.6% drug release in 40 min and was predicted during formulation of bilayer tablet.…”

Section: Discussionmentioning

confidence: 92%

“…A friabilator was operated at 25 rpm for 4 min, and tablets were dropped at a distance of 6 inches with each tablet rotating at 100 revolutions, after which tablets were again dusted and weighted. The percentage of weight loss was calculated using the following formula:

Friability (%) = (\frac{W_{1} - W_{2}}{W_{1}}) \times 100

where W 1 is the initial weight and W 2 is the final weight.…”

Section: Methodsmentioning

confidence: 99%

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Design and Evaluation of Bilayer Matrix Tablet of Metoprolol Tartrate and Lisinopril Maleate

et al. 2015

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The objective of study was to design bilayer matrix tablet of metoprolol tartrate and lisinopril maleate. The direct compression method was used for preparation of both layers. Precompression and postcompression parameters were evaluated. USP Type II dissolution apparatus was used for the in vitro drug release study using 0.1 N HCl for immediate release of lisinopril maleate layer for 2 h and phosphate buffer at pH 6.8 for 10 h for metoprolol tartrate sustained layer. In vitro data were fitted into various kinetic models. Precompression parameters showed good flow properties of powder blend. Postcompression parameters were within compendia range. L7 (2% SSG and 3% CC-Na) was selected for formulation of immediate release layer that showed 91.6% drug release after 10 min, and for sustained release formulation, M4 (9% pectin, 9% acacia, and 20% Eudragit L100) showed 92.5% drug release for 10 h. Most formulations of sustained layer followed Higuchi drug release kinetics. Bilayer matrix tablet of metoprolol tartrate and lisinopril maleate can be formulated for the treatment of postmyocardial infarction. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 201 , , 21582; View this article online at wileyonlinelibrary.com.

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Section: Discussionmentioning

confidence: 92%

Friability (%) = (\frac{W_{1} - W_{2}}{W_{1}}) \times 100

where W 1 is the initial weight and W 2 is the final weight.…”

Section: Methodsmentioning

confidence: 99%

Design and Evaluation of Bilayer Matrix Tablet of Metoprolol Tartrate and Lisinopril Maleate

et al. 2015

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“…Because it may affect quality qualities including tensile strength, layer adhesion, friability, and dissolution, the physical stability of bilayer tablets during storage is an important consideration. As humidity and storage duration increased, the tablet's interfacial strength declined [5,6]…”

Section: Environmental Conditionsmentioning

confidence: 99%

Bilayer tablet overview: A revolutionary approach in sustained drug release & combination drug therapy

Inamdar,

Iftequar Ahmed

2024

JIPBS

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A fresh method of administering drug, the bilayer tablet is a single dosage form containing 2 or more Active Pharmaceutical Ingredients (API).By incorporating two distinct layers, bilayer tablets provide improved drug release profiles and enhanced therapeutic efficacy. This review's objective is to pinpoint the challengesthat arise when making bilayer tablets and to suggest solutions for these difficulties. To help you better grasp bilayer tablets, types like double side presses, single side presses, and bilayer tablet displacement presses are discussed along with their uses, advantages, and disadvantages.In this thorough guide, we will look into the design, manufacturing, and applications of bilayer tablets

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“…The amount of dissolved metronidazole was determined from UV absorbance at the wave length of maximum absorbance at 322 nm of filtered portion of the solution under test 12 . The release pattern was evaluated and was fit into varying kinetic models to further explain the release mechanism of the formulated tablets.…”

Section: Dissolution Rate Of Metronidazole and Metronidazole/activatementioning

confidence: 99%

“…The bilayered tablet concept is equally useful in drugs which require synergy to elicit profound pharmacological action. 11,12 In this present study bilayered tablets of metronidazole and activated charcoal and metronidazole tablets formulated via direct compression using xanthan gum as hydrophilic polymer were designed and evaluated comparing the physicochemical characteristics, drug release profile and release kinetic of all the formulations.…”

mentioning

confidence: 99%

Untitled

2017

IJPSR

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Background: Due to Escherichia coli O157:H7 bacteria's peculiar biochemical characteristics it is considered an emerging pathogen. The aim of this study is to design, develop and evaluate the efficacy of a single formulation combining adsorptive and anti infective properties in the treatment of diarrhoea caused by Escherichia coli O157:H7 in an animal model. Method: A bilayered tablet of metronidazole and activated charcoal (AC) formulated via direct compression was developed using hydrophilic mucoadhesive polymer xanthan gum in varying concentrations to ensure modified release of metronidazole in the first layer and activated charcoal with microcrystalline cellulose for instant disintegration in the second layer. Escherichia coli infected Sprague Dawley ® rats was utilized to evaluate the efficacy of the formulation. Results: Swelling studies reflected an affinity for the polymer to swell in pH 6.8 where drug release and swelling was influenced by ionic strength of the medium owing to the conformational changes in the xanthan gum in this media with an increase in the zeta charge from-28.5 mV to-40.2 mV, drug release being predominantly by zero order. Treatment with activated charcoal and metronidazole reflected a negative result for identification of Escherichia coli O157:H7 by the third day of treatment in stool with symptoms cessation occurring by the second day of treatment. Conclusion: The synergistic potential of a nitro-imidazole and an adsorbent has been evaluated and established with treated groups showing cessation of symptoms within twenty four hours thus effective in the treatment of Escherichia coli O157:H7 associated diarrhea. INTRODUCTION: Metronidazole a nitro imidazole derivative is a commonly used antibiotic in the treatment of anaerobic infections associated with diarrheal disease as well as clostridium difficile infections. 1

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Evaluation of the Performance Characteristics of Bilayer Tablets: Part II. Impact of Environmental Conditions on the Strength of Bilayer Tablets

Cited by 13 publications

References 13 publications

Design and Evaluation of Bilayer Matrix Tablet of Metoprolol Tartrate and Lisinopril Maleate

Design and Evaluation of Bilayer Matrix Tablet of Metoprolol Tartrate and Lisinopril Maleate

Bilayer tablet overview: A revolutionary approach in sustained drug release & combination drug therapy

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