Evaluation of the pre-treatment effect of Centella asiatica medicinal plants on long-term potentiation (LTP) in rat model of Alzheimer's disease

Doulah, Abdolhassan; Mahmoodi, Gelavij; Borujeni, Mahdi Pourmahdi

doi:10.1016/j.neulet.2020.135026

Cited by 9 publications

(7 citation statements)

References 28 publications

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“…In this study, we found that the MAPK pathway and neurotrophin signaling pathway were involved in the biological regulation of HDAC1 and HDAC8 with AD. All these pathways played a prominent role in AD pathology [ [36] , [37] , [38] , [39] , [40] ]. Our study provided a new therapy discovery on the impact of HDAC1 and HDAC8 involved in the neuropathology and genesis of AD and provided a supportive proof how HDAC8 participated in AD disease progression.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis identifies the role of Class I histone deacetylase in Alzheimer’s disease

Geng,

Zhao,

Chen

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Transcriptome analysis identifies the role of Class I histone deacetylase in Alzheimer’s disease

Geng,

Zhao,

Chen

et al. 2023

Heliyon

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“…PDK1, Akt, and GSK‐3β (Wu et al, 2020). Long‐term potentiation (LTP) (6 weeks) using C. asiatica extract (100 mg kg −1 ) before induction of The nucleus basalis of Meynert (NBM) lesion and Alzheimer's showed neuroprotection and enhanced memory in a rat model of Alzheimer's disease (Doulah, Mahmoodi, & Borujeni, 2020).…”

Section: Pharmacologymentioning

confidence: 99%

Ethnobotany, phytochemistry, pharmacology, and toxicity of Centella asiatica (L.) Urban: A comprehensive review

Biswas

Mandal

Saha

et al. 2021

Phytotherapy Research

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The medicinal plant C. asiatica (L.) Urban, belongs to the family Apiaceae, commonly known as "Pennywort." It is a perennial herb, normally grows in temperate and tropical wetlands. It consists of slender stems; creeping stolons; petiolate, stalked, and rounded leaves with palmately netted veins; pinkish, bisexual flowers and hairy, vertical, rhizomatous rootstock (S. Singh, Gautam, Sharma, & Batra, 2010).It is a slightly aromatic, herbaceous, stoloniferous, prostrate creeper of 12-15 cm in average height. Stem is rounded, glabrous, striated with rooting nodes. Leaves are 2-6 cm Â 1.5-5 cm in size, orbicularrenniform, glabrous, long petiolate with crenate margin, and sheathing leaf bases. Pinkish white to purple flowers are arranged in facicled umbels. Oblong shaped fruits are approximately 2 inches long with thickened pericarps and having seeds with the laterally compressed pendulous embryo (Prasad et al., 2014; S. Singh et al.). Habit and some morphological features of C. asiatica are presented in Figure 1. Taxonomic hierarchy of C. asiatica (L.

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“…Several neurological centers, including the amygdala, thalamus and hippocampus, parietal projections, and entorhinal cortex, influence memory and realizing, of which the hippocampus plays a significant role (4). The hippocampus is a segment of the temporal memory lobe implicated in the pathology of AD (5), whilst its synaptic communication is related to the formation of long-term potentiation (LTP). As a synaptic plasticity model, LTP incorporates neurobiological elements that sustain the hippocampal memory process (6).…”

Section: Introductionmentioning

confidence: 99%

“…An electrophysiological phenomenon is made at the synapse site after high-frequency electrical stimulation (tetanus) of the presynaptic neurons. Indeed, incitement of tetanus causes an abrupt and persistent increment in the postsynaptic reaction (hours to days) (5).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Sub-chronic Administration of Brewed Coffee on Long-term Potentiation in a Rat Model of Alzheimer's Disease

et al. 2022

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Background: Alzheimer's disease (AD) is a neurodegenerative illness that causes memory loss and cognitive impairment. For neurodegenerative illnesses, the therapeutic properties and healthy advantages of brewed coffee (BC) intake have been widely explored. Objectives: This research aimed to look into the findings of sub-chronic BC administration on long-term potentiation (LTP) as a model of synaptic plasticity that supports memory function in the hippocampus in rat models of AD. Methods: In this study, 32 male Wistar rats were utilized as test subjects. The animals were randomly divided into four groups with eight rats in each group as follows: (1) Sham (animals that received normal saline (NS)), (2) streptozotocin (STZ), (3) BC, and (4) BC-STZ. Animals were treated for three weeks. Results: The amplitude of excitatory postsynaptic potentials (EPSPs) in the BC + STZ (164.23 ± 11.33%; n = 8) group significantly increased compared to the STZ group at 0.25 h after HFS (P = 0.0330). Also, it significantly increased in the BC + STZ group at 0.5, 0.75, 1, 1.25, 1.5, 1.75, and 2 h (P = 0.4481, P = 0.4609, P = 0.1239, P = 0.0017, P = 0.0413, P = 0.0851, P = 0.1323) after HFS. Moreover, the slope of EPSPs in the BC-STZ group showed an overall improvement compared to the STZ group at 0.25, 0.5, 0.75, 1, 1.25, 1.5, 1.75, and 2 h (P = 0.1511, P = 0.0004, P = 0.0394, P = 0.0038, P = 0.0002, P = 0.0059, P = 0.0245, and P = 0.4126, respectively) after HFS during LTP recording time. Conclusions: In conclusion, the present study found that BC consumption improved synaptic plasticity and memory in rat models of AD induced by STZ. However, more studies are needed to elucidate BC's neuroprotective mechanisms.

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Evaluation of the pre-treatment effect of Centella asiatica medicinal plants on long-term potentiation (LTP) in rat model of Alzheimer's disease

Cited by 9 publications

References 28 publications

Transcriptome analysis identifies the role of Class I histone deacetylase in Alzheimer’s disease

Transcriptome analysis identifies the role of Class I histone deacetylase in Alzheimer’s disease

Ethnobotany, phytochemistry, pharmacology, and toxicity of Centella asiatica (L.) Urban: A comprehensive review

The Effect of Sub-chronic Administration of Brewed Coffee on Long-term Potentiation in a Rat Model of Alzheimer's Disease

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