Evaluation of the response to treatment of psoriasis vulgaris with reflectance confocal microscopy

Başaran, Yeliz Karakoca; Gürel, Mehmet Salih; Erdemir, Aslı Turgut; Turan, Enver; Yurt, Nurdan; Bağcı, Işın Sinem

doi:10.1111/srt.12150

Cited by 28 publications

(33 citation statements)

References 16 publications

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“…As for visual representation, HFUS captures images in the vertical plane while RCM captures images in the horizontal plane [15]. In contrast, OCT has the advantage of capturing images in both the horizontal and vertical planes.…”

Section: Discussionmentioning

confidence: 99%

Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography

Aldahan

Chen

Fertig

et al. 2016

Skin Appendage Disord

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Background: Nail psoriasis is a painful and disfiguring nail disease that often leads to invasive biopsies. Dermoscopy of the hyponychium can be useful in the diagnosis showing twisted coiled vessels. Structural features of nail psoriasis have been described with optical coherence tomography (OCT). Objectives: To investigate vascular features of nail psoriasis using dynamic OCT. Methods: This was an observational, prospective, controlled study in which psoriasis patients with psoriatic nail changes and healthy control patients underwent OCT imaging of the distal nail plate and proximal nail fold. Vertical and horizontal OCT images were analyzed to describe structural and vascular features and to quantify blood flow at depth. Results: Sixteen psoriatic nails and 16 control nails were included. Psoriatic nails had significantly increased blood flow in the proximal nail fold at depths of 0.72 mm (p = 0.035) and 0.76 mm (p = 0.027). Nail thickness was significantly greater in psoriatic nails compared to control nails (p = 0.0016). Compared to control nails, psoriatic nails had dilated, disorganized blood vessels superficially in the proximal nail fold. Limitations: The main limitation of our study is the relatively small sample size. Conclusions: OCT can identify structural and vascular features specific to nail psoriasis.

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Section: Discussionmentioning

confidence: 99%

Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography

Aldahan

Chen

Fertig

et al. 2016

Skin Appendage Disord

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“…After reviewing all publications, an overview of general psoriatic RCM features was provided for diagnostic and monitoring purposes (Table ). Four therapeutic follow‐up studies monitored different therapeutics; phototherapy [ultraviolet B (UVB) and psoralen ultraviolet A], topical non‐steroidal anti‐inflammatory drugs, topical corticosteroids, Methotrexate, Acitretin and/or Calcipotriol and Adalimumab by RCM . RCM features showed a good correlation with clinical improvement and improvement of Psoriasis Area Severity Index (PASI) scores .…”

Section: Methodsmentioning

confidence: 99%

“…Four therapeutic follow‐up studies monitored different therapeutics; phototherapy [ultraviolet B (UVB) and psoralen ultraviolet A], topical non‐steroidal anti‐inflammatory drugs, topical corticosteroids, Methotrexate, Acitretin and/or Calcipotriol and Adalimumab by RCM . RCM features showed a good correlation with clinical improvement and improvement of Psoriasis Area Severity Index (PASI) scores . In addition, RCM was able to show subclinical psoriatic features (orthokeratosis with abnormal compact aspect, high number of dermal papillae (DP), vascularization in DP and drastic reduction in inflammation) and in non‐responders to UVB large clustered tortuous capillaries were shown .…”

Section: Methodsmentioning

confidence: 99%

“…RCM features showed a good correlation with clinical improvement and improvement of Psoriasis Area Severity Index (PASI) scores . In addition, RCM was able to show subclinical psoriatic features (orthokeratosis with abnormal compact aspect, high number of dermal papillae (DP), vascularization in DP and drastic reduction in inflammation) and in non‐responders to UVB large clustered tortuous capillaries were shown . Based on this literature (Appendix S1), a therapeutic follow‐up scheme was proposed (Table ).…”

Section: Methodsmentioning

confidence: 99%

“…The correlation between histopathology and RCM imaging has been studied extensively in this inflammatory disease . In addition, some therapeutic follow‐up studies of psoriasis have been published …”

Section: Introductionmentioning

confidence: 99%

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A four‐phase strategy for the implementation of reflectance confocal microscopy in dermatology

Hoogedoorn

Gerritsen

Wolberink

et al. 2016

Acad Dermatol Venereol

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Reflectance confocal microscopy as a useful diagnostic tool for monitoring of skin containing vascularized composite allograft rejection: A preliminary study on rats

Zor

Karagöz

Erdemir³

et al. 2015

Microsurgery

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Vascularized composite allografts can undergo immune-mediated rejection, and skin biopsies are needed for monitoring of the transplant. However it is an invasive method, and requires processing time and pathological assessment. The purpose of this study is to use a new noninvasive monitoring method of the reflectance confocal microscopy (RCM) to determine severity of the allograft rejection on rats. Five groin flap allotransplantation were performed between 10 male Sprague-Dawley rats. Immunosuppressive therapy with cyclosporine A was given to the recipients during 10 days after surgery and was ended at the 10th postoperative days to allow acute transplant rejection. Following cessation of CsA, concomitant RCM evaluation and skin biopsy was performed every other day from each animal until total rejection of the allograft. Complete rejection of the allograft took nearly about 10 days and 4 or 5 RCM evaluation and skin biopsy was performed from each rat during this period. A total of 17 specimens were evaluated. A scoring system was developed based on the RCM findings. Skin biopsies were evaluated according to the Banff 2007 working classification criteria. RCM evaluation revealed epidermal irregularity and collagen destruction, however mild perivascular inflammation and degeneration of the basal epidermal layer were observed in early and late rejection period respectively with histopathologic evaluation. High correlation was found between the RCM scores and histopathologic grading. The RCM may be the useful tool to reduce the need for skin biopsy for monitoring of the skin containing vascularized composite allograft.

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Evaluation of the response to treatment of psoriasis vulgaris with reflectance confocal microscopy

Cited by 28 publications

References 16 publications

Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography

Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography

A four‐phase strategy for the implementation of reflectance confocal microscopy in dermatology

Reflectance confocal microscopy as a useful diagnostic tool for monitoring of skin containing vascularized composite allograft rejection: A preliminary study on rats

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