Evaluation of the Photostability and Photodynamic Efficacy of Rose Bengal Loaded in Multivesicular Liposomes

Fadel, Maha; Kassab, Kawser

doi:10.4314/tjpr.v10i3.5

Cited by 18 publications

(7 citation statements)

References 17 publications

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“…In this sense, it is not supposed to observe a scattering of light. Secondly, some studies demonstrated that xanthenes incorporated into lipid vesicles presented less photobleaching rates than in aqueous media .…”

Section: Resultsmentioning

confidence: 99%

Xanthene Dyes and Green LED for the Inactivation of Foodborne Pathogens in Planktonic and Biofilm States

Silva

Santos

Trevisan

et al. 2019

Photochem & Photobiology

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This study evaluated the rose bengal‐ and erythrosine‐mediated photoinactivation against Salmonella Typhimurium and Staphylococcus aureus planktonic and sessile cells using green LED as a light source. The free‐living or 2‐day‐old biofilm cells were treated with different concentrations of the photosensitizing agents and subjected to irradiation. Only 5 min photosensitization with rose bengal at 25 nmol L−1 and 75 μmol L−1 completely eliminated S. aureus and S. Typhimurium planktonic cells, respectively. Erythrosine at 500 nmol L−1 and 5 min of light exposure also reduced S. aureus planktonic cells to undetectable levels. Eradication of S. aureus biofilms was achieved when 500 μmol L−1 of erythrosine or 250 μmol L−1 of rose bengal was combined with 30 min of irradiation. Scanning electron microscopy allowed the observation of morphological changes in planktonic cells and disruption of the biofilm architecture after photodynamic treatment. The overall data demonstrate that rose bengal and erythrosine activated by green LED may be a targeted strategy for controlling foodborne pathogens in both planktonic and sessile states.

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Section: Resultsmentioning

confidence: 99%

Xanthene Dyes and Green LED for the Inactivation of Foodborne Pathogens in Planktonic and Biofilm States

Silva

Santos

Trevisan

et al. 2019

Photochem & Photobiology

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“…To improve RB uptake by cancer cells, RB was loaded into multivesicular and in light-triggered liposomes containing gold nanoparticles, and it was tested in vitro. 46,47 Results showed good intracellular RB uptake and a consequent increase in cell death rate in the first case, and good cell-killing efficacy of RB combined with gold in the second case. Gold has also been used in the form of nanorods and combined with photo-activated RB to generate ROS for killing oral cancer cells through the integrated effect of PDT and photo-thermal therapy offers advantages such as high effectiveness and specificity to oral cells both in vitro and in vivo in a hamster tumor model.…”

Section: Photodynamic Therapymentioning

confidence: 97%

Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review

Vanerio

Stijnen

Mol³

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

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“…Photostabilization of the drug substances by entrapment into liposomes is an effective method to improve their photostability. Examples of stabilization of the photosensitive drugs in liposomal formulations include riboflavin [163][164][165][166][167], doxorubicin [168], vitamin A palmitate [169], fluoroquinolones [170,171], rose Bengal [172], amlodipine [173], tretinoin [174], 2,7-dichlorodihydrofluorescein [175], opalmitoyl amylopectin [176], and zinc phthalocyanine and chloroaluminium phthalocyanine [177]. The entrapment efficiency of the liposomes facilitates the enhancement of the photostability of the drugs [164,165,174,178].…”

Section: Liposome Formationmentioning

confidence: 99%

Photostability and Photostabilization of Drugs and Drug Products

Ahmad

Ahmed

Anwar

et al. 2016

International Journal of Photoenergy

125

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Photostability studies of drugs and drug products are an integral part of the product development process in the pharmaceutical industry. These studies are carried out to ensure quality, efficacy, and safety of the formulated products during manufacture, storage, and use. This review deals with the concept of photostability and related aspects and the literature available in the field. It highlights the role of the photochemistry in the photostability studies, describes the functional groups important for the photoreactivity of drugs, explains photophysical processes, and deals with the kinetics of photochemical reactions. The various modes of photodegradation of drugs with examples of selected compounds are presented. The biological consequences of the effect of light on the drug degradation are described. The photostability testing of drugs and drug products and the requirements under ICH guideline are discussed. Some information on the packaging requirements for the formulated products is provided. The various methods used for the photostabilization of solid and liquid dosage forms are also discussed.

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Evaluation of the Photostability and Photodynamic Efficacy of Rose Bengal Loaded in Multivesicular Liposomes

Cited by 18 publications

References 17 publications

Xanthene Dyes and Green LED for the Inactivation of Foodborne Pathogens in Planktonic and Biofilm States

Xanthene Dyes and Green LED for the Inactivation of Foodborne Pathogens in Planktonic and Biofilm States

Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review

Photostability and Photostabilization of Drugs and Drug Products

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