Evaluation of the photosensitizing properties of zinc and indium tetra cinnamic acid phthalocyanines linked to magnetic nanoparticles on human breast adenocarcinoma cells

Matlou, Gauta Gold; Oluwole, David O.; Nyokong, Tebello

doi:10.1016/j.jlumin.2018.09.054

Cited by 13 publications

(7 citation statements)

References 36 publications

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“…Perkoic et al synthesized harmicine and cinnamic acid hybrids (35)(36)(37) (Figure 8). In vitro cytotoxicity of the hybrids on a human liver hepatocellular carcinoma cell line (HepG2) depended on the harmicine type and substituent in the cinnamic acid derivative.…”

Section: Cinnamic Acid Derivatives With Anticancer Activitymentioning

confidence: 99%

“…Matlou et al synthesized zinc and indium tetra cinnamic acid phthalocyanine (Pc) complexes (38)(39)(40) (Figure 9) which were covalently linked through an amide bond to amino-functionalized magnetic nanoparticles (AMNPs) [35]. Cinnamic acid was connected to the nanoparticles due to its antitumor activity [36].…”

Section: Cinnamic Acid Derivatives With Anticancer Activitymentioning

confidence: 99%

“…PDT activity decreased for compounds 39a-c since phthalocyanine photoactivity decreased upon linking to AMNPs due to phthalocyanine complex aggregation. Compound 38b outperformed 38a and 38c due to spin-orbit coupling and efficient transfer of energy to ground state molecular oxygen, which gives it the significant cytocidal activity against the tumorigenic cells [35].…”

Section: Cinnamic Acid Derivatives With Anticancer Activitymentioning

confidence: 99%

“…Chemical structures of zinc and indium tetra cinnamic acid phthalocyanine (Pc) complexes covalently linked to amino-functionalized magnetic nanoparticles (AMNPs)[35].…”

mentioning

confidence: 99%

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Cinnamic Acid Derivatives and Their Biological Efficacy

Ruwizhi

Aderibigbe

2020

IJMS

279

134

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological efficacy of the synthesized cinnamic acid derivatives. Some of the derivatives have been reported to be more effective when compared to the standard drugs used to treat chronic or infectious diseases in vitro, thus making them very promising therapeutic agents. Compound 20 displayed potent anti-TB activity, compound 27 exhibited significant antibacterial activity on S. aureus strain of bacteria and compounds with potent antimalarial activity are 35a, 35g, 35i, 36i, and 36b. Furthermore, compounds 43d, 44o, 55g–55p, 59e, 59g displayed potent anticancer activity and compounds 86f–h were active against both hAChE and hBuChE. This review will expound on the recent advances on cinnamic acid derivatives and their biological efficacy.

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Section: Cinnamic Acid Derivatives With Anticancer Activitymentioning

confidence: 99%

Section: Cinnamic Acid Derivatives With Anticancer Activitymentioning

confidence: 99%

Section: Cinnamic Acid Derivatives With Anticancer Activitymentioning

confidence: 99%

“…Chemical structures of zinc and indium tetra cinnamic acid phthalocyanine (Pc) complexes covalently linked to amino-functionalized magnetic nanoparticles (AMNPs)[35].…”

mentioning

confidence: 99%

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Cinnamic Acid Derivatives and Their Biological Efficacy

Ruwizhi

Aderibigbe

2020

IJMS

279

134

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“…Absorption in the appropriate NIR region • High photothermal conversion efficiency (L929 cell line-fibroblasts) (Z. Wang et al, 2019) Poly(ethylene glycol) methyl ether-block-poly(lactide-coglycolide) (PLGA-b-PEG) • The same photochemical properties as free ZnPc • Increased solubility in organic solvents • Efficient drug encapsulation • Increased phototoxicity (A549 cell line-lung cancer) Increased triplet quantum yields • Increased phototoxic effect • Increase in drug concentration in cells (MCF-7 cell line-breast cancer)(Matlou, Oluwole, & Nyokong, 2019) …”

mentioning

confidence: 99%

Nanocarriers in photodynamic therapy—in vitro and in vivo studies

Sztandera

Gorzkiewicz

Klajnert‐Maculewicz

2019

WIREs Nanomed Nanobiotechnol

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Photodynamic therapy (PDT) is a minimally invasive technique which has proven to be successful in the treatment of several types of tumors. This relatively simple method exploits three inseparable elements: phototoxic compound (photosensitizer [PS]), light source, and oxygen. Upon irradiation by light with specified wavelength, PS generates reactive oxygen species, which starts the cascade of reactions leading to cell death. The positive therapeutic outcome of PDT may be limited due to several aspects, including low water solubility of PSs, hampering their effective administration and blood circulation, as well as low tumor specificity, inefficient cellular uptake and activation energies requiring prolonged illumination times. One of the promising approaches to overcome these obstacles involves the use of carrier systems modulating pharmacokinetics and pharmacodynamics of the PSs. In the present review, we summarized current in vitro and in vivo studies regarding the use of nanoparticles as potential delivery devices for PSs to enhance their cellular uptake and cytotoxic properties, and thus—the therapeutic outcome of PDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Overview of Medical and Biological Applications of Indium(III) Complexes

Ajiboye,

Amao,

Adeyemi

et al. 2024

Chemistry Africa

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Indium(III) complexes are versatile species that emit Auger electrons which made them a choice for a wide range of biological and medical applications. The properties of these complexes depend on the primary ligand that was used for their syntheses. Herein, methods of synthesizing xanthates, dithiocarbamate, phthalocyanine, thiosemicarbazone and naphthalocyanine complexes of indium(III) are discussed. Also, the methods for synthesizing indium(III) complexes having other ligands are highlighted. Furthermore, antibacterial, antifungal and antiviral potential of the indium(III) complexes are comprehensively discussed. Other biological applications of the complexes such as anticancer, bioimaging, radiopharmaceutical, photodynamic chemotherapy, antioxidants, and optical limiting applications of these indium(III) complexes are comprehensively reviewed. In addition, toxicity of indium(III) complexes towards biological samples are examined because these must be considered in evaluating the safety and efficacy of indium(III) complexes for these numerous applications. Overall, indium(III) complexes are reported to have displayed a good performance in all these biological and medical applications. The future perspectives on the applications of indium(III) complexes are therefore suggested.

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Evaluation of the photosensitizing properties of zinc and indium tetra cinnamic acid phthalocyanines linked to magnetic nanoparticles on human breast adenocarcinoma cells

Cited by 13 publications

References 36 publications

Cinnamic Acid Derivatives and Their Biological Efficacy

Cinnamic Acid Derivatives and Their Biological Efficacy

Nanocarriers in photodynamic therapy—in vitro and in vivo studies

Overview of Medical and Biological Applications of Indium(III) Complexes

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