Evaluation of the relationship of the molecular aggregation state of amphotericin B in medium to its genotoxic potential**This article was presented in part at the Pharmaceutical Congress of the Americas, Orlando, FL, 2001.

Egito, Lucila Carmem Monte; Medeiros, Sílvia Regina Batistuzzo de; Medeiros, Maria G.L.; Price, James C.; Egito, Eryvaldo Sócrates Tabosa do

doi:10.1002/jps.20038

Cited by 10 publications

(1 citation statement)

References 27 publications

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“…Based on the study of Egito et al (2007), the chemical (H2O2) utilized in this study was a control mutagen. This chemical, being naturally produced by the cells, is a common genotoxin or a form of reactive oxygen species (ROS) produced by oxidative physiologic stress of cells.…”

Section: Cytotoxic and Mutagenic Properties Of H2o2mentioning

confidence: 99%

Mitodepressive and Genotoxic Potential of Crude Body Wall and Cuvierian Tubule Extracts of Mani-mani (Pearsonothuria graeffei Semper) on Root Meristems of Onion (Allium cepa L.)

Torres,

Malaya

2021

MJST

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The need to discover novel natural products has resulted in several explorations in the marine environment. The biological compounds from aquatic resources can boost effort on drug development and may promote species conservation. In this study, the mitodepressive and genotoxic properties of the extracts obtained from Pearsonothuria graeffei – a widely distributed and poorly explored sea cucumber species – were evaluated using the Allium test. The sea cucumber body wall and cuvierian tubule crude methanol, ethyl acetate and n-hexane extracts were found to have potential genotoxic properties at concentrations of 500, 1,000 and 1,500 μg mL-1. A significant (p < 0.05) growth inhibition in both length and the number of roots was exhibited at higher concentrations (1,000 and 1,500 μg mL-1) of the crude extracts similar to the control mutagen. The 1,000 μg mL-1 of cuvierian tubule methanol extract resulted in higher general toxicity in terms of root length inhibition than the control mutagen. A significantly lower mitotic index was exhibited in the crude body wall methanol extract at 500 μg mL-1 concentration. Also, a higher percent chromosomal aberration (p < 0.05) was observed in onions treated with all concentrations of crude body wall ethyl acetate and n-hexane extracts, and 500 μg mL-1 of the crude cuvierian tubule methanol and n-hexane extracts. In conclusion, the crude extracts of P. graeffei have mitodepressive and genotoxic properties, which are potential sources of bioactive compounds necessary for the development of treatment for some serious human diseases like cancer.

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Section: Cytotoxic and Mutagenic Properties Of H2o2mentioning

confidence: 99%