Evaluation of the relationship between dietary factors,CagA-positiveHelicobacter pyloriinfection, andRUNX3promoter hypermethylation in gastric cancer tissue

Zhang, Yanwei; Eom, Sang‐Yong; Yim, Dong‐Hyuk; Song, Young‐Jin; Yun, Hyo-Yung; Park, Joo-Seung; Youn, Sei-jin; Kim, Byung-Sik; Kim, Yong‐Dae; Kim, Heon

doi:10.3748/wjg.v19.i11.1778

Cited by 22 publications

(18 citation statements)

References 41 publications

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“…Similar, but inverse, effects occur when zinc is limited (39) . Dietary habits such as high consumption of salt, proteins or nitrite have also been linked to the pathogenicity of H. pylori (40) . Furthermore, conditions in the stomach environment, such as altered pH, could facilitate colonization of the bacteria.…”

Section: Discussionmentioning

confidence: 99%

Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas

et al. 2015

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The reported associations with gastric adenocarcinoma and seropositivity to different H. pylori antigens using multiplex serology have not been consistent across studies. We aimed to investigate the association between fifteen different multiplex serology antigens and the risk of gastric cardia (GCA) and gastric non-cardia (GNCA) adenocarcinomas in northeastern Iran, a population with high rates of gastric adenocarcinoma. We included 272 cases of gastric adenocarcinoma (142 GCA, 103 GNCA, and 27 unspecified) and 524 controls who were individually matched to cases for age, sex, and place of residence in a population-based case-control study. Seropositivity to H. pylori was assessed using both multiplex serology and H. pylori IgG ELISA. 95% of controls were seropositive to H. pylori. Of the 15 antibodies in the multiplex assay, 11 showed no significant association with gastric adenocarcinomas. CagA and VacA were associated with a significantly increased risk of all gastric adenocarcinoma and GNCA in multivariate models. Surprisingly, GroEL and NapA were significantly associated with a reduced risk of these tumors. Only CagA antigen was associated with significantly elevated risk of GCA. We found no associations between H. pylori seropositivity overall either by whole-cell ELISA test or multiplex serology, likely due to the high prevalence of seropositivity. Individual antigen testing showed that CagA positivity was associated with increased risk of both noncardia and cardia adenocarcinoma, which is similar to some other Asian populations, while two antigens were associated with lower risk of gastric cancer. This latter result was unexpected and should be re-tested in other populations.

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Section: Discussionmentioning

confidence: 99%

Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas

et al. 2015

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“…Several studies among different geographical populations have shown that there might be association between infection with H pylori and Gastric cancer development (Thomazini et al, 2006;Zhang et al, 2013). Thomazini and colleagues (2006), for instances, observed that 95% of Brazilian patients with Gastric cancer had infection with H. pylori.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, cagA gene of H pylori is revealed to be involved in pathogenesis of Gastric cancer (Graham and Yamaoka, 1998;Zhang et al, 2013). In addition, cagA and the vacuolating cytotoxin (vacA) genotypes are proposed to serve as predictors for progression of gastric lesions (Gonzalez et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Investigation of Association between oipA and iceA1/iceA2 Genotypes of Helicobacter pylori and Gastric Cancer in Iran

Aghdam¹,

Sardari²,

Safaralizadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: H pylori is the main causative agent of Gastric cancer and chronic gastritis. Genetic diversity of H. pylori has major contribution in its pathogenesis. We investigated the prevalence of oipA and iceA1/iceA2 positive strains of H. pylori among patients with gastric cancer and gastritis. Materials and Methods: Sampling performed by means of endoscopy from 86 patients. DNA was extracted from tissue samples using DNA extraction kit. PCR assay was performed and products were monitored by Agarose Gel Electrophoresis. Results: Urease Test and 16S rRNA PCR did not show significant differences in detection of H. pylori. The frequency of iceA1 allele in patients with gastric cancer was significantly higher than those with gastritis (p<0.05). However, there was no significant difference in prevalence of oipA and iceA2 genes among the two groups of patients (p>0.05). Conclusions: The iceA1 gene, but the oipA and iceA2 genes , is associated with H. pylori-induced gastric cancer. However, confirmatory studies must be performed in future.

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“…A body of evidence suggests that Runx3 may function as a tumor suppressor in various cancer types (22)(23)(24). Some studies have indicated that inactivation of Runx3 protein by various chemical modifications may contribute to tumor pathogenesis, initiation and progression in specific microenvironmental contexts.…”

Section: Discussionmentioning

confidence: 99%

Mislocalization of Runt-related transcription factor 3 results in airway inflammation and airway hyper-responsiveness in a murine asthma model

Zhou

Zhu

Bian

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The Runt-related transcription factor (RUNX) gene family consists of three members, RUNX1, -2 and -3, which heterodimerize with a common protein, core-binding factor β, and contain the highly conserved Runt-homology domain. RUNX1 and -2 have essential roles in hematopoiesis and osteogenesis. Runx3 protein regulates cell lineage decisions in neurogenesis and thymopoiesis. The aim of the present study was to determine the expression features of the Runx3 protein in a murine asthma model. In vivo, Runx3 protein and mRNA were found to be almost equivalently expressed in the murine lung tissue of the control, ovalbumin (OVA) and genistein groups; however, the nuclear Runx3 protein was abated in lung tissue in OVA-immunized and challenged mice. Following treatment with genistein, which is a flavonoid previously demonstrated to decrease airway inflammation in asthma, the allergic airway inflammation and airway hyper-responsiveness were attenuated and the Runx3 protein tended to augment in the nucleus. These results were further determined in vitro. These results indicated that the mislocalization of Runx3 protein is a molecular mechanism of allergic inflammation and airway hyper-responsiveness in a murine asthma model.

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Evaluation of the relationship between dietary factors,CagA-positiveHelicobacter pyloriinfection, andRUNX3promoter hypermethylation in gastric cancer tissue

Abstract: These results suggest that the CagA status of H. pylori infection may be a modifier of dietary effects on RUNX3 methylation in gastric cancer tissue.

Cited by 22 publications

References 41 publications

Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas

Multiplex H. pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas

Investigation of Association between oipA and iceA1/iceA2 Genotypes of Helicobacter pylori and Gastric Cancer in Iran

Mislocalization of Runt-related transcription factor 3 results in airway inflammation and airway hyper-responsiveness in a murine asthma model

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