Evaluation of the Phytochemistry–Therapeutic Activity Relationship for Grape Seeds Oil

Abstract

Seeds’ abundant biologically active compounds make them a suitable primary platform for the production of natural extracts, innovative foods, medicines, and cosmetics. High levels of industrial and agricultural residues and byproducts are generated during the processing of grapes, although some parts can also be repurposed. This paper examines the phytochemical composition, manufacturing processes, and health-improving attributes of many varieties of grape oil derived using various extraction methods. Since the results are influenced by a range of factors, they are expressed differently among studies, and the researchers employ a variety of measuring units, making it difficult to convey the results. The primary topics covered in most papers are grape seed oil’s lipophilic fatty acids, tocopherols, and phytosterols. In addition, new methods for extracting grape seed oil should therefore be designed; these methods must be affordable, energy-efficient, and environmentally friendly in order to increase the oil’s quality by extracting bioactive components and thereby increasing its biological activity in order to become part of the overall management of multiple diseases.

Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays

“…[ 55 ]. However, the thick-skinned red grapes known as Cabernet Sauvignon have seed oil with the highest polyphenol content [ 56 ].…”

Waste By-Product of Grape Seed Oil Production: Chemical Characterization for Use as a Food and Feed Supplement

“…Only a few quantities of these biomasses are used as compost for fertilization [ 8 , 9 ], as animal feed [ 7 , 10 , 11 ], or for the generation of other products [ 12 , 13 ]. Among these, the seeds have greater application importance, since grapeseed oil, which is appreciated in both the cosmetic and food sectors, is extracted from them [ 14 , 15 ]. In terms of composition, grape seeds represent a particularly complex waste material: they contain some valuable substances, mainly phenolic compounds (i.e., flavonoids), and vegetable oil, along with natural fibers, proteins, carbohydrates, and other micro-components [ 14 , 16 , 17 ].…”

“…Among these, the seeds have greater application importance, since grapeseed oil, which is appreciated in both the cosmetic and food sectors, is extracted from them [ 14 , 15 ]. In terms of composition, grape seeds represent a particularly complex waste material: they contain some valuable substances, mainly phenolic compounds (i.e., flavonoids), and vegetable oil, along with natural fibers, proteins, carbohydrates, and other micro-components [ 14 , 16 , 17 ]. Flavonoids, which are isolated unsaponifiable chemicals, play an important role in the inhibition of carcinogenesis, mutagenesis, and cardiovascular diseases and exhibit activities against peptic ulcers and several dermal disorders, such as acne and dermatitis [ 14 , 18 , 19 , 20 , 21 ].…”

“…In terms of composition, grape seeds represent a particularly complex waste material: they contain some valuable substances, mainly phenolic compounds (i.e., flavonoids), and vegetable oil, along with natural fibers, proteins, carbohydrates, and other micro-components [ 14 , 16 , 17 ]. Flavonoids, which are isolated unsaponifiable chemicals, play an important role in the inhibition of carcinogenesis, mutagenesis, and cardiovascular diseases and exhibit activities against peptic ulcers and several dermal disorders, such as acne and dermatitis [ 14 , 18 , 19 , 20 , 21 ]. The chemo-preventive and anti-cancer efficacy of grape seeds has led to the diffusion of health and dietary supplements in the form of capsules or tablets [ 21 ].…”

Unveiling the Pharmacological and Nanotechnological Facets of Daidzein: Present State-of-the-Art and Future Perspectives

“…The severe adverse effects of allopathic treatments on individual health have encouraged the emergence of natural remedies as potential therapeutics for acute and chronic disorders. The thousands of medicinal plants are utilized around the planet, which is attributed to their contribution towards potent therapeutic agents with numerous potential therapeutic effects, without producing serious side effects and, therefore, herbal medicines, by implicating plant-based compounds, have been accepted as being useful a remedy for numerous diseases [ 3 , 4 , 5 ].…”