Evaluation of the Quality of Different Brands of Ascorbic Acid in Freetown, Sierra Leone

Lahai, Michael; Conteh, Eugene B; Mansaray, Aminata Frederica; Amara, Joseph; Bawoh, Mohamed; Komeh, James P.; Tejan-Kella, Alphan; Sesay, Mohamed; Johnson, Wiltshire C. N.

doi:10.22159/ijpps.2021v13i9.41230

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Tablets can pass the friability test if the percentage of weight loss is within the range of 0.5%-1% of tablet weight. The percent friability can be determined using the following equation [11]: 2Where I represents initial weight and F denotes weight after friability.…”

Section: Friability Testmentioning

confidence: 99%

Quality Evaluation of Brands of Propranolol HCL Tablets Available on Iraqi Market

et al. 2022

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Objective: The purpose of this study is to evaluate the quality control of marketed tablets containing propranolol hydrochloride available on the Iraqi market and manufactured by different companies. Methods: Different batches of propranolol hydrochloride 40 mg tablets were assessed using quality control tests. Weight variation, diameter, thickness, friability, disintegration time and dissolution study were carried out in this study. Results: Based on the data obtained in this study, all brands of PPL available on the Iraqi market showed weight variation within the acceptable limit of USP. Marketed products of Becardin and Propranolol lie within the acceptable limit of hardness and Inderal was observed to be slightly higher than the normal upper range of USP. Diameter and thickness for all brands were almost the same, except the diameter of Becardin was slightly higher and friability was zero for all brands. All brands demonstrated a time of disintegration of fewer than 30 min. The tested marketed propranolol products; Inderal, Procard, Becardin and Propranolol showed cumulative drug release of 90.08%, 94.46%, 92.4% and 79.51%, respectively at the end of the first 20 min. This variation in the release profile of marketed tablets of Propranolol HCl might be attributed to the excipients present in the marketed tablets where some of these excipients may behave as a disintegrant and enhance dissolution rate while others may act as dissolution retardants. Conclusion: All marketed tablets of Propranolol HCl employed in this study were produced within the standard criteria of tablet manufacturing. Evaluation of quality control of these selected tablets showed acceptable pharmaceutical properties that lie within the limits of USP.

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Section: Friability Testmentioning

confidence: 99%

Quality Evaluation of Brands of Propranolol HCL Tablets Available on Iraqi Market

et al. 2022

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“…The quality of medications and pharmaceutical items is crucial to maintaining human health and wellness [10,11]. Poor quality control procedures can have disastrous effects when dealing with consumable goods that people depend on.…”

Section: Introductionmentioning

confidence: 99%

Quality Control Assessment of Dutasteride and Silodosin in Capsules and Tablets Employing a Novel Developed HPLC Technique; Evaluation of Stabilities of Dutasteride and Silodosin in Accelerated Degradation

JAGADEESH,

KADIYALA,

VARMA DENDUKURI

et al. 2023

Int J App Pharm

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Objective: The combination of dutasteride (DTRE) plus silodosin (SLDN) is used for treating acute urine retention brought upon by benign prostatic hyperplasia in men. The contents of DTRE and SLDN in capsules and tablets must be monitored for quality. In this research, a quick, selective and robust stability indicating HPLC method has been developed for concurrent assay of DTRE and SLDN in capsules and tablets. Also, the stabilities of DTRE and SLDN under several types of applied stress were determined. Methods: Analysis performed using Xterra Symmetry type column C18 (“4.6 mm x 150 mm, 5 mm” dimensions) and mobile phase having 0.1N strength, 20% volume fraction of dipotassium hydrogen phosphate and 80% volume fraction of pure form acetonitrile; PDA analysis was made at 265 nm. Stabilities of DTRE and SLDN were determined under several types of applied stress, including thermal, basic, oxidative, photo, and acid. Results: The elution times for DTRE and SLDN were 2.003 min and 3.377 min, respectively. DTRE and SLDN linear ranges were 20–120 µg/mL and 1.25–7.5 µg/mL, respectively. Method is precise with 0.2498% (DTRE) and 0.0773% (SLDN) RSD values. Method is accurate with 98.913-101.049% (DTRE) and 100.023-100.162% (SLDN) recovery values. In degradation investigation, degradant’s peaks elution times are different from the elution times of DTRE and SLDN. Thus, proved specificity and stability indicating power of the method. DTRE and SLDN were found relatively stable in thermal and were found sensitive in oxidation. In overall, SLDN found more sensitive to applied stress, including thermal, basic, oxidative, photo, and acid compared to DTRE. Conclusion: Finally, this developed analytical approach was efficaciously applied to a commercial capsule and tablet formulations containing fixed dose of DTRE and SLDN, demonstrating its usefulness for quality control and degradation investigations on DTRE and SLDN.

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Evaluation of the Quality of Different Brands of Ascorbic Acid in Freetown, Sierra Leone

Cited by 2 publications

References 9 publications

Quality Evaluation of Brands of Propranolol HCL Tablets Available on Iraqi Market

Quality Evaluation of Brands of Propranolol HCL Tablets Available on Iraqi Market

Quality Control Assessment of Dutasteride and Silodosin in Capsules and Tablets Employing a Novel Developed HPLC Technique; Evaluation of Stabilities of Dutasteride and Silodosin in Accelerated Degradation

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