Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome

Tieppo, Juliana; Vercelino, Rafael; Dias, Alexandre Simões; Vaz, Marlene; Silveira, Themis Reverbel da; Marroni, Cláudio Augusto; Marroni, Norma Possa; Henriques, João Antônio Pêgas; Picada, Jaqueline Nascimento

doi:10.1016/j.fct.2006.12.020

Cited by 60 publications

(56 citation statements)

References 44 publications

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“…In cirrhotic animals, there is a considerable increase in liver lipoperoxidation due to the formation of ROS, which has already been shown in hepatic tissue and eritrocytes by other studies (28,30) . The increased oxidative stress in the BDL model can be explained by endotoxemia and increased biliary acids, which can lead to an imbalance in the mitochondrial electron transport chain and can subsequently favor increased production of ROS (20,31) .…”

Section: Discussionsupporting

confidence: 68%

Cirrhosis Induces Apoptosis in Renal Tissue Through Intracellular Oxidative Stress

Silveira

Viau

Colares

et al. 2015

Arq. Gastroenterol.

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-Background -Renal failure is a frequent and serious complication in patients with decompensated cirrhosis. ObjectiveWe aimed to evaluate the renal oxidative stress, cell damage and impaired cell function in animal model of cirrhosis. Methods -Secondary biliary cirrhosis was induced in rats by ligation of the common bile duct. We measured TBARS, ROS and mitochondrial membrane potential in kidney as markers of oxidative stress, and activities of the antioxidant enzymes. Relative cell viability was determined by trypan blue dye-exclusion assay. Annexin V-PE was used with a vital dye, 7-AAD, to distinguish apoptotic from necrotic cells and comet assay was used for determined DNA integrity in single cells. Results -In bile duct ligation animals there was significant increase in the kidney lipoperoxidation and an increase of the level of intracellular ROS. There was too an increase in the activity of all antioxidant enzymes evaluated in the kidney. The percentage viability was above 90% in the control group and in bile duct ligation was 64.66% and the dominant cell death type was apoptosis. DNA damage was observed in the bile duct ligation.There was a decreased in the mitochondrial membrane potential from 71.40% ± 6.35% to 34.48% ± 11.40% in bile duct ligation. Conclusion -These results indicate that intracellular increase of ROS cause damage in the DNA and apoptosis getting worse the renal function in cirrhosis. HEADINGS -Liver cirrhosis. Renal insufficiency. Oxidative stress. Flow cytometry. Reactive oxygen species.

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Section: Discussionsupporting

confidence: 68%

Cirrhosis Induces Apoptosis in Renal Tissue Through Intracellular Oxidative Stress

Silveira

Viau

Colares

et al. 2015

Arq. Gastroenterol.

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“…In the presence of liver cirrhosis, there is an increase in lipid peroxidation due to the formation of reactive oxygen species and lipid peroxidation. Some authors report that these phenomena determine the changes in the structures and cell membranes by two mechanisms, covalent binding to macromolecules and cell action on lipids, and that these two mechanisms are the result of the metabolism of CCl 4 by cytochrome P-450, which produces two radicals which are highly toxic and CCl 3 CCl3O 2 •• (28) Additionally, reactive oxygen species (ROS) are involved in the BDL model.…”

Section: Discussionmentioning

confidence: 99%

Lung and Liver Changes Due to the Induction of Cirrhosis in Two Experimental Models

Ferrari

Tieppo

Rosa

et al. 2013

Arq. Gastroenterol.

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-Context -To evaluate lung and liver changes in two experimental models using intraperitoneal carbon tetrachloride (CCl 4 ) and bile duct ligation (BDL). Methods -Twenty-four male Wistar rats were divided into a control group (CO) and an experimental group (EX). We evaluated the liver transaminases (AST, ALT, AP), arterial blood gases (PaO 2 , PCO 2 and SpO 2 ) and lipid peroxidation by TBARS (substances that react to thiobarbituric acid) and chemiluminescence. We also evaluated the antioxidant enzyme superoxide dismutase (SOD) and histology of lung tissue and liver. Results -There were significant differences in AST, ALT, ALP and PaO 2 between CO group and EX group (P<0.05). The levels of TBARS, chemiluminescence and activity of enzyme superoxide dismutase were increased to different degrees in the CCl 4 groups: CO and in the BDL -EX (P<0.05, respectively). In the lung histology, an increase in the wall thickness of the pulmonary artery and a diameter reduction in the CCl 4 animal model were observed: comparing CO group with EX group, we observed a reduction in thickness and an increase in the diameter of the artery wall lung. Conclusion -Both experimental models have caused liver damage and alterations in the artery wall that are associated with major changes in pulmonary gas exchange.

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“…Quercetin occurs in glycosylated form in French beans, broccoli, apples and especially in onions [16] . Quercetin has been reported to increase the genomic stability in rats and enhance the antioxidative defense system by up regulating antioxidant enzymes [17] . Quercetin intake shows decreased incidence of cardiovascular and neoplastic diseases [18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

Padma

Lalitha

Shirony³

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome

Cited by 60 publications

References 44 publications

Cirrhosis Induces Apoptosis in Renal Tissue Through Intracellular Oxidative Stress

Cirrhosis Induces Apoptosis in Renal Tissue Through Intracellular Oxidative Stress

Lung and Liver Changes Due to the Induction of Cirrhosis in Two Experimental Models

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

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