Evaluation of the sensitivity, specificity, positive and negative predictive values of preoperative magnetic resonance imaging for staging endometrial cancer

Myometrial invasion in endometrial cancer: diagnostic performance of diffusion-weighted MR imaging at 1.5-T

“…In particular, this study confirms that a lack of deep myometrial invasion on preoperative MR imaging allows it to be ruled out reliably [14]. Such knowledge has critical importance in selecting the most appropriate surgical treatment in these patients, that is, whether to perform pelvic and/or para-aortic lymphadenectomy.…”

“…For each sequence used, the exact localisation of the deepest myometrial invasion was identified (referring to: anterior wall of the uterus; posterior wall; left-side wall; right-side wall and fundus), and in that site the extension of the tumour into the myometrium and the myometrial thickness was measured. Myometrial invasion was calculated as the ratio of the two measurements and was classified into two categories-no or superficial and deep-in agreement with previous reports [14,23]. No or superficial myometrial invasion was defined as tumour limited to the endometrium or invading less than one half of the thickness of the myometrium; deep invasion was defined as tumour invasion reaching one half or more of the myometrial thickness [1].…”

“…Among them, magnetic resonance (MR) imaging has proved to be the most accurate [8,9]. According to previous reports [10][11][12][13][14], MR T2-weighted and dynamic contrast-enhanced T1-weighted images are considered most useful for assessing the extent of tumour spread, although their evaluation of the depth of myometrial invasion may be affected by several pitfalls [12][13][14].…”

Accuracy of MR Imaging in endometrial cancer: our experience

“…4 They concluded that DWI offered potential advantages over Dynamic Contrast enhanced MRI as it did not involve use of intravenous contrast which would be contraindicated in patients with renal impairment. 5 McComiskey MH et al found sensitivity and specificity of preoperative MRI for detection of outer half myometrial invasion to be 73% and 83% respectively and concluded that addition of MRI to preoperative assessment led to improved preoperative assessment, triage, and treatment. 6 Kim et al compared TVUS, CT and MRI for detection of deep myometrial invasion and found MRI to be significantly superior to other imaging modalities.…”

Application of 1.5 T magnetic resonance imaging in endometrial cancer

“…Remarkably, we found a specificity as high as 93.08% for the detection of cervical involvement. Nevertheless, the sensitivity of MRI in detecting cervical spreading was 52.63%, slightly better than that reported by recent papers [13]. A number of factors may help explain false positive and false negative results.…”