Evaluation of the sensitivity of a new fully implantable telemetry device and the importance of simultaneously measuring cardiac output and left ventricular pressure

Translational assessment of cardiac contractility by echocardiography in the telemetered rat

“…In the present study, milrinone, a PDE III inhibitor, significantly increased dP/dt max with simultaneous increases in heart rate. The results were consistent with the literature for rats in both conscious (4) or anesthetized (14) preparations, as well as for conscious dogs (3,15).…”

“…Cardiac contractility indices such as LV dP/dt max are measured commonly in preclinical studies using conscious telemetered animals (1)(2)(3)(4)(5). However, LV dP/dt max measurements in the clinic are impractical due to its invasive nature, where noninvasive methods such as A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 3 echocardiography are routinely used to assess cardiac function in patients (6)(7)(8)(9). The translation of preclinical contractility indices to clinical meaning or functional consequence has not been described.…”