Evaluation of the sedative, analgesic, clinicophysiological and haematological effects of intravenous detomidine, detomidine‐butorphanol, romifidine and romifidine‐butorphanol in standing donkeys

Abstract

The aim of this investigation was to determine and evaluate the sedative, analgesic, clinicophysiological and haematological effects of intravenous (i.v.) injection of detomidine, detomidine-butorphanol, romifidine and romifidine-butorphanol. Six standing donkeys were used. Each donkey received 4 i.v. treatments and the order of treatment was randomised with a one-week interval between each treatment. We found that i.v. injection of a combination of detomidine-butorphanol or romifidine-butorphanol produced potent neuroleptanalgesic effects thus providing better, safe and effective sedation with complete analgesia in standing donkeys compared with injection of detomidine or romifidine alone. The changes and reduction in pulse rate were within acceptable limits. The changes in clinicophysiological, haematological and biochemical values were mild and transient in these clinically healthy donkeys.

Comparative Efficacy of Xylazine, Detomidine and Romifidine as Epidural Anesthetics in Egyptian Goat (Capra Hircus)

“…The changes in BUN levels were non-significant [9] except at 75 min in first group was significantly increased which may be referred to increase amino acid degradation [12], then its level return to physiological limits. Decreases in the BUN levels were observed with the administration of detomidine and romifidine [31]. The observed decrease may be as a result of increase in renal function in response to the elimination of these drugs then returned to the physiological limits.…”

“…The significant decrease of ALT in the goats received XYL might be attributed to the stress produced in first group because of systemic absorption of xylazine and changes in body temperature [32]. The significant increase of AST in XYL and DET received goats may be due to the possible hypotension and hypoxemia that may cause the release of these enzymes from the heart muscles or liver [31].…”

Analgesic Effect of Butorphanol during Castration in Donkeys under Total Intravenous Anaesthesia

“…The association of detomidine and butorphanol in equids is demonstrated to be a valuable and safe tool for pharmacological restraint, allowing one to reduce the adverse effects mediated by the use of a high amount of alpha-2 agonists [ 1 , 13 , 30 , 63 , 64 , 65 ]. In the literature, the dosage of detomidine and butorphanol ranges from 5–40 µg/kg and 25–50 µg/kg, respectively.…”

Effect on Clinico-Physiological Parameters after Administration of Buprenorphine-Propofol Anaesthesia in Atropinized Goats

“…The fall in rectal temperature may be a sequel to thermoregulatory depression and decreased metabolic rate due to propofol which was further potentiated by buprenorphine. As it also exerts depressive effect on thermoregulatory centres in hypothalamus, the reduction in rectal temperature is considered secondary to CNS depression and reduction in the muscular activity (Kammar et al, 2014). min.…”